Cited by 256Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMemory and Neural Mechanisms

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Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

Frisoni, G. B., Ganzola, R., Canu, E., Rub, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., Thompson, P. M.·2008·Brain

DOI 10.1093/brain/awn280

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Abstract

Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T(1)-weighted images were acquired from 19 Alzheimer's disease patients [age 76 +/- 6 years, three males, Mini-Mental State Examination 13 +/- 4] and 19 controls (age 74 +/- 5 years, 11 males, Mini-Mental State Examination 29 +/- 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P < 0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P < 0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing.

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Background
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Authors: Frisoni, G. B., Ganzola, R., Canu, E., Rub, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., & Thompson, P. M.
Affiliations: University of California, Los Angeles (US)
Goethe University Frankfurt (DE)
ORCID: Frisoni, G. B.
Ganzola, R.
Canu, E.
Pizzini, F. B.
Zoccatelli, G.
Caltagirone, C.
Thompson, P. M.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2008-11-06
Volume: 131
Issue: 12
Pages: 3266-3276
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awn280
OpenAlex: W2090537659
Cited by: 256
References: 53
Citations by year: 2026: 11 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 13 · 2020: 24 · 2019: 19 · 2018: 10 · 2017: 17 · 2016: 14 · 2015: 27 · 2014: 25 · 2013: 15 · 2012: 12
FWCI: 6.56
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Alzheimer's disease, normal aging, hippocampal atrophy, hippocampal subfields, CA1, presubiculum, hippocampal volume, T1-weighted imaging, 3T MRI
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain Mapping, Female, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales

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Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

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