CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

Apoptosis: A Review of Programmed Cell Death

Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853 · see citing works

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,035 · see citing works

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677 · see citing works

Amyloid Precursor Protein Trafficking, Processing, and Function

Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

Cholesterol metabolism in the brain

Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906 · see citing works

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 886 · see citing works

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.

Cataldo, A., Peterhoff, C., Troncoso, J., Gómez-Isla, T., Hyman, B., & Nixon, R. (2000) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64538-5 · Cited by 789 · see citing works

ZnT-3, a putative transporter of zinc into synaptic vesicles

Palmiter, R. D., Cole, T. B., Quaife, C. J., & Findley, S. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14934 · Cited by 708 · see citing works

Lipid rafts: heterogeneity on the high seas

PIKE, L. J. (2004) · Biochemical Journal · doi:10.1042/bj20031672 · Cited by 705 · see citing works

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

Hetz, C., & Mollereau, B. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3689 · Cited by 684 · see citing works

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, A., Diczfalusy, U., & Björkhem, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9799 · Cited by 682 · see citing works

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Lund, E. G., Guileyardo, J. M., & Russell, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7238 · Cited by 668 · see citing works

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16452 · Cited by 600 · see citing works

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemuller, A. J. M., Eikelenboom, P., & Scheper, W. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080814 · Cited by 600 · see citing works

Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

Casserly, I., & Topol, E. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15900-x · Cited by 560 · see citing works

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Björkhem, I., Lütjohann, D., Diczfalusy, U., Ståhle, L., Ahlborg, G., & Wahren, J. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32188-x · Cited by 538 · see citing works

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

Infante, R. E., Wang, M. L., Radhakrishnan, A., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807328105 · Cited by 485 · see citing works

ABCA1: the gatekeeper for eliminating excess tissue cholesterol

Oram, J. F., & Lawn, R. M. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31566-2 · Cited by 481 · see citing works

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421 · see citing works

Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)

Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382 · see citing works

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 381 · see citing works

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

Mueller, S. G., Schuff, N., Yaffe, K., Madison, C., Miller, B., & Weiner, M. W. (2010) · Human Brain Mapping · doi:10.1002/hbm.20934 · Cited by 361 · see citing works

A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus

Ishizuka, N., Cowan, W. M., & Amaral, D. G. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903620103 · Cited by 350 · see citing works

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

Vance, J. E. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010124 · Cited by 342 · see citing works

Correlation between rates of brain atrophy and cognitive decline in AD

Fox, N. C., Scahill, R. I., Crum, W. R., & Rossor, M. N. (1999) · Neurology · doi:10.1212/wnl.52.8.1687 · Cited by 338 · see citing works

Cholesterol 24-Hydroxylase: an enzyme of cholesterol turnover in the brain

Russell, D. W., Halford, R. W., Ramirez, D. M. O., Shah, R., & Kotti, T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103859 · Cited by 317 · see citing works

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

Mattson, M. P., Partin, J. V., & Begley, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00763-x · Cited by 260 · see citing works

Molecular Profiling of Inflammatory Breast Cancer

Bièche, I., Lerebours, F., Tozlu, S., Espié, M., Marty, M. E., & Lidereau, R. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0306 · Cited by 245 · see citing works

Toxicity of Amyloid β Peptide: Tales of Calcium, Mitochondria, and Oxidative Stress

Canevari, L., Abramov, A. Y., & Duchen, M. R. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014834.06405.af · Cited by 221 · see citing works

Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments

Vetrivel, K. S., & Thinakaran, G. (2006) · Neurology · doi:10.1212/01.wnl.0000192107.17175.39 · Cited by 217 · see citing works

Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice

Bondolfi, L., Calhoun, M., Ermini, F., Kuhn, H. G., Wiederhold, K.-H., Walker, L., Staufenbiel, M., & Jucker, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00515.2002 · Cited by 213 · see citing works

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Bogdanović, N., Brétillon, L., Lund, E. G., Diczfalusy, U., Lannfelt, L., Winblad, B. G., Russell, D. W., & Björkhem, I. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02277-7 · Cited by 213 · see citing works

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport

Cheruku, S. R., Xu, Z., Dutia, R., Lobel, P., & Storch, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602765200 · Cited by 204 · see citing works

