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Perinatal psychiatric disorders: a leading cause of maternal morbidity and mortality
Abstract
The Confidential Enquiry into Maternal Deaths 1997 to 1999 finds that psychiatric disorder, and suicide in particular, is the leading cause of maternal death. Suicide accounted for 28% of maternal deaths. Women also died from other complications of psychiatric disorder and a significant minority from substance misuse. Some of the findings of the Confidential Enquiry confirm long established knowledge about postpartum psychiatric disorder. The findings highlight the severity and early onset of serious postpartum mental illness and of the risk of recurrence following childbirth faced by women with a previous history of serious mental illness either following childbirth or at other times. These findings led to the recommendation that all women should be asked early in their pregnancy about a previous history of serious psychiatric disorder and that management plans should be in place with regard to the high risk of recurrence following delivery. Other findings of the Enquiry were new and challenged some of the accepted wisdoms of obstetrics and psychiatry. It is likely that the suicide rate following delivery is not significantly different to other times in women's lives and for the first 42 days following delivery may be elevated. This calls into question the so-called 'protective effect of maternity'. The overwhelming majority of the suicides died violently, contrasting with the usual finding that women are more likely to die from an overdose of medication. Compared to other causes of maternal death, the suicides were older and socially advantaged. The Enquiry findings suggest that the risk profile for women at risk of suicide following delivery may be different to that in women at other times and in men. None of the women who died had been admitted at any time to a Mother and Baby Unit and their psychiatric care had been undertaken by General Adult Services. None of the women who died had had a previous episode correctly identified and none had had adequate plans for their proactive care. The conclusion is that there is a need for both Psychiatry and Obstetrics to acknowledge the substantial risk that women with a previous psychiatric history of serious mental illness face following delivery.
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“Suicide has been identified as a leading cause of maternal death in some developed countries [41]”
From The global prevalence of postpartum psychosis: a systematic review (2017) · cites this paper as [41]
In the citing paper
“Psychological distress among perinatal women correlates with increased maternal morbidity and mortality rates (Khalifa et al., 2016; Oates, 2003), poor infant health outcomes (Gelaye et al., 2016), and adverse early childhood developmental trajectories encompassing cognitive, emotional, and developmental delays (Slomian et al., 2019), making it a substantial public health concern.”
From Developing and validating the Sierra Leone perinatal psychological distress scale through an emic-etic approach (2025) · cites this paper as Oates, 2003
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“Given that (1) suicide during pregnancy is one of the leading causes of maternal mortality (Oates, 2003; World Health Organization, 2008), and (2) there is an existing gap in research investigating perinatal complications associated with suicidal ideation during pregnancy (Fuhr et al., 2014; World…”
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“The combination of psychosis, lapsed insight and poor judgment can lead to devastating consequences whereby the safety and well-being of the mother and her baby are jeopardized (Friedman, Horwitz, & Resnick, 2005; Hornstein, TrautmannVillalba, Hohm, Rave, Wortmann-Fleischer, & Schwarz, 2006; Oates, 2003; Seeman, 2004;…”
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“Recent research indicates that the leading cause of maternal mortality is violent suicide, disproportionately arising from under-treated postpartum depression (Oates, 2003).”
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“At the same time, it provides a unique opportunity for the identification of mental health issues and for provision of primary, secondary, and tertiary services (Buist et al., 2002, 2006; Oates, 2003).”
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BackgroundInfluentialPREVALENCE AND ASSOCIATED FACTORS OF SUICIDE AMONG PREGNANT WOMEN AT ZAGAZIG UNIVERSITY HOSPITALS
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“DIsCussIOn Accurate identification and treatment of mental illnesses that may become life-threatening during the perinatal period is an important quality and safety issue and crucial to reducing the maternal death rate.(14) 15 This study illustrates several inter-related barriers to detection, response and escalation…”
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“PD may present with suicidal ideation, and suicide is a leading cause of maternal deaths (Oates 2003).”
