The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial
Open accessAbstract
Background In early postpartum haemorrhage (PPH), a low concentration of fibrinogen is associated with excessive subsequent bleeding and blood transfusion. We hypothesized that pre-emptive treatment with fibrinogen concentrate reduces the need for red blood cell (RBC) transfusion in patients with PPH.Methods In this investigator-initiated, multicentre, double-blinded, parallel randomized controlled trial, we assigned subjects with severe PPH to a single dose of fibrinogen concentrate or placebo (saline). A dose of 2 g or equivalent was given to all subjects independent of body weight and the fibrinogen concentration at inclusion. The primary outcome was RBC transfusion up to 6 weeks postpartum. Secondary outcomes were total blood loss, total amount of blood transfused, occurrence of rebleeding, haemoglobin <58 g litre(-1), RBC transfusion within 4 h, 24 h, and 7 days, and as a composite outcome of 'severe PPH', defined as a decrease in haemoglobin of >40 g litre(-1), transfusion of at least 4 units of RBCs, haemostatic intervention (angiographic embolization, surgical arterial ligation, or hysterectomy), or maternal death.Results Of the 249 randomized subjects, 123 of 124 in the fibrinogen group and 121 of 125 in the placebo group were included in the intention-to-treat analysis. At inclusion the subjects had severe PPH, with a mean blood loss of 1459 (sd 476) ml and a mean fibrinogen concentration of 4.5 (sd 1.2) g litre(-1). The intervention group received a mean dose of 26 mg kg(-1) fibrinogen concentrate, thereby significantly increasing fibrinogen concentration compared with placebo by 0.40 g litre(-1) (95% confidence interval, 0.15-0.65; P=0.002). Postpartum blood transfusion occurred in 25 (20%) of the fibrinogen group and 26 (22%) of the placebo group (relative risk, 0.95; 95% confidence interval, 0.58-1.54; P=0.88). We found no difference in any predefined secondary outcomes, per-protocol analyses, or adjusted analyses. No thromboembolic events were detected.Conclusions We found no evidence for the use of 2 g fibrinogen concentrate as pre-emptive treatment for severe PPH in patients with normofibrinogenaemia.Clinical trial registration ClinicalTrials.gov: http://clinicaltrials.gov/show/NCT01359878. Published protocol: http://www.trialsjournal.com/content/pdf/1745-6215-13-110.pdf.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, a randomized, placebo-controlled trial explored the preemptive use of fibrinogen concentrates in bleeding pregnant patients with hypofibrinogenemia (106). The study, which included 249 subjects, found that preemptive use did not reduce the risk of blood transfusion.”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [106]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pregnancy and Laboratory Studies
Abbassi-Ghanavati, M., Greer, L. G., & Cunningham, F. G. (2009) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181c2bde8 · Cited by 826
The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage
CHARBIT, B., MANDELBROT, L., SAMAIN, E., BARON, G., HADDAOUI, B., KEITA, H., SIBONY, O., MAHIEU‐CAPUTO, D., HURTAUD‐ROUX, M. F., HUISSE, M. G., et al. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02297.x · Cited by 762
Epidemiology of postpartum haemorrhage: a systematic review
Carroli, G., Cuesta, C., Abalos, E. J., & Gülmezoglu, A. M. (2008) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2008.08.004 · Cited by 550
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy
Levy, J. H., Welsby, I. J., & Goodnough, L. T. (2013) · Transfusion · doi:10.1111/trf.12431 · Cited by 329
Cortet, M., Deneux‐Tharaux, C., Dupont, C., Colin, C., Rudigoz, R.-C., Bouvier‐Colle, M., & Huissoud, C. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes096 · Cited by 303
Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery
Karlsson, M., Ternström, L., Hyllner, M., Baghaei, F., Flinck, A., Skrtic, S., & Jeppsson, A. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-09-0587 · Cited by 241
Eriksen, C. F., Jensen, T., Kristensen, B. S., Jensen, K. M., Tønnesen, E., Ingerslev, J., & Sørensen, B. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03331.x · Cited by 235