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

Hudry, E., Dam, D. V., Kulik, W., Deyn, P. P. D., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougneres, P. F., Aubourg, P. R., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.175 · Cited by 196 · see citing works

Local cholesterol increase triggers amyloid precursor protein‐Bacel clustering in lipid rafts and rapid endocytosis

Marquer, C., Devauges, V., Cossec, J., Liot, G., Lécart, S., Saudou, F., Duyckaerts, C. J., Lévêque‐Fort, S., & Potier, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-168633 · Cited by 188 · see citing works

Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model

Sturchler, C., & Staufenbiel, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06915.x · Cited by 168 · see citing works

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Xie, C., Lund, E. G., Turley, S. D., Russell, D. W., & Dietschy, J. M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300164-jlr200 · Cited by 159 · see citing works

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

Mondragón‐Rodríguez, S., Perry, G. L., Zhu, X., Moreira, P. I., Acevedo, M., & Williams, S. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/940603 · Cited by 155 · see citing works

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

Lazar, A. N., Bich, C., Panchal, M., Desbenoît, N., Petit, V. W., Touboul, D., Dauphinot, L., Marquer, C., Laprévôte, O., Brunelle, A., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1041-1 · Cited by 141 · see citing works

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C

Asselah, T., Bièche, I., Mansouri, A., Laurendeau, I., Cazals-Hatem, D. L., Feldmann, G., Bédossa, P., Paradis, V., Martinot-Peignoux, M., Lebrec, D., et al. (2010) · The Journal of Pathology · doi:10.1002/path.2703 · Cited by 127 · see citing works

Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer's disease

Faure, A., Verret, L., Bozon, B., El Tannir El Tayara, N., Ly, M., Kober, F., Dhenain, M., Rampon, C., & Delatour, B. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.009 · Cited by 112 · see citing works

Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease

Leal, S. L., & Yassa, M. A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.006 · Cited by 110 · see citing works

Carotid Atherosclerosis and Prospective Risk of Dementia

Wendell, C. R., Waldstein, S. R., Ferrucci, L., O’Brien, R., Strait, J. B., & Zonderman, A. B. (2012) · Stroke · doi:10.1161/strokeaha.112.672527 · Cited by 109 · see citing works

Cholesterol synthesis rate in human hippocampus declines with aging

Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.034 · Cited by 107 · see citing works

Uptake of lipoproteins for axonal growth of sympathetic neurons

Posse de Chaves, E. I., Vance, D. E., Campenot, R. B., Kiss, R. S., & Vance, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.26.19883 · Cited by 105 · see citing works

Prevention of interferon-stimulated gene expression using microRNA-designed hairpins

Bauer, M., Kinkl, N., Meixner, A., Kremmer, E., Riemenschneider, M. J., Förstl, H., Gasser, T., & Ueffing, M. (2008) · Gene Therapy · doi:10.1038/gt.2008.123 · Cited by 96 · see citing works

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

Cossec, J., Simon, A., Marquer, C., Moldrich, R. X., Leterrier, C., Rossier, J., Duyckaerts, C. J., Lenkei, Z., & Potier, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.010 · Cited by 90 · see citing works

Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy.

Sevin, C., Benraiss, A., Dam, D. V., Bonnin, D., Nagels, G., Vérot, L., Laurendeau, I., Vidaud, M., Gieselmann, V., Vanier, M., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi425 · Cited by 87 · see citing works

The Role of Carotid Atherosclerosis in Alzheimer's Disease Progression

Silvestrini, M., Viticchi, G., Falsetti, L., Balucani, C., Vernieri, F., Cerqua, R., Luzzi, S., Bartolini, M., & Provinciali, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101968 · Cited by 85 · see citing works

Accelerated Human Mutant Tau Aggregation by Knocking Out Murine Tau in a Transgenic Mouse Model

Ando, K., Leroy, K., Héraud, C., Yilmaz, Z., Authelet, M., Suain, V., Decker, R. D., & Brion, J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.034 · Cited by 80 · see citing works

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

Shafaati, M., Olin, M., Båvner, A., Pettersson, H. I., Rozell, B., Meaney, S., Parini, P., & Björkhem, I. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02389.x · Cited by 66 · see citing works

