CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

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Items 101–200 of 227

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8. Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer’s Disease
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14. Nutraceuticals and physical activity: Their role on oxysterols-mediated neurodegeneration
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16. Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma
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17. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors
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20. The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis
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22. Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke
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25. Lipoprotein Metabolism, Protein Aggregation, and Alzheimer’s Disease: A Literature Review
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26. Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes
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27. Dietary High Cholesterol and Trace Metals in the Drinking Water Increase Levels of ABCA1 in the Rabbit Hippocampus and Temporal Cortex
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28. The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression
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29. Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in Mice
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30. Transcriptome-wide association study reveals cholesterol metabolism gene Lpl is a key regulator of cognitive dysfunction
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31. Effect of Hydroalcoholic Ginger Extract on Brain HMG-CoA Reductase and CYP46A1 Levels in Streptozotocin-induced Diabetic Rats.
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32. Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes
    Donghui Yan, Bowen Hu, Burcu F. Darst, Shubhabrata Mukherjee, Brian W. Kunkle, Yuetiva K. Deming, Logan C. Dumitrescu, Yunling Wang, Adam Christian Naj, Amanda B Kuzma et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
33. Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz
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34. Development of a Novel 18F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography
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37. Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers
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38. Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-D-Aspartate Receptors, Long-Term Potentiation, and Learning
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39. Cholesterol metabolism and oxysterols in neurodegenerative disorders: Spotlight on Alzheimer's disease
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40. Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma
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41. Cytochrome P450 Mining for Bufadienolide Diversification
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42. The importance of choosing the appropriate cholesterol quantification method: enzymatic assay versus gas chromatography
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43. Current advances in combining stem cell and gene therapy for neurodegenerative diseases
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44. Relationship between the hippocampal expression of selected cytochrome P450 isoforms and the animal performance in the hippocampus-dependent learning task
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45. Small molecule biomarkers in Alzheimer’s disease
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46. Increased protein expression of ABCA1, HMG-CoA reductase, and CYP46A1 induced by garlic and allicin in the brain mouse and astrocytes-isolated from C57BL/6J.
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47. Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axis
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48. Treatment with efavirenz extends survival in a Creutzfeldt-Jakob disease model by regulating brain cholesterol metabolism
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49. Cholesterol and its reciprocal association with prion infection
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50. Characterization of Dicaffeoylspermidine Derivatives from Wolfberry as Potent and Selective Inhibitors of Human Cytochrome P450 46A1 In vitro
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51. What does the research say about androgen use and cerebrovascular events?
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52. miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer’s Disease
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53. Molecular mechanisms of exercise-induced improvements in Alzheimer’s disease: a focus on lipid homeostasis
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54. Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort
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55. Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity
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56. Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems
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57. Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer’s Disease Model
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58. A study on cholesterol-cholesteryl ester metabolic homeostasis and drug intervention in hyperlipidemic hamsters using UHPLC-MS/MS
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59. Cholesterol and Fat Metabolism in Alzheimer’s Disease
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60. Expression levels of 39 Cyp mRNAs in the mouse brain and neuroblastoma cell lines, C-1300N18 and NB2a – strong expression of Cyp1b1
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61. Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging
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65. Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse
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