The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Control of Male Fertility by Spermatozoan Ion Channels
Open accessAbstract
Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome reaction. CatSper, a pH-regulated, calcium-selective ion channel, and KSper (Slo3) are core regulators of sperm tail calcium entry and sperm hyperactivated motility. Many other channels had been proposed as regulating sperm activity without direct measurements. With the development of the sperm patch-clamp technique, CatSper and KSper have been confirmed as the primary spermatozoan ion channels. In addition, the voltage-gated proton channel Hv1 has been identified in human sperm tail, and the P2X2 ion channel has been identified in the midpiece of mouse sperm. Mutations and deletions in sperm-specific ion channels affect male fertility in both mice and humans without affecting other physiological functions. The uniqueness of sperm ion channels makes them ideal pharmaceutical targets for contraception. In this review we discuss how ion channels regulate sperm physiology.
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Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Self-citationNongenomic actions of steroid hormones
Lösel, R., & Wehling, M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1009 · Cited by 980
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Mechanisms of sperm chemotaxis
Kaupp, U. B., Kashikar, N. D., & Weyand, I. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100654 · Cited by 284 · cited 2×
“A more recent variation of this model proposes that cyclic nucleotides activate the hyperpolarization-activated and cyclic nucleotide– gated (HCN) channels, resulting in the depolarization and subsequent opening of Ca2+ channels (79, 152).”
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Cited by
Rheotaxis Guides Mammalian Sperm
Miki, K., & Clapham, D. E. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.007 · Cited by 444
Self-citationLifestyle and fertility: the influence of stress and quality of life on male fertility
Ilacqua, A., Izzo, G., Emerenziani, G. P., Baldari, C., & Aversa, A. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0436-9 · Cited by 313
Formation and function of sperm tail structures in association with sperm motility defects†
Lehti, M. S., & Sironen, A. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox096 · Cited by 267
EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner
Rehfeld, A., Egeberg, D. L., Almstrup, K., Petersen, J. H., Dissing, S., & Skakkebæk, N. E. (2018) · Endocrine Connections · doi:10.1530/ec-17-0156 · Cited by 58
Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells
Rehfeld, A., Dissing, S., & Skakkebæk, N. E. (2016) · Endocrinology · doi:10.1210/en.2016-1473 · Cited by 56
Metadata
- Authors
- Lishko, P. V., Kirichok, Y., Ren, D., Navarro, B., Chung, J.-J., & Clapham, D. E.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2012-03-17
- Volume
- 74
- Issue
- 1
- Pages
- 453-475
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2109279728
- Cited by
- 341
- References
- 4
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Lishko, P. V., Kirichok, Y., Ren, D., Navarro, B., Chung, J.-J., & Clapham, D. E. (2012). The Control of Male Fertility by Spermatozoan Ion Channels. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-020911-153258
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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