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VISUAL ACUITY AND CONTRAST SENSITIVITY IN MULTIPLE SCLEROSIS—HIDDEN VISUAL LOSS: AN AUXILIARY DIAGNOSTIC TEST
Abstract
In 48 patients with multiple sclerosis sine-wave gratings were used to test visual sensitivity for coarse, medium, and fine detail rather than measuring visual acuity for fine detail only, as in conventional clinical tests. In 20/48 patients the test revealed a visual defect of neural origin, qualitatively different from that caused by refractive error. In 11 of these 20 patients, visual sensitivity to detail of medium coarseness was markedly degraded, even though sensitivity to both coarse and fine detail was unimpaired. In 3 of these 20 patients visual sensitivity to coarse detail was selectively degraded. These visual defects could not be detected by the Snellen test, yet the patient might experience visual problems in everyday life and also experience distorted visual perception. Possible neural bases for these visual impairments are discussed. Since 8 of the 14 patients with selective loss showed no clinical evidence of visual involvement, the test can aid the earlier diagnosis of multiple sclerosis.
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Cited by
Relation of Visual Function to Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis
FISHER, J., JACOBS, D., MARKOWITZ, C., GALETTA, S., VOLPE, N., NANOSCHIAVI, M., BAIER, M., FROHMAN, E., WINSLOW, H., & FROHMAN, T. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2005.10.040 · Cited by 658
AGE VARIATIONS IN NORMAL HUMAN CONTRAST SENSITIVITY
DEREFELDT, G., LENNERSTRAND, G., & LUNDH, B. (1979) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1979.tb00517.x · Cited by 254
Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies
Guy, J., Mancuso, A., Quisling, R. G., Beck, R., & Moster, M. (1990) · Ophthalmology · doi:10.1016/s0161-6420(90)32537-x · Cited by 90
Metadata
- Authors
- REGAN, D., SILVER, R., & MURRAY, T. J.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1977
- Volume
- 100
- Issue
- 3
- Pages
- 563-579
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2512274464
- Cited by
- 254
- References
- 0
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: VISUAL ACUITY AND CONTRAST SENSITIVITY IN MULTIPLE SCLEROSIS—HIDDEN VISUAL LOSS: AN AUXILIARY DIAGNOSTIC TEST. https://app.cochat.ai/papers/10.1093/brain/100.3.563
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- REGAN, D., SILVER, R., & MURRAY, T. J. (1977). VISUAL ACUITY AND CONTRAST SENSITIVITY IN MULTIPLE SCLEROSIS—HIDDEN VISUAL LOSS: AN AUXILIARY DIAGNOSTIC TEST. Brain. https://doi.org/10.1093/brain/100.3.563
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