Impact of cholesterol level upon APP and BACE proximity and APP cleavage

Arnim, C. A. F. V., von Einem, B., Weber, P., Wagner, M., Schwanzar, D., Spoelgen, R., Strauß, W. S. L., & Schneckenburger, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.047 · Cited by 61 · see citing works

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200216452 · Cited by 48 · see citing works

Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: application to a neuroinflammation rat model

Ayciriex, S., Regazzetti, A., Gaudin, M., Prost, É., Dargère, D., Massicot, F., Auzeil, N., & Laprévôte, O. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6396-6 · Cited by 26 · see citing works

Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol

Lütjohann, D., Björkhem, I., Locatelli, S., Dame, C., Schmolling, J. C., von Bergmann, K., & Fahnenstich, H. (2001) · Acta Paediatrica · doi:10.1111/j.1651-2227.2001.tb02429.x · Cited by 20 · see citing works

The distribution of filipin‐sterol complexes in photoreceptor synaptic membranes

Cooper, N. G. F., & McLaughlin, B. J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300311 · Cited by 15 · see citing works

Elevated Aβ42 in Aged, Non-demented Individuals with Cerebral Atherosclerosis

Sadleir, K. R., Bennett, D. A., Schneider, J. A., & Vassar, R. J. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990152 · Cited by 15 · see citing works

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.12.013 · Cited by 350 · see citing works

Oxysterols: From cholesterol metabolites to key mediators

Mutemberezi, V., Guillemot‐Legris, O., & Muccioli, G. G. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.002 · Cited by 336 · see citing works

Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Song, Y., Liu, J., Zhao, K. Z., Gao, L., & Zhao, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.001 · Cited by 325 · see citing works

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

Loera‐Valencia, R., Goikolea, J., Parrado‐Fernández, C., Merino‐Serrais, P., & Maioli, S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.003 · Cited by 228 · see citing works

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Boussicault, L., Alves, S., Lamazière, A., Planques, A., Heck, N., Moumné, L., Després, G., Bolte, S., Hu, A., Pagès, C., et al. (2016) · Brain · doi:10.1093/brain/awv384 · Cited by 198 · see citing works

Brain cell type-specific cholesterol metabolism and implications for learning and memory

Li, D., Zhang, J., & Liu, Q. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.01.002 · Cited by 163 · see citing works

Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine

Eid, A., Mhatre, I., & Richardson, J. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.005 · Cited by 164 · see citing works

Abnormal brain cholesterol homeostasis in Alzheimer’s disease-a targeted metabolomic and transcriptomic study

Varma, V. R., Büşra Lüleci, H., Oommen, A. M., Varma, S., Blackshear, C. T., Griswold, M. E., An, Y., Roberts, J. A., O’Brien, R., Pletnikova, O., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00064-9 · Cited by 153 · see citing works

Current and emerging avenues for Alzheimer's disease drug targets

Loera‐Valencia, R., Cedazo-Mı́nguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 139 · see citing works

Estrogen receptors and the aging brain

Maioli, S., Leander, K., Nilsson, P., & Nalvarte, I. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200162 · Cited by 114 · see citing works

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity

Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134 · see citing works

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

Barbero-Camps, E., Roca-Agujetas, V., Bartolessis, I., de Dios, C., Fernández-Checa, J. C., Marí, M., Morales, A., Hartmann, T., & Colell, A. (2018) · Autophagy · doi:10.1080/15548627.2018.1438807 · Cited by 125 · see citing works

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

Montesinos, J., Pera, M., Larrea, D., Guardia-Laguarta, C., Agrawal, R., Velasco, K., Yun, T. D., Stavrovskaya, I., Xu, Y., Koo, S.-Y.-O., et al. (2020) · EMBO Journal · doi:10.15252/embj.2019103791 · Cited by 102 · see citing works

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

Kacher, R., Lamazière, A., Heck, N., Kappès, V., Mounier, C., Després, G., Dembitskaya, Y., Perrin, E., Christaller, W., Nair, S. S., et al. (2019) · Brain · doi:10.1093/brain/awz174 · Cited by 115 · see citing works

Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human

Jee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y.-S. (2020) · Nutrients · doi:10.3390/nu12103080 · Cited by 111 · see citing works

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

Mast, N., Saadane, A., Valencia‐Olvera, A. C., Constans, J., Maxfield, E., Arakawa, H., Li, Y., Landreth, G. E., & Pikuleva, I. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.026 · Cited by 108 · see citing works

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.

