Cited by 236Functional Brain Connectivity StudiesEpilepsy research and treatmentNeural dynamics and brain function

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Global and regional functional connectivity maps of neural oscillations in focal epilepsy

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Englot, Dario J., Hinkley, Leighton B., Kort, Naomi S., Imber, Brandon S., Mizuiri, Danielle, Honma, Susanne M., Findlay, Anne M., Garrett, Coleman, Cheung, Paige L., Mantle, Mary, Tarapore, Phiroz E., Knowlton, Robert C., Chang, Edward F., Kirsch, Heidi E., Nagarajan, Srikantan S.·2015·Brain

DOI 10.1093/brain/awv130PMC PMC4840946

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Abstract

Intractable focal epilepsy is a devastating disorder with profound effects on cognition and quality of life. Epilepsy surgery can lead to seizure freedom in patients with focal epilepsy; however, sometimes it fails due to an incomplete delineation of the epileptogenic zone. Brain networks in epilepsy can be studied with resting-state functional connectivity analysis, yet previous investigations using functional magnetic resonance imaging or electrocorticography have produced inconsistent results. Magnetoencephalography allows non-invasive whole-brain recordings, and can be used to study both long-range network disturbances in focal epilepsy and regional connectivity at the epileptogenic zone. In magnetoencephalography recordings from presurgical epilepsy patients, we examined: (i) global functional connectivity maps in patients versus controls; and (ii) regional functional connectivity maps at the region of resection, compared to the homotopic non-epileptogenic region in the contralateral hemisphere. Sixty-one patients were studied, including 30 with mesial temporal lobe epilepsy and 31 with focal neocortical epilepsy. Compared with a group of 31 controls, patients with epilepsy had decreased resting-state functional connectivity in widespread regions, including perisylvian, posterior temporo-parietal, and orbitofrontal cortices (P < 0.01, t-test). Decreased mean global connectivity was related to longer duration of epilepsy and higher frequency of consciousness-impairing seizures (P < 0.01, linear regression). Furthermore, patients with increased regional connectivity within the resection site (n = 24) were more likely to achieve seizure postoperative seizure freedom (87.5% with Engel I outcome) than those with neutral (n = 15, 64.3% seizure free) or decreased (n = 23, 47.8% seizure free) regional connectivity (P < 0.02, chi-square). Widespread global decreases in functional connectivity are observed in patients with focal epilepsy, and may reflect deleterious long-term effects of recurrent seizures. Furthermore, enhanced regional functional connectivity at the area of resection may help predict seizure outcome and aid surgical planning.

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Authors: Englot, D. J., Hinkley, L. B., Kort, N. S., Imber, B. S., Mizuiri, D., Honma, S. M., Findlay, A. M., Garrett, C., Cheung, P. L., Mantle, M., Tarapore, P. E., Knowlton, R. C., Chang, E. F., Kirsch, H. E., & Nagarajan, S. S.
Affiliations: University of California, San Francisco (US)
ORCID: Englot, Dario J.
Hinkley, Leighton B.
Imber, Brandon S.
Mizuiri, Danielle
Findlay, Anne M.
Tarapore, Phiroz E.
Knowlton, Robert C.
Chang, Edward F.
Kirsch, Heidi E.
Nagarajan, Srikantan S.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2015-05-16
Volume: 138
Issue: 8
Pages: 2249-2262
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awv130
PMC: PMC4840946
OpenAlex: W2133288538
Cited by: 236
References: 66
Citations by year: 2026: 11 · 2025: 15 · 2024: 23 · 2023: 23 · 2022: 23 · 2021: 23 · 2020: 29 · 2019: 22 · 2018: 23 · 2017: 21 · 2016: 18 · 2015: 2
FWCI: 12.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Brain (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (1f32ns086353-01a1)
National Institute on Deafness and Other Communication Disorders (R01DC013979)
National Institute of Neurological Disorders and Stroke (R21 NS76171, F32-NS086353, R21NS076171)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: focal epilepsy, resting-state functional connectivity, neural oscillations, epileptogenic zone, epilepsy surgery, mesial temporal lobe epilepsy, seizure outcome prediction, Engel classification, seizure duration, magnetoencephalography, surgical planning
MeSH terms: Adult, Brain Mapping, Cerebral Cortex, Electrodes, Implanted, Epilepsies, Partial, Female, Humans, Magnetic Resonance Imaging, Male, Magnetoencephalography, Treatment Outcome

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Global and regional functional connectivity maps of neural oscillations in focal epilepsy

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