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Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla
Abstract
Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T(1)-weighted images were acquired from 19 Alzheimer's disease patients [age 76 +/- 6 years, three males, Mini-Mental State Examination 13 +/- 4] and 19 controls (age 74 +/- 5 years, 11 males, Mini-Mental State Examination 29 +/- 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P < 0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P < 0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing.
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“the CA1 subfield was found significantly atrophic in a study that used the same automated method as ours and included patients with similar dementia severity [33] and in studies that used a procedure involving manual segmentation of hippocampal subfields [34], [35] or based on 3D surface reconstruction and shape analysis of the hippocampi [36], [37]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [36]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
American Journal of Neuroradiology
(2020) · American Journal of Neuroradiology · doi:10.3174/ajnr · Cited by 2,468
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Edgington, E. S., Edgington, E., & Onghena, P. (1964) · Springer eBooks · doi:10.1002/0471667196.ess2169 · Cited by 2,052
Pathological verification of ischemic score in differentiation of dementias
Rosen, W. G., Terry, R. D., Fuld, P. A., Katzman, R., & Peck, A. (1980) · Annals of Neurology · doi:10.1002/ana.410070516 · Cited by 1,273
Unbiased stereological estimation of the number of neurons in the human hippocampus
West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153 · cited 3×
“For example, pyramidal cells are lost in the subiculum between age 30 and 60 years (Trillo and Gonzalo, 1992), but stabilize thereafter (West and Gundersen, 1990; Trillo and Gonzalo, 1992), while cell loss in the presubiculum and CA1 subfield is more linearly associated with increasing age at least…”
BackgroundDynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132
Self-citation4 Histology and Histopathology
(2015) · Thieme eBooks · doi:10.1055/b-0035-108581 · Cited by 1,052
MR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease
Jack, C. R., Petersen, R. C., O’Brien, P. C., & Tangalos, E. G. (1992) · Neurology · doi:10.1212/wnl.42.1.183 · Cited by 880
共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値
Whittaker, P. G., Morgan, M. R., Dean, P., Cameron, E., & Lind, T. (1980) · The Lancet · Cited by 724
Pruessner, J. C. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.4.433 · Cited by 706
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1998) · Neurology · doi:10.1212/wnl.51.4.993 · Cited by 666
Mapping hippocampal and ventricular change in Alzheimer disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G. I., Janke, A. L., Rose, S., Semple, J. M., Hong, M., Herman, D. H., Gravano, D. M., Doddrell, D. M., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.040 · Cited by 618
Self-citationDuvernoy, H. M., Cattin, F., & Risold, P. (2013) · Springer eBooks · doi:10.1007/978-3-642-33603-4 · Cited by 569
Conversion of Mild Cognitive Impairment to Alzheimer Disease Predicted by Hippocampal Atrophy Maps
Apostolova, L. G., Dutton, R. A., Dinov, I. D., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.693 · Cited by 553
Self-citationMurphy, D. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070031007 · Cited by 527
Sex Differences in Brain Aging
Coffey, C. E., Lucke, J. F., Saxton, J. A., Ratcliff, G. G., Unitas, L. J., Billig, B. K., & Bryan, R. N. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.169 · Cited by 446
A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA
Ball, M. J., Hachinski, V., Fox, A. J., Kirshen, A. J., Fisman, M., Blume, W. T., Kral, V. A., Fox, H., & Merskey, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90965-1 · Cited by 427
Segregating the functions of human hippocampus
Strange, B. A., Fletcher, P. C., Henson, R. N., Friston, K. J., & Dolan, R. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4034 · Cited by 334
Hippocampal Atrophy in Normal Aging
