Joint exposure to multiple air pollutants, genetic risk and incident psoriasis: a large-scale prospective cohort study
Abstract
Background Air pollution and genetic risk have been found to contribute to the onset and development of psoriasis. However, the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of incident psoriasis remains unknown. Objectives To assess the association between joint exposure to multiple air pollutants and the risk of psoriasis, and its modification, according to genetic susceptibility. Methods This prospective study included 451 064 participants from the UK Biobank who had complete air pollution data and were free of psoriasis at baseline. All participants were enrolled from 2006 to 2010 and followed up to 2022. An air pollution score (APS) was calculated to assess joint exposure to multiple air pollutants, including fine particulate matter (PM) with diameters ≤ 2.5 μm (PM2.5), between 2.5 and 10 μm (PM2.5-10) and ≤ 10 μm (PM10), as well as nitrogen dioxide (NO2) and nitrogen oxides (NOx). To evaluate the genetic risk, a polygenic risk score (PRS) for psoriasis was constructed. Cox proportional hazard models were used to assess the association of air pollution and genetic susceptibility with the risk of psoriasis. Stratified analyses were conducted based on the individual characteristics. Results During a median follow-up of 13.79 years (range 0.00-16.81), 4414 cases of psoriasis were recorded. The hazard ratios (HRs) for psoriasis were 1.036 [95% confidence interval (CI) 0.936-1.147], 1.091 (95% CI 0.987-1.206), 1.159 (95% CI 1.048-1.…
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Only eight included studies used other exposures such as air pollution mixture, industrial air pollution, solid fuel pollution, and hydrocarbons.
“Only eight studies have used other exposures, such as AP mixture, industrial AP, solid fuel pollution, and hydrocarbons [32–36].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [34]
The long-term association of psoriasis was mainly stronger with particulate pollutants.
“while the long-term association of psoriasis was mainly stronger with particulate pollutants [34, 70].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [34]
Cites
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Air pollution and skin diseases: A comprehensive evaluation of the associated mechanism.
Gu, X., Li, Z., & Su, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116429 · Cited by 91 · see citing works
Transcriptome analysis of airborne PM 2.5-induced detrimental effects on human keratinocytes
Kim, H.-J., Bae, I.-H., Son, E. D., Park, J., Cha, N., Na, H.-W., Jung, C., Go, Y.-S., Kim, D.-Y., Lee, T. R., et al. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.03.010 · Cited by 58 · see citing works
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Zieneldien, T., Ma, S., Tan, I. J., Kim, J., Busot, D., & Cohen, B. A. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22121820 · Cited by 7 · see citing works
Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence
Singh, N., Schikowski, T., & Krutmann, J. (2026) · American Journal of Clinical Dermatology · doi:10.1007/s40257-026-01006-5 · Cited by 4 · see citing works
“…of association, or a change in the significance level when multiple pollutants are taken into account together in the regression model [14, 33, 34, 48, 54, 63, 68, 69, 71, 80, 98, 99], while a handful of studies have reported that the effect remained steady and significant [29, 71, 77, 81].”
- Authors
- Xiong, Y., Xia, Y., Zhang, X., Jiang, B., Zhang, Z., Xie, C., Miao, X., Lan, J., & Tao, J.
- Affiliations
- Wuhan Union Hospital (CN)
- Central South University (CN)
- Guizhou University (CN)
- Wuhan University (CN)
- Corresponding author
- Tao, Juan
- ORCID
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2024-10-12
- Volume
- 192
- Issue
- 3
- Pages
- 420-429
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W4403352496
- Cited by
- 19
- References
- 3
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 1
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82130089, 82103730)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- psoriasis, air pollution, PM2.5, PM2.5-10, PM10, nitrogen dioxide, nitrogen oxides, polygenic risk score, genetic susceptibility, gene-environment interaction, incident disease risk, UK Biobank
- MeSH terms
- Adult, Aged, Air Pollutants, Air Pollution, Environmental Exposure, Female, Follow-Up Studies, United Kingdom, Humans, Male, Middle Aged, Nitrogen Dioxide, Prospective Studies, Psoriasis, Risk Factors, Incidence, Genetic Predisposition to Disease, Particulate Matter, Gene-Environment Interaction
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