Jeong, W., Lee, H. G., Cho, S., & Seo, J. (2019) · PubMed Central · doi:10.14348/molcells.2019.0200 · Cited by 104 · see citing works

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

Lee, S.-I., Jeong, W., Lim, H., Cho, S., Lee, H., Jang, Y., Cho, J., Bae, S., Lin, Y.-T., Tsai, L.-H., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.07.017 · Cited by 105 · see citing works

Cholesterol metabolism: physiological regulation and diseases

Guo, J., Chen, S., Zhang, Y., Liu, J., Jiang, L., Hu, L., Yao, K., Yu, Y., & Chen, X. (2024) · MedComm · doi:10.1002/mco2.476 · Cited by 103 · see citing works

Oxysterol research: a brief review

Griffiths, W. J., & Wang, Y. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180135 · Cited by 103 · see citing works

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

Petrov, A. M., & Pikuleva, I. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00731-6 · Cited by 101 · see citing works

Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer’s Disease: A Meta-Analysis

Wang, H.-L., Wang, Y.-Y., Liu, X., Kuo, S., Liu, N., Song, Q.-Y., & Wang, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150734 · Cited by 99 · see citing works

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models

Zhao, Y., Hu, D., Wang, R., Sun, X., Ropelewski, P., Hubler, Z. M. L., Lundberg, K. C., Wang, Q., Adams, D., Xu, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28769-9 · Cited by 97 · see citing works

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s disease

Rudajev, V., & Novotný, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937056 · Cited by 94 · see citing works

7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity

Véjux, A., Abed-Vieillard, D., Hajji, K., Zarrouk, A., Mackrill, J. J., Ghosh, S., Nury, T., Yammine, A., Zaibi, M. S., Mihoubi, W., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113648 · Cited by 92 · see citing works

Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword

Fernández-Pérez, E. J., Sepúlveda, F. J., Peters, C., Bascuñán, D., Riffo-Lepe, N., González-Sanmiguel, J., Sánchez, S. A., Peoples, R. W., Vicente, B., & Aguayo, L. G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00226 · Cited by 90 · see citing works

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

Nóbrega, C., Mendonça, L. S., Marcelo, A., Lamazière, A., Tomé, S. O., Després, G., Matos, C. A., Mechmet, F., Langui, D., den Dunnen, W. F. A., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02019-7 · Cited by 83 · see citing works

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases

Sodero, A. O. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15228 · Cited by 84 · see citing works

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

Petrov, A. M., Lam, M., Mast, N., Moon, J., Li, Y., Maxfield, E., & Pikuleva, I. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00737-0 · Cited by 86 · see citing works

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

Pikuleva, I. A., & Cartier, N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.696778 · Cited by 81 · see citing works

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease

Gamba, P., Giannelli, S., Staurenghi, E., Testa, G., Sottero, B., Biasi, F., Poli, G., & Leonarduzzi, G. (2021) · Antioxidants · doi:10.3390/antiox10050740 · Cited by 76 · see citing works

Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives

Wu, J., Guan, X., Dai, Z., He, R.-J., Ding, X., Yang, L., & Ge, G. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213600 · Cited by 76 · see citing works

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Nishi, T., Kondo, S., Miyamoto, M., Watanabe, S., Hasegawa, S., Kondo, S., Yano, J. K., Watanabe, E., Ishi, T., Yoshikawa, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74036-6 · Cited by 76 · see citing works

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

Moutinho, M., Nunes, M. J., & Rodrigues, E. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.011 · Cited by 72 · see citing works

A Review of Oxidative Stress Products and Related Genes in Early Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., Bansal, R., & Broersen, K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210497 · Cited by 73 · see citing works

Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice

Paul, R. K., & Borah, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17911-z · Cited by 67 · see citing works

Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders

Cheon, S. Y. (2023) · Experimental Neurobiology · doi:10.5607/en23010 · Cited by 67 · see citing works

