The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T
Abstract
Histopathological reports of multiple sclerosis and its animal models have shown evidence of a link between axonal injury in active lesions and impaired glutamate metabolism. Mature oligodendrocytes play a role in glutamate uptake to maintain glutamate homeostasis but in multiple sclerosis white matter the loss of expression of glutamate transporters in the lesion vicinity results in ineffective glutamate removal. Using a magnetic resonance spectroscopy technique that isolates the glutamate resonance at 3 T, we compared glutamate levels between normal subjects and multiple sclerosis patients in different brain areas. Metabolite concentrations (glutamate, glutamine, N-acetyl-aspartate, myo-inositol, choline, creatine) were derived from LCmodel and corrected for T1 relaxation time. Glutamate concentrations were found to be elevated in acute lesions (P = 0.02) and normal-appearing white matter (P = 0.03), with no significant elevation in chronic lesions (P = 0.77). The N-acetyl-aspartate level in chronic lesions was significantly lower (P < 0.001) than in acute lesions and normal-appearing white matter. The choline level in acute lesions was significantly higher (P < 0.001) than in chronic lesions. Evidence was also found for increased glial activity in multiple sclerosis, with significantly higher (P < 0.001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients.
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Glutamate excitotoxicity in a model of multiple sclerosis
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Cited by
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
Trapp, B. D., & Stys, P. K. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70043-2 · Cited by 621
Centonze, D., Muzio, L., Rossi, S., Cavasinni, F., De Chiara, V., Bergami, A., Musella, A., D'Amelio, M., Cavallucci, V., Martorana, A., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5804-08.2009 · Cited by 390
Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement
Beart, P. M., & O'Shea, R. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706949 · Cited by 377
The Role of Astrocytes in Multiple Sclerosis
Ponath, G., Park, C., & Pitt, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00217 · Cited by 359
Metadata
- Authors
- Srinivasan, R., Sailasuta, N., Hurd, R., Nelson, S., & Pelletier, D.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03-09
- Volume
- 128
- Issue
- 5
- Pages
- 1016-1025
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2082688434
- Cited by
- 465
- References
- 42
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Srinivasan, R., Sailasuta, N., Hurd, R., Nelson, S., & Pelletier, D. (2005). Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain. https://doi.org/10.1093/brain/awh467
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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