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Exome-based analysis for RNA epigenome sequencing data

Open access
Meng, Jia, Cui, Xiaodong, Rao, Manjeet K., Chen, Yidong, Huang, Yufei·2013·Bioinformatics

Abstract

Motivation: Fragmented RNA immunoprecipitation combined with RNA sequencing enabled the unbiased study of RNA epigenome at a near single-base resolution; however, unique features of this new type of data call for novel computational techniques. Result: Through examining the connections of RNA epigenome sequencing data with two well-studied data types, ChIP-Seq and RNA-Seq, we unveiled the salient characteristics of this new data type. The computational strategies were discussed accordingly, and a novel data processing pipeline was proposed that combines several existing tools with a newly developed exome-based approach ‘exomePeak’ for detecting, representing and visualizing the post-transcriptional RNA modification sites on the transcriptome. Availability: The MATLAB package ‘exomePeak’ and additional details are available at http://compgenomics.utsa.edu/exomePeak/. Contact: yufei.huang@utsa.edu or jmeng@mit.edu Supplementary information: Supplementary data are available at Bioinformatics online.

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Metadata

Authors
Meng, J., Cui, X., Rao, M. K., Chen, Y., & Huang, Y.
Venue
Bioinformatics
Published
2013-04-14
Volume
29
Issue
12
Pages
1565-1567
ISSN
  • 1367-4803 (ISSN-L)
  • 1367-4811
OpenAlex
W2166153887
Cited by
193
References
4
FWCI
2.42
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Exome-based analysis for RNA epigenome sequencing data. https://app.cochat.ai/papers/10.1093/bioinformatics/btt171
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Meng, J., Cui, X., Rao, M. K., Chen, Y., & Huang, Y. (2013). Exome-based analysis for RNA epigenome sequencing data. Bioinformatics. https://doi.org/10.1093/bioinformatics/btt171

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