Golomb, J. B. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540090066012 · Cited by 323
Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood
Pruessner, J. C., Collins, D. L., Pruessner, M., & Evans, A. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00194.2001 · Cited by 292
Organization of CA1 projections to the subiculum: A PHA‐L analysis in the rat
Amaral, D. G., Dolorfo, C. L., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010410 · Cited by 272
Regional specificity of hippocampal volume reductions in first-episode schizophrenia
Narr, K. L., Thompson, P. M., Szeszko, P. R., Robinson, D. G., Jang, S., Woods, R. P., Kim, S. H., Hayashi, K. M., Asunction, D., Toga, A. W., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.011 · Cited by 265
Self-citationWang, L., Swank, J. S., Glick, I. E., Gado, M. H., Miller, M. I., Morris, J. C., & Csernansky, J. G. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00361-6 · Cited by 263
Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology
Schönheit, B., Zarski, R., & Ohm, T. G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.009 · Cited by 262
Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus
Csernansky, J. G., Wang, L., Joshi, S. C., Miller, J. P., Gado, M., Kido, D. K., McKeel, D. W., Morris, J. C., & Miller, M. I. (2000) · Neurology · doi:10.1212/wnl.55.11.1636 · Cited by 259
Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats
Shapiro, L. A., Wang, L., & Ribak, C. E. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01491.x · Cited by 242
Thompson, P. M., Schwartz, C., & Toga, A. W. (1996) · NeuroImage · doi:10.1006/nimg.1996.0003 · Cited by 226
Self-citationMorra, J. H., Tu, Z., Apostolova, L. G., Green, A. E., Avedissian, C., Madsen, S. K., Parikshak, N., Hua, X., Toga, A. W., Jack, C. R., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.003 · Cited by 202
Self-citationChapter 32 Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease
Hoesen, G. W. V., & Hyman, B. T. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61268-6 · Cited by 201
Laakso, M. P., Frisoni, G. B., Könönen, M., Mikkonen, M., Beltramello, A., Geroldi, C., Bianchetti, A., Trabucchi, M., Soininen, H. S., & Aronen, H. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00306-6 · Cited by 185
Self-citationHua, X., Leow, A., Lee, S., Klunder, A. D., Toga, A. W., Leporé, N., Chou, Y.-Y., Brun, C., Chiang, M. Y.-H., & Marina Barysheva, A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.010 · Cited by 175
Abnormalities of hippocampal surface structure in very mild dementia of the Alzheimer type
Wang, L., Miller, J. P., Gado, M. H., McKeel, D. W., Rothermich, M. A., Miller, M. I., Morris, J. C., & Csernansky, J. G. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.017 · Cited by 171
Leow, A., Huang, S., Geng, A., Becker, J. T., Davis, S. W., Toga, A. W., & Thompson, P. M. (2005) · Lecture notes in computer science · doi:10.1007/11505730_41 · Cited by 170
Self-citationHippocampus Volume Loss Due to Chronic Heavy Drinking
Beresford, T. P., Arciniegas, D. B., Alfers, J., Clapp, L., Martin, B., Du, Y., Liu, D., Shen, D., & Davatzikos, C. (2006) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00223.x · Cited by 158
Detection and mapping of hippocampal abnormalities in autism
Nicolson, R., DeVito, T. J., Vidal, C. N., Sui, Y., Hayashi, K. M., Drost, D. J., Williamson, P., Rajakumar, N., Toga, A. W., & Thompson, P. M. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.02.005 · Cited by 130
Self-citationIn vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study
Frisoni, G. B., Sabattoli, F., Lee, A. D., Dutton, R. A., Toga, A. W., & Thompson, P. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.015 · Cited by 128
Self-citationEvidence‐based Dementia Practice
Qizilbash, N. (2003) · Wiley eBooks · doi:10.1002/9780470752340 · Cited by 118
Hippocampal shape analysis in Alzheimer’s disease: A population-based study
Scher, I., Xu, Y., Korf, E. S. C., White, L. R., Scheltens, P., Toga, A. W., Thompson, P. M., Hartley, S. W., Witter, M. P., Valentino, D. J., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.036 · Cited by 117
Self-citationLinear measures of atrophy in mild Alzheimer disease.
