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PilZ domain is part of the bacterial c-di-GMP binding protein
Abstract
Recent studies identified c-di-GMP as a universal bacterial secondary messenger regulating biofilm formation, motility, production of extracellular polysaccharide and multicellular behavior in diverse bacteria. However, except for cellulose synthase, no protein has been shown to bind c-di-GMP and the targets for c-di-GMP action remain unknown. Here we report identification of the PilZ (‘pills’) domain (Pfam domain PF07238) in the sequences of bacterial cellulose synthases, alginate biosynthesis protein Alg44, proteins of enterobacterial YcgR and firmicute YpfA families, and other proteins encoded in bacterial genomes and present evidence indicating that this domain is (part of) the long-sought c-di-GMP-binding protein. Association of the PilZ domain with a variety of other domains, including likely components of bacterial multidrug secretion system, could provide clues to multiple functions of the c-di-GMP in bacterial pathogenesis and cell development. Contact: galperin@ncbi.nlm.nih.gov Supplementary information:
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Cited by
Valentini, M., & Filloux, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.711507 · Cited by 668
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 486
A Molecular Description of Cellulose Biosynthesis
McNamara, J. T., Morgan, J. L. W., & Zimmer, J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033930 · Cited by 382
Structural basis of ligand binding by a c-di-GMP riboswitch
Smith, K. D., Lipchock, S. V., Ames, T. D., Wang, J., Breaker, R. R., & Strobel, S. A. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1702 · Cited by 284
Nobles, D. R., & Brown, R. M. (2008) · Cellulose · doi:10.1007/s10570-008-9217-5 · Cited by 61
Metadata
- Authors
- Amikam, D., & Galperin, M. Y.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-25
- Volume
- 22
- Issue
- 1
- Pages
- 3-6
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2145792008
- Cited by
- 514
- References
- 0
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amikam, D., & Galperin, M. Y. (2006). PilZ domain is part of the bacterial c-di-GMP binding protein. Bioinformatics. https://doi.org/10.1093/bioinformatics/bti739
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