The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Pre-emptive analgesia
Abstract
Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization. Owing to this 'protective' effect on the nociceptive system, pre-emptive analgesia has the potential to be more effective than a similar analgesic treatment initiated after surgery. Theoretically, immediate postoperative pain may be reduced and the development of chronic pain may be prevented. Although some clinical studies have demonstrated significant effects on acute postoperative pain, no major clinical benefits of pre-emptive analgesia have been documented. The only way to prevent sensitization of the nociceptive system might be to block completely any pain signal originating from the surgical wound from the time of incision until final wound healing. Other pharmacological interventions, including 'antihyperalgesic' drugs such as NMDA-receptor antagonists and gabapentin, may interfere with the induction and maintenance of sensitization. Future studies will investigate the analgesic effect of prolonged multimodal combinations of different classes of 'traditional' analgesics and 'antihyperalgesics' on postoperative pain.
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Citations
Cites
Neuronal plasticity: Increasing the gain in pain
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Anaesthesia, surgery, and challenges in postoperative recovery
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Self-citationMøiniche, S., Kehlet, H., & Dahl, J. B. (2002) · Anesthesiology · doi:10.1097/00000542-200203000-00032 · Cited by 815
Self-citationThe prevention of postoperative pain
Wall, P. D. (1988) · Pain · doi:10.1016/0304-3959(88)90286-2 · Cited by 731
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Ketamine as Adjuvant Analgesic to Opioids: A Quantitative and Qualitative Systematic Review
Subramaniam, K., Subramaniam, B., & Steinbrook, R. A. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000118109.12855.07 · Cited by 504
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Self-citationEpidural block with mepivacaine before surgery reduces long-term post-thoracotomy pain
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Cited by
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Hah, J. M., Bateman, B. T., Ratliff, J., Curtin, C., & Sun, E. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002458 · Cited by 728
Kraychete, D. C., Sakata, R. K., Lannes, L. D. O. C., Bandeira, I. D., & Sadatsune, E. J. (2016) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjan.2014.12.002 · Cited by 32
Pain in an era of armed conflicts: prevention and treatment for warfighters and civilian casualties
George, E., Elman, I., Becerra, L., Berg, S., & Borsook, D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.002 · Cited by 18
Metadata
- Authors
- Dahl, J. B., & Møiniche, S.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2004
- Volume
- 71
- Issue
- 1
- Pages
- 13-27
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2136909022
- Cited by
- 316
- References
- 23
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