Pathophysiological implications of neurovascular P450 in brain disorders

Ghosh, C., Hossain, M. K., Solanki, J., Dadas, A., Marchi, N., & Janigro, D. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.004 · Cited by 64 · see citing works

Role of the Lipid Membrane and Membrane Proteins in Tau Pathology

Bok, E., Leem, E., Lee, B.-R., Lee, J. M., Yoo, C. J., Lee, E. M., & Kim, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653815 · Cited by 61 · see citing works

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Onyango, I. G. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.224362 · Cited by 61 · see citing works

Targeting Alzheimer's disease with gene and cell therapies

Loera‐Valencia, R., Piras, A., Ismail, M.-A.-M., Manchanda, S., Eyjolfsdottir, H., Saido, T. C., Johansson, J., Eriksdotter, M., Winblad, B. G., & Nilsson, P. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12759 · Cited by 57 · see citing works

A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model

Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58 · see citing works

Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development

Ahmed, H., Wang, Y., Griffiths, W. J., Levey, A. I., Pikuleva, I. A., Liang, S. H., & Haider, A. (2024) · Brain · doi:10.1093/brain/awae028 · Cited by 57 · see citing works

The lysosomal storage disease continuum with ageing-related neurodegenerative disease

Lloyd‐Evans, E., & Haslett, L. J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.07.005 · Cited by 57 · see citing works

Central nervous system cholesterol metabolism in health and disease

Ho, W. Y., Hartmann, H., & Ling, S. (2022) · IUBMB Life · doi:10.1002/iub.2662 · Cited by 55 · see citing works

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

Anderson, K. W., Mast, N., Hudgens, J. W., Lin, J. B., Turko, I. V., & Pikuleva, I. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.723577 · Cited by 55 · see citing works

Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases

Navarro‐Mabarak, C., Camacho‐Carranza, R., & Espinosa-Aguirre, J. J. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1439502 · Cited by 53 · see citing works

Increased Levels of 27‐Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats

Zhang, X., Lv, C., An, Y., Liu, Q., Rong, H., Tao, L., Wang, Y., Wang, Y., & Xiao, R. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700531 · Cited by 52 · see citing works

The relationship between cholesterol level and Alzheimer’s disease-associated APP proteolysis/Aβ metabolism

Wang, C.-Q., Shou, Y., Pan, J., Du, Y., Liu, C.-Q., & Wang, H. (2018) · Nutritional neuroscience · doi:10.1080/1028415x.2017.1416942 · Cited by 46 · see citing works

Regular Intake of Pistachio Mitigates the Deleterious Effects of a High Fat-Diet in the Brain of Obese Mice

Nuzzo, D., Galizzi, G., Amato, A., Terzo, S., Picone, P., Cristaldi, L., Mulè, F., & Carlo, M. D. (2020) · Antioxidants · doi:10.3390/antiox9040317 · Cited by 50 · see citing works

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)

Koike, T., Yoshikawa, M., Ando, H. K., Farnaby, W., Nishi, T., Watanabe, E., Yano, J. K., Miyamoto, M., Kondo, S., Ishii, T., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00864 · Cited by 48 · see citing works

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

Theofilopoulos, S., de Oliveira, W. A. A., Yang, S., Yutuc, E., Saeed, A., Abdel‐Khalik, J., Ullgren, A., Cedazo-Mı́nguez, Á., Björkhem, I., Wang, Y., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005639 · Cited by 46 · see citing works

Gene Therapy Strategies for Alzheimer's Disease: An Overview

Alves, S., Fol, R., & Cartier, N. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.017 · Cited by 45 · see citing works

Mechanisms of Mitochondrial Malfunction in Alzheimer’s Disease: New Therapeutic Hope

Nabi, S. U., Khan, A., Siddiqui, E. M., Rehman, M. U., Alshahrani, S., Arafah, A. M., Mehan, S., Alsaffar, R. M., Alexiou, A. T., & Shen, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4759963 · Cited by 48 · see citing works

Assessment of cholesterol homeostasis in the living human brain

Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S. K., Mast, N., Yutuc, E., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.adc9967 · Cited by 44 · see citing works

The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders

Haduch, A., & Daniel, W. A. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1554674 · Cited by 45 · see citing works