Frisoni, G. B., Beltramello, A., Weiss, C., Geroldi, C., Bianchetti, A., & Trabucchi, M. (1996) · PubMed Central · Cited by 116
Self-citationKloosterman, F., Witter, M. P., & van Haeften, T. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10472 · Cited by 113
Three-dimensional Patterns of Hippocampal Atrophy in Mild Cognitive Impairment
Becker, J. T. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.97 · Cited by 106
Tamamaki, N., & Nojyo, Y. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902910403 · Cited by 102
Radial width of the temporal horn: a sensitive measure in Alzheimer disease.
Frisoni, G. B., Geroldi, C., Beltramello, A., Bianchetti, A., Binetti, G. G., Bordiga, G., DeCarli, C. S., Laakso, M. P., Soininen, H. S., Testa, C., et al. (2002) · PubMed Central · Cited by 102
Self-citationThe Hippocampus and Memory of Verbal and Pictorial MaterialPreprint
Papanicolaou, A. C., Simos, P. G., Castillo, E. M., Breier, J. I., Katz, J. S., & Wright, A. A. (2002) · Learning & Memory · doi:10.1101/lm.44302 · Cited by 94
PROPELLER MRI visualizes detailed pathology of hippocampal sclerosis
Eriksson, S. H., Thom, M., Bartlett, P. A., Symms, M. R., McEvoy, A. W., Sisodiya, S. M., & Duncan, J. S. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01277.x · Cited by 64
Comparison of Hippocampal Volumetry at 1.5 Tesla and at 3 Tesla
Briellmann, R. S., Syngeniotis, A., & Jackson, G. D. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.0420081021.x · Cited by 61
Morphology of the inner structure of the hippocampal formation in Alzheimer disease.
Adachi, M., Kawakatsu, S., Hosoya, T., Otani, K., Honma, T., Shibata, A., & Sugai, Y. (2003) · PubMed Central · Cited by 54
MEDICAL AND SURGICAL INTELLIGENCE.
NA (1823) · The Lancet · doi:10.1016/s0140-6736(01)18841-0 · Cited by 29
Ageing of the human entorhinal cortex and subicular complex.
Trillo, L., & Lm, G. (1992) · PubMed · Cited by 14
Research works printed but not linked: 4
- Frisoni, 1996, American Journal of Neuroradiology, 17, 913
- Frisoni, 2002, American Journal of Neuroradiology, 23, 35
- 1996, Medline Rows With NULL issns Will Point To This, 3, 19
- Trillo, 1992, Histology and histopathology, 7, 17
Cited by
Sorted by citations
Iglesias, J. E., Augustinack, J. C., Nguyen, K., Player, C. M., Player, A., Wright, M., Roy, N., Frosch, M. P., McKee, A. C., Wald, L. L., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.042 · Cited by 1,267
Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972
Brain atrophy in Alzheimer’s Disease and aging
Pini, L., Pievani, M., Bocchetta, M., Altomare, D., Bosco, P., Cavedo, E., Galluzzi, S., Marizzoni, M., & Frisoni, G. B. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.01.002 · Cited by 836
Self-citationEwers, M., Walsh, C., Trojanowski, J. Q., Shaw, L. M. J., Petersen, R. C., Jack, C. R., Feldman, H., Bokde, A. L. W., Alexander, G. E., Scheltens, P., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.019 · Cited by 421
Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease
de Florès, R., Joie, R. L., & Chételat, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.033 · Cited by 387
Metadata
- Authors
- Frisoni, G. B., Ganzola, R., Canu, E., Rub, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., & Thompson, P. M.
- Affiliations
- University of California, Los Angeles (US)
- Goethe University Frankfurt (DE)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11-06
- Volume
- 131
- Issue
- 12
- Pages
- 3266-3276
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2090537659
- Cited by
- 256
- References
- 53
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 13 · 2020: 24 · 2019: 19 · 2018: 10 · 2017: 17 · 2016: 14 · 2015: 27 · 2014: 25 · 2013: 15 · 2012: 12
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, normal aging, hippocampal atrophy, hippocampal subfields, CA1, presubiculum, hippocampal volume, T1-weighted imaging, 3T MRI
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain Mapping, Female, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales
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