Standard haemostatic tests following major obstetric haemorrhage
de Lloyd, L., Bovington, R., Kaye, A., Collis, R. E., Rayment, R., Sanders, J., Rees, A., & Collins, P. W. (2011) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2010.12.002 · Cited by 213
Lowe, G. D. O., Rumley, A., & Mackie, I. J. (2004) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/0004563042466884 · Cited by 174
Bell, S., Rayment, R., Collins, P., & Collis, R. E. (2010) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2009.08.004 · Cited by 156
Cited by
Sorted by citations
Management of severe perioperative bleeding
Kozek‐Langenecker, S. A., Ahmed, A. B., Afshari, A., Albaladejo, P., Aldecoa, C., Barauskas, G., ROBERTIS, E. D., Faraoni, D., Filipescu, D. C., Fries, D. R., et al. (2017) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000630 · Cited by 817
Self-citationPrevention and Management of Postpartum Haemorrhage
(2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14178 · Cited by 785
Kietaibl, S. A., Ahmed, A. B., Afshari, A., Albaladejo, P., Aldecoa, C., Barauskas, G., ROBERTIS, E. D., Faraoni, D., Filipescu, D. C., Fries, D. R., et al. (2023) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001803 · Cited by 363
Self-citationThe role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management
Görlinger, K., Ferrer, A. P., Dirkmann, D., Saner, F. H., Maegele, M., Pérez-Calatayud, Á. A., & Kim, T. (2019) · Korean Journal of Anesthesiology · doi:10.4097/kja.19169 · Cited by 260
A practical guideline for the haematological management of major haemorrhage
Hunt, B. J., Allard, S., Keeling, D. M., Norfolk, D. R., Stanworth, S. J., & Pendry, K. (2015) · British Journal of Haematology · doi:10.1111/bjh.13580 · Cited by 252
Metadata
- Authors
- Wikkelsø, A. J., Edwards, H. M., Afshari, A., Stensballe, J., Langhoff-Roos, J., Albrechtsen, C., Ekelund, K., Hanke, G., Secher, E. L., Sharif, H. F., Pedersen, L. M., Troelstrup, A., Lauenborg, J., Mitchell, A. U., Fuhrmann, L., Svare, J., Madsen, M. G., Bødker, B., Møller, A. M., Wikkelsø, A., Edwards, H., Afshari, A., Stensballe, J., Langhoff-Roos, J., Møller, A. M., Albrechtsen, C., Ekelund, K., Hanke, G., Sharif, H. F., Secher, E. L., Christensen, M., Ramsing, B. U., Jensen-Gadegaard, P., Engskov, A., Wulff, C., Berntsen, M., Andersen, K. J., Classen, V., Opstrup, P., Lundstrøm, L. H., Flindt, M. S., Lunde, J., Pedersen, L. M., Troelstrup, A., Lauenborg, J., Lassen, B., Andersson, M., Winther-Olsen, M., Hougaard, S., Andersen, C., Petersen, M., Mitchell, A., Fuhrmann, L., Svare, J., Nielsen, C. V., Lefort Sønderskov, M., Winkel, R., Johansen, M., Søgaard, M., Madsen, M. G., Bødker, B., Okkels, C., Berthelsen, R., Elisabeth Linnet, K., Stendall, L., Darfeld, I., Madsen, M., & Pedersen, L.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Wikkelsø, A.J.
- ORCID
- Venue
- British Journal of Anaesthesia
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 114
- Issue
- 4
- Pages
- 623-633
- ISSN
- 0007-0912 (ISSN-L)
- OpenAlex
- W2140967888
- Cited by
- 267
- References
- 25
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 25 · 2023: 24 · 2022: 20 · 2021: 19 · 2020: 18 · 2019: 23 · 2018: 21 · 2017: 32 · 2016: 27 · 2015: 21
- FWCI
- 33.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- British Journal of Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- The Danish (10-084494)
- Council for Independent Research (17-12-1981)
- | Medical sciences
- Region Hovedstadens Sundhedsvidenskabelige Forskningsfond; Forskningsrådet Herlev Hospital
- Laerdals Acute Foundation; Aase og Ejnar Danielsens Fond
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Keywords
- postpartum hemorrhage, fibrinogen concentrate, preemptive therapy, red blood cell transfusion, fibrinogen, rebleeding, hemoglobin, blood loss, maternal mortality, thromboembolic events, obstetric hemorrhage management, hysterectomy, angiographic embolization, thrombocytopenia, thrombocytopenic purpura, thrombocytopenic thrombosis
- MeSH terms
- Double-Blind Method, Female, Fibrinogen, Postpartum Hemorrhage, Hemostasis, Humans, Pregnancy, Treatment Outcome, Erythrocyte Transfusion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
