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Cited by 287

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

A simple and fast secondary structure prediction method using hidden neural networks

Open access
Lin, Kuang, Simossis, Victor A., Taylor, Willam R., Heringa, Jaap·2005·Bioinformatics

Abstract

Motivation: In this paper, we present a secondary structure prediction method YASPIN that unlike the current state-of-the-art methods utilizes a single neural network for predicting the secondary structure elements in a 7-state local structure scheme and then optimizes the output using a hidden Markov model, which results in providing more information for the prediction. Results: YASPIN was compared with the current top-performing secondary structure prediction methods, such as PHDpsi, PROFsec, SSPro2, JNET and PSIPRED. The overall prediction accuracy on the independent EVA5 sequence set is comparable with that of the top performers, according to the Q3, SOV and Matthew's correlations accuracy measures. YASPIN shows the highest accuracy in terms of Q3 and SOV scores for strand prediction. Availability: YASPIN is available on-line at the Centre for Integrative Bioinformatics website (http://ibivu.cs.vu.nl/programs/yaspinwww/) at the Vrije University in Amsterdam and will soon be mirrored on the Mathematical Biology website (http://www.mathbio.nimr.mrc.ac.uk) at the NIMR in London. Contact: kxlin@nimr.mrc.ac.uk

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Metadata

Authors
Lin, K., Simossis, V. A., Taylor, W. R., & Heringa, J.
Venue
Bioinformatics
Published
2004-09-17
Volume
21
Issue
2
Pages
152-159
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2098464924
Cited by
287
References
30
FWCI
5.69
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A simple and fast secondary structure prediction method using hidden neural networks. https://app.cochat.ai/papers/10.1093/bioinformatics/bth487
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Lin, K., Simossis, V. A., Taylor, W. R., & Heringa, J. (2005). A simple and fast secondary structure prediction method using hidden neural networks. Bioinformatics. https://doi.org/10.1093/bioinformatics/bth487

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