The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
‘Protective premedication’: an option with gabapentin and related drugs?: A review of gabapentin and pregabalin in the treatment of post‐operative pain
Abstract
Substantial progress has been made during the last decades in our understanding of acute pain mechanisms, and this knowledge has encouraged the search for novel treatments. Of particular interest has been the observation that tissue injury initiates a number of modulations of both the peripheral and the central pain pathways, which convert the system from a ‘physiological’ to a ‘pathological’ mode of processing afferent information. Gabapentin, which binds to the α 2 δ subunit of the voltage‐dependent calcium channel, is active in animal models of ‘pathological’ but not in models of ‘physiological’ pain. Consequently, attention has so far been focused on neuropathic pain as a target for the clinical use of gabapentin and analogues. Recently, several reports have indicated that gabapentin may have a place in the treatment of post‐operative pain. This article presents a brief summary of the potential mechanisms of post‐operative pain, and a systematic review of the available data of gabapentin and pregabalin for post‐operative analgesia. It is concluded that the results with gabapentin and pregabalin in post‐operative pain treatment published so far are promising. It is suggested that future studies should explore the effects of ‘protective premedication’ with combinations of various antihyperalgesic and analgesic drugs for post‐operative analgesia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 3×
“This is mediated by a decrease in inhibitory input or an increase in synaptic efficacy or membrane excitability, triggered by wind-up, neurokinin and N-methyl-D-aspartic acid (NMDA)receptor mechanisms (1, 3).”
BackgroundBackonja, M. (1998) · JAMA · doi:10.1001/jama.280.21.1831 · Cited by 1,533
Rowbotham, M. (1998) · JAMA · doi:10.1001/jama.280.21.1837 · Cited by 1,433
Scholz, J., & Woolf, C. J. (2002) · Nature Neuroscience · doi:10.1038/nn942 · Cited by 835
Møiniche, S., Kehlet, H., & Dahl, J. B. (2002) · Anesthesiology · doi:10.1097/00000542-200203000-00032 · Cited by 815
Self-citationA summary of mechanistic hypotheses of gabapentin pharmacology
Taylor, C. P., Gee, N. S., Su, T.-Z., Kocsis, J. D., Welty, D. F., Brown, J. P., Dooley, D. J., Boden, P., & Singh, L. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(97)00084-3 · Cited by 774
Pregabalin for the treatment of postherpetic neuralgia: A randomized, placebo-controlled trial
Dworkin, R. H., Corbin, A. E., Young, J. P., Sharma, U., LaMoreaux, L., Bockbrader, H., Garofalo, E. A., & Poole, R. M. (2003) · Neurology · doi:10.1212/01.wnl.0000055433.55136.55 · Cited by 768
The prevention of postoperative pain
Wall, P. D. (1988) · Pain · doi:10.1016/0304-3959(88)90286-2 · Cited by 731
Carr, D. B., & Goudas, L. C. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03313-9 · Cited by 653
Cited by
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Recommendations for the management of herpes zoster
Dworkin, R. H., Johnson, R. W., Breuer, J., Gnann, J. W., Levin, M. J., Backonja, M., Betts, R. F., Gershon, A. A., Haanpää, M. L., McKendrick, M. W., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/510206 · Cited by 869
Efficacy of pregabalin in acute postoperative pain: a meta-analysis
Zhang, J., Ho, K.-Y., & Wang, Y. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer027 · Cited by 357
Dahl, J. B., & Møiniche, S. (2005) · British Medical Bulletin · doi:10.1093/bmb/ldh030 · Cited by 316
Self-citationDurmus, M., Kadir But, A., Saricicek, V., Ilksen Toprak, H., & Ozcan Ersoy, M. (2007) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2006.01237.x · Cited by 60
Metadata
- Authors
- Dahl, J. B., Mathiesen, O., & Møiniche, S.
- Venue
- Acta Anaesthesiologica Scandinavica
- Publisher
- Wiley
- Published
- 2004-09-07
- Volume
- 48
- Issue
- 9
- Pages
- 1130-1136
- ISSN
- 0001-5172 (ISSN-L)
- 1399-6576
- OpenAlex
- W1554799602
- Cited by
- 270
- References
- 36
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ‘Protective premedication’: an option with gabapentin and related drugs?: A review of gabapentin and pregabalin in the treatment of post‐operative pain. https://app.cochat.ai/papers/10.1111/j.1399-6576.2004.00484.x
- The paper
- Dahl, J. B., Mathiesen, O., & Møiniche, S. (2004). ‘Protective premedication’: an option with gabapentin and related drugs?: A review of gabapentin and pregabalin in the treatment of post‐operative pain. Acta Anaesthesiologica Scandinavica. https://doi.org/10.1111/j.1399-6576.2004.00484.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