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Rudajev, V., & Novotný, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01127-y · Cited by 47 · see citing works

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis

Borràs, C., Mercer, A., Sirisi, S., Alcolea, D. A., Escolá‐Gil, J. C., Blanco‐Vaca, F., & Tondo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169356 · Cited by 41 · see citing works

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

Mast, N., Anderson, K. W., Johnson, K. M., Phan, T. T. N., Guengerich, F. P., & Pikuleva, I. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.794909 · Cited by 42 · see citing works

Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes

Azizidoost, S., Babaahmadi‐Rezaei, H., Nazeri, Z., Cheraghzadeh, M., & Kheirollah, A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159069 · Cited by 39 · see citing works

Statins and the brain: New perspective for old drugs

Ling, Q., & Tejada-Simon, M. V. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.013 · Cited by 38 · see citing works

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Ali, T., Hannaoui, S., Nemani, S. K., Tahir, W., Zemlyankina, I., Cherry, P., Shim, S. Y., Sim, V. L., Schaetzl, H. M., & Gilch, S. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01162-1 · Cited by 38 · see citing works

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Ayciriex, S., Djelti, F., Alves, S., Regazzetti, A., Gaudin, M., Varin, J., Langui, D., Bièche, I., Hudry, E., Dargère, D., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00211 · Cited by 37 · see citing works

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

Moutinho, M., Nunes, M. J., Correia, J. C., Gama, M. J., Castro‐Caldas, M., Cedazo-Mı́nguez, Á., Rodrigues, C. M. P., Björkhem, I., Ruas, J. L., & Rodrigues, E. (2016) · Scientific Reports · doi:10.1038/srep30928 · Cited by 36 · see citing works

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

Mast, N., Lin, J. B., Anderson, K. W., Björkhem, I., & Pikuleva, I. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187168 · Cited by 35 · see citing works

Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes

Petrov, A. M., Mast, N., Li, Y., Denker, J. A., & Pikuleva, I. A. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa043 · Cited by 34 · see citing works

Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

Saint‐Pol, J., & Gosselet, F. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.04.017 · Cited by 33 · see citing works

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

Mast, N., Verwilst, P., Wilkey, C. J., Guengerich, F. P., & Pikuleva, I. A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01383 · Cited by 33 · see citing works

The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment

Petrov, A. M., Mast, N., Li, Y., & Pikuleva, I. A. (2019) · The FASEB Journal · doi:10.1096/fj.201900092r · Cited by 31 · see citing works

Ethanol, neurosteroids and cellular stress responses: Impact on central nervous system toxicity, inflammation and autophagy

Fujii, C., Zorumski, C. F., & Izumi, Y. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.026 · Cited by 30 · see citing works

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice

Latorre‐Leal, M., Rodriguez‐Rodriguez, P., Franchini, L., Nikolidakis, O., Daniilidou, M., Delac, L., Varshney, M., Arroyo‐García, L. E., Eroli, F., Winblad, B. G., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj1354 · Cited by 30 · see citing works

Neural Stem Cells in the Treatment of Alzheimer’s Disease: Current Status, Challenges, and Future Prospects

Chen, X., Jiang, S., Wang, R., Bao, X., & Li, Y. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220721 · Cited by 31 · see citing works

White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

Sharp, F. R., DeCarli, C. S., Jin, L., & Zhan, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1096206 · Cited by 30 · see citing works

Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection

Almeida, M. C., Eger, S. J., He, C., Audouard, M., Nikitina, A. A., Glasauer, S. M. K., Han, D., Mejía‐Cupajita, B., Acosta‐Uribe, J., Villalba‐Moreno, N. D., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.02.009 · Cited by 28 · see citing works

Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation

Durairaj, P., & Liu, Z. L. (2025) · Journal of Xenobiotics · doi:10.3390/jox15020044 · Cited by 28 · see citing works

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

Popiolek, M., Izumi, Y., Hopper, A. T., Dai, J., Miller, S., Shu, H., Zorumski, C. F., & Mennerick, S. J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.568641 · Cited by 28 · see citing works

27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells

Wang, Y., Zhang, X., Wang, T., Liu, W., Wang, L., Hao, L., Ju, M., & Xiao