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“This results in decreased emotional involvement and hostility toward newborns.(15) CMDs during pregnancy may also be associated with child malnutrition,(16) and affect a child’s behavioral,(17) emotional, and cognitive development.”
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“…with perinatal depression are at increased risk for peripartum haemorrhage, preterm birth, stillbirth, and suicide; with suicide becoming one of the leading causes of maternal mortality in high-income countries where other common obstetric causes of maternal mortality are largely controlled [7].”
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Sihre, H. K., Gill, P. S., Lindenmeyer, A., McGuiness, M., Berrisford, G. S., Janković, J., Patel, M., Lewin, J., & Fazil, Q. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025928 · Cited by 7
Dutta, G. K., Ahmed, H. U., Talukder, M. Q., Bhattacharyya, D. S., Reza, M. S., Rahman, M. M., Majumdar, R., Tofail, F., Perry, H. B., & Biswas, T. K. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104290 · Cited by 6
Postpartum Psychosis after Traumatic Cesarean Delivery
Antoniou, E., Orovou, E., Politou, K., Papatrechas, A., Palaska, E., Sarella, A., & Dagla, M. (2021) · Healthcare · doi:10.3390/healthcare9050588 · Cited by 9
“Although suicide is rare, it is one of the leading causes of maternal death [15,24].”
BackgroundSilva, T., Ferreira, S. R., Esteves, P. S., & Cerejeira, J. (2022) · BMJ Case Reports · doi:10.1136/bcr-2021-246199 · Cited by 6
“Everything Is Greyscaled”: Immigrant Women’s Experiences of Postpartum Distress
Yu, Z., & Bowers, B. J. (2020) · Qualitative Health Research · doi:10.1177/1049732320914868 · Cited by 10
“Suicide during the postpartum period is a leading cause of maternal mortality (Khalifeh et al., 2016; Oates, 2003).”
BackgroundEvidence‐Based Treatments and Pathways to Care
O’Hara, M. W., Dennis, C., McCabe, J. E., & Galbally, M. (2015) · Wiley eBooks · doi:10.1002/9781118509722.ch11 · Cited by 7
Hernández‐Vásquez, A., Vargas‐Fernández, R., Chavez‐Ecos, F. A., Mendoza-Correa, I., & Sara, J. C. D. C. (2022) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2022.101879 · Cited by 5
“2 disorder remains underestimated and with low access to treatment (Oates, 2003).”
BackgroundInfluentialDoherty, A. M., Crudden, G., Jabbar, F., Sheehan, J. D., & Casey, P. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16203970 · Cited by 6
“Up to one third of maternal deaths are associated with suicide [9,23,24].”
BackgroundDecisional Capacity in Pregnancy: A Complex Case of Pregnancy Termination
Zalpuri, I., Byatt, N., Gramann, S. B., Dresner, N., & Brendel, R. W. (2014) · Psychosomatics · doi:10.1016/j.psym.2014.09.009 · Cited by 5
“The prevailing standard for the determination of decisional capacity regarding medical care relies on the presence of 4 key components: (1) ability to communicate a choice, (2) ability to understand relevant information (factual understanding), (3) ability to appreciate the nature of the situation and its likely conse…”
BackgroundThe relationship between intimate partner violence and postpartum depression in Osogbo, Nigeria
Mapayi, B. M., Benjamin, A. A., Mosanya, J. T., & Adeomi, A. A. (2018) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20184113 · Cited by 5
“As a result, there is need for more knowledge about the role of IPV as a risk factor in postpartum depression.(17)”
BackgroundAssociations of antepartum suicidal behaviour with adverse infant and obstetric outcomes
Zhong, Q., Gelaye, B., Karlson, E. W., Avillach, P., Smoller, J. W., Cai, T., & Williams, M. A. (2019) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12535 · Cited by 5
Césarienne et sismothérapie concomitante chez une patiente psychotique sévère : à propos d’un cas
Vermersch, C., Smadja, S., Amselem, O., Gay, O., Marcellin, L., Raphaël Gaillard, B., & Mignon, A. (2013) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2013.07.808 · Cited by 5
The use of psychotropic medications with breastfeeding women: Applying the available evidence
Usher, K. J., & Foster, K. (2006) · Contemporary Nurse · doi:10.5172/conu.2006.21.1.94 · Cited by 5
“In fact, 10% to 15% of all postpartum women will develop some form of mental illness (Winans 2001; Oates 2003), and women with a pre-existing condition are at an even higher risk of developing a relapse of their condition in the postnatal period (Ilett et al.”
