The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Formation and function of sperm tail structures in association with sperm motility defects†
Abstract
Male infertility is an increasing problem partly due to inherited genetic variations. Mutations in genes involved in formation of the sperm tail cause motility defects and thus male infertility. Therefore, it is crucial to understand the protein networks required for sperm differentiation. Sperm motility is produced through activation of the sperm flagellum, which core structure, the axoneme, resembles motile cilia. In addition to this, cytoskeletal axonemal structure sperm tail motility requires various accessory structures. These structures are important for the integrity of the long tail, sperm capacitation, and generation of energy during sperm passage to fertilize the oocyte. This review discusses the current knowledge of mechanisms required for formation of the sperm tail structures and their effect on fertility. The recent research based on animal models and genetic variants in relation to sperm tail formation and function provides insights into the events leading to fertile sperm production. Here we compile a view of proteins involved in sperm tail development and summarize the current knowledge of factors contributing to reduced sperm motility, asthenozoospermia, underline the mechanisms which require further research, and discuss related clinical aspects on human male infertility.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Miki, K., Qu, W., Goulding, E. H., Willis, W. D., Bunch, D. O., Strader, L. F., Perreault, S. D., Eddy, E. M., & O'Brien, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407708101 · Cited by 620
Qi, H., Moran, M. M., Navarro, B., Chong, J. A., Krapivinsky, G., Krapivinsky, L., Kirichok, Y., Ramsey, I. S., Quill, T. A., & Clapham, D. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610286104 · Cited by 523
Ben Khelifa, M., Coutton, C., Zouari, R., Karaouzène, T., Rendu, J., Bidart, M., Yassine, S., Pierre, V., Delaroche, J., Hennebicq, S., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.11.017 · Cited by 474
Targeted Disruption of the Akap4 Gene Causes Defects in Sperm Flagellum and Motility
Miki, K., Willis, W. D., Brown, P. R., Goulding, E. H., Fulcher, K. D., & Eddy, E. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0728 · Cited by 403
Roest, H. P., van Klaveren, J., de Wit, J., van Gurp, C. G., Koken, M. H. M., Vermey, M., van Roijen, J. H., Hoogerbrugge, J. W., Vreeburg, J. T. M., Baarends, W. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80154-3 · Cited by 396
Fibrous sheath of mammalian spermatozoa
Eddy, E. M., Toshimori, K., & O'Brien, D. A. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10320 · Cited by 383
Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use?
du Plessis, S., Agarwal, A., Mohanty, G., & van der Linde, M. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.135123 · Cited by 382
Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins
Omran, H., Kobayashi, D., Olbrich, H., Tsukahara, T., Loges, N. T., Hagiwara, H., Zhang, Q., Leblond, G., O’Toole, E., Hara, C., et al. (2008) · Nature · doi:10.1038/nature07471 · Cited by 370
Teratozoospermia: spotlight on the main genetic actors in the human
Coutton, C., Escoffier, J., Martinez, G., Arnoult, C., & Ray, P. F. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv020 · Cited by 352
The Control of Male Fertility by Spermatozoan Ion Channels
Lishko, P. V., Kirichok, Y., Ren, D., Navarro, B., Chung, J.-J., & Clapham, D. E. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153258 · Cited by 341
Cited by
In-cell structural insight into the stability of sperm microtubule doublet
(2023) · doi:10.1038/s41421-023-00606-3 · Cited by 45
The primary cilia are associated with the axon initial segment in neurons
Wang, H., Li, Y., Li, X., Sun, Z., Yu, F., Pashang, A., Kulasiri, D., Li, H. W., Chen, H., Hou, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202407405 · Cited by 13
van den Hoven, L., van Vrouwerff, N. J., Dijkstra, I. M., Weeteling, J., Brinkman, J. W., Eliveld, J., & Wetzels, A. M. M. (2025) · Andrology · doi:10.1111/andr.13684 · Cited by 4
Metadata
- Authors
- Lehti, M. S., & Sironen, A.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-08-30
- Volume
- 97
- Issue
- 4
- Pages
- 522-536
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2752455371
- Cited by
- 267
- References
- 120
- FWCI
- 14.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Formation and function of sperm tail structures in association with sperm motility defects†. https://app.cochat.ai/papers/10.1093/biolre/iox096
- The paper
- Lehti, M. S., & Sironen, A. (2017). Formation and function of sperm tail structures in association with sperm motility defects†. Biology of Reproduction. https://doi.org/10.1093/biolre/iox096
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
