Cited by 762Maternal and fetal healthcareBlood Coagulation and Thrombosis MechanismsBlood transfusion and management

The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage

Open access
CHARBIT, B., MANDELBROT, L., SAMAIN, E., BARON, G., HADDAOUI, B., KEITA, H., SIBONY, O., MAHIEU‐CAPUTO, D. +4 more·2007·Journal of Thrombosis and Haemostasis

Abstract

Background Postpartum hemorrhage (PPH) is a major source of maternal morbidity.Objectives This study's objective was to determine whether changes in hemostasis markers during the course of PPH are predictive of its severity.Patients and methods We enrolled 128 women with PPH requiring uterotonic prostaglandin E2 (sulprostone) infusion. Two groups were defined (severe and non-severe PPH) according to the outcome during the first 24 hours. According to our criteria, 50 of the 128 women had severe PPH. Serial coagulation tests were performed at enrollment (H0), and 1, 2, 4 and 24 hours thereafter.Results At H0, and through H4, women with severe PPH had significantly lower fibrinogen, factor V, antithrombin activity, protein C antigen, prolonged prothrombin time, and higher D-dimer and TAT complexes than women with non-severe PPH. In multivariate analysis, from H0 to H4, fibrinogen was the only marker associated with the occurrence of severe PPH. At H0, the risk for severe PPH was 2.63-fold higher for each 1 gL(-1) decrease of fibrinogen. The negative predictive value of a fibrinogen concentration >4 gL(-1) was 79% and the positive predictive value of a concentration <or=2 gL(-1) was 100%.Conclusion These findings indicate that a simple fibrinogen measurement can anticipate the risk of severe bleeding in PPH.

Integrity signals

Registry

Crossref · 10.1111/j.1538-7836.2007.02297.x

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
CHARBIT, B., MANDELBROT, L., SAMAIN, E., BARON, G., HADDAOUI, B., KEITA, H., SIBONY, O., MAHIEU‐CAPUTO, D., HURTAUD‐ROUX, M. F., HUISSE, M. G., DENNINGER, M. H., & DE PROST, D.
Affiliations
  • Hôpital Beaujon (FR)
  • Hôpital Louis-Mourier (FR)
  • Centre Hospitalier Universitaire de Besançon (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
Venue
Journal of Thrombosis and Haemostasis
Publisher
Elsevier BV
Published
2007-02
Volume
5
Issue
2
Pages
266-273
ISSN
1538-7836 (ISSN-L)
OpenAlex
W1993947427
Cited by
762
References
26
Citations by year
2026: 49 · 2025: 30 · 2024: 42 · 2023: 40 · 2022: 50 · 2021: 40 · 2020: 33 · 2019: 49 · 2018: 42 · 2017: 45 · 2016: 57 · 2015: 46 · 2014: 51 · 2013: 43 · 2012: 43
FWCI
20.93
Type
journal article
Language
en
Open access
Locations
  • Journal of Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
Keywords
postpartum hemorrhage, fibrinogen, hemostasis markers, severity prediction, coagulation tests, D-dimer, thrombin-antithrombin complex, factor V, antithrombin III, protein C, prothrombin time, sulprostone, maternal morbidity
MeSH terms
Adult, Blood Coagulation Tests, Female, Fibrinogen, Postpartum Hemorrhage, Humans, Predictive Value of Tests, Pregnancy, Severity of Illness Index, Time Factors, Dinoprostone, Biomarkers, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review