BackgroundSuicide deaths among reproductive-aged women in the US post-Dobbs: a national time-series analysis
Singh, P., Crawford, A., Crow, S. E., Powell, J. R., & Gallo, M. F. (2025) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-025-02902-7 · Cited by 4
“The provision of mental health care to those with the capacity for pregnancy, particularly younger people, is critical given that psychiatric comorbidities are one of the leading risk factors for maternal mortality [67–69].”
Cognitive Behavioral Therapy for Depression
Todd, G., & Branch, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108355605.021 · Cited by 5
Bergink, V., & Kushner, S. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-54562-7_10 · Cited by 4
Little, E., Bain, L., & Hahn‐Holbrook, J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.044 · Cited by 4
Punj, P., Arora, A., Shah, R., Patil, A., Sikka, P., Jain, V., Suri, V., & Saini, S. S. (2023) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1319_23 · Cited by 4
“[6] However, not many of these consider patients who had a critical event in the peri‑partum period (Oates, 2003).”
BackgroundAnke, T. M. S., & Skjelstad, D. V. (2025) · International Journal of Bipolar Disorders · doi:10.1186/s40345-025-00374-x · Cited by 6
“…perinatal suicides are rare in the general population, perinatal suicidal ideation is considered a risk factor for suicidal behaviour (Orsolini et al. 2016), and postpartum women with severe depression and psychosis are at particular risk (Johannsen et al. 2016; Khalifeh et al. 2016; Oates 2003).”
A Public Health Approach to Addressing Perinatal Depression
Perry, D. F., Nicholson, W. K., Christensen, A. L., & Riley, A. W. (2011) · International Journal of Mental Health Promotion · doi:10.1080/14623730.2011.9715657 · Cited by 4
Mental Health and Behavioral Disorders in Pregnancy
Wisner, K. L., Sit, D. K. Y., Bogen, D. L., Altemus, M. M., Pearlstein, T. B., Svikis, D. S., Misra, D. P., & Miller, E. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-32108-2.00055-x · Cited by 4
Prevalence and Correlates of Postpartum Depression in Osogbo, Nigeria
Deborah, A. A., Benjamin, A. A., & Akinsulore, A. (2019) · International Neuropsychiatric Disease Journal · doi:10.9734/indj/2018/v12i330097 · Cited by 4
“In severe depression, especially in the presence of psychotic symptoms, there is a risk of suicide and infanticide [6].”
BackgroundPregnancy, Mental Well-Being and Lockdown: A Nationwide Online Survey in France
Gaucher, L., Barasinski, C., Dupont, C., Razurel, C., Pichon, S., Leavy, E., Savelon, S. V., Cortet, M., Nicolas Franck, B., Haesebaert, F., et al. (2022) · Healthcare · doi:10.3390/healthcare10101855 · Cited by 4
“In some Western countries, suicides are one of the main causes of maternal deaths [1,2].”
Metadata
- Authors
- Oates, M.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Oates, Margaret
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 67
- Issue
- 1
- Pages
- 219-229
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2137670496
- Cited by
- 317
- References
- 16
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 16 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 17 · 2019: 22 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 21 · 2014: 21 · 2013: 18 · 2012: 12
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Medical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- perinatal psychiatric disorders, maternal mortality, maternal suicide, postpartum mental disorders, severe mental illness, substance abuse, confidential enquiry into maternal deaths, maternal morbidity
- MeSH terms
- Female, Humans, Maternal Mortality, Pregnancy, Psychotic Disorders, Puerperal Disorders, Recurrence, Risk, Suicide
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