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SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS
Abstract
Serial gadolinium-DTPA (Gd-DTPA) enhanced magnetic resonance imaging (MRI) was performed in 9 patients with multiple sclerosis (MS). On the first scan enhancing lesions were seen in 7 patients, all of whom were in acute relapse. Most enhancing lesions were asymptomatic. On the second scan (3 to 5 weeks later), persisting enhancement was seen in only 12/54 lesions which enhanced on the first scan. No lesion showed persisting enhancement on the third scan (after 6 months). Enhancement occurred in all 12 new lesion areas seen on the unenhanced second scan and in 8 of 15 new lesions seen on the third scan. Enhancement was also seen in 4 older lesions which had been nonenhancing on earlier scans. Relaxation time measurements demonstrated a high water content in some nonenhancing lesions, which could be due to a subtle blood-brain barrier disturbance not detected with Gd-DTPA. The results show that blood-brain barrier impairment is a consistent finding in new MS lesions detected with MRI. Gd-DTPA is a useful marker of new and biologically active lesions and should prove of value in monitoring therapeutic trials in MS.
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Citations
Cited by
Tofts, P. S., & Kermode, A. G. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910170208 · Cited by 1,456
Progressive multiple sclerosis: pathology and pathogenesis
Lassmann, H., van Horssen, J., & Mahad, D. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.168 · Cited by 1,033
A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011341 · Cited by 861
Self-citationDistinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis
Lucchinetti, C. F., Brück, W., Rodriguez, M., & Lassmann, H. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00854.x · Cited by 733
KERMODE, A. G., THOMPSON, A. J., TOFTS, P., MACMANUS, D. G., KENDALL, B. E., KINGSLEY, D. P. E., MOSELEY, I. F., RUDGE, P., & MCDONALD, W. I. (1990) · Brain · doi:10.1093/brain/113.5.1477 · Cited by 578
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Metadata
- Authors
- MILLER, D. H., RUDGE, P., JOHNSON, G., KENDALL, B. E., MACMANUS, D. G., MOSELEY, I. F., BARNES, D., & MCDONALD, W. I.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-08-01
- Volume
- 111
- Issue
- 4
- Pages
- 927-939
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2057549315
- Cited by
- 407
- References
- 0
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS. https://app.cochat.ai/papers/10.1093/brain/111.4.927
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- MILLER, D. H., RUDGE, P., JOHNSON, G., KENDALL, B. E., MACMANUS, D. G., MOSELEY, I. F., BARNES, D., & MCDONALD, W. I. (1988). SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS. Brain. https://doi.org/10.1093/brain/111.4.927
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
