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THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION
Abstract
Conduction has been examined serially through the experimental demyelinating lesion produced by the direct micro-injection of lysophatidyl choline into the cat spinal cord. Conduction was blocked during the phase of demyelination. Remyelination commenced during the latter part of the second week, and conduction through the lesion was restored in some fibres at this time. The refractory period of transmission was initially prolonged. As remyelination proceeded, conduction was restored in increasing numbers of fibres. Within three months the responses were stable and the refractory periods of transmission had returned to normal even though the new internodes were still abnormally thin and were generally shorter than normal. Restoration of conduction by remyelination is likely to contribute to recovery from compressive and traumatic lesions of the central nervous system but probably plays little part in the remissions of multiple sclerosis.
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Cited by
Compston, A., & Coles, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08220-x · Cited by 1,743
Trigeminal neuralgia: Pathology and pathogenesis
Love, S. (2001) · Brain · doi:10.1093/brain/124.12.2347 · Cited by 866
Remyelination in Experimental Models of Toxin-Induced Demyelination
Blakemore, W. F., & Franklin, R. J. M. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-73677-6_8 · Cited by 275
Self-citationExtensive remyelination of the CNS leads to functional recovery
Duncan, I. D., Brower, A., Kondo, Y., Curlee, J. F., & Schultz, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812500106 · Cited by 227
Remyelinating strategies for the treatment of multiple sclerosis
Stangel, M., & Hartung, H.-P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00105-3 · Cited by 126
Metadata
- Authors
- SMITH, K. J., BLAKEMORE, W. F., & MCDONALD, W. I.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1981
- Volume
- 104
- Issue
- 2
- Pages
- 383-404
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2116532218
- Cited by
- 183
- References
- 0
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION. https://app.cochat.ai/papers/10.1093/brain/104.2.383
- The paper
- SMITH, K. J., BLAKEMORE, W. F., & MCDONALD, W. I. (1981). THE RESTORATION OF CONDUCTION BY CENTRAL REMYELINATION. Brain. https://doi.org/10.1093/brain/104.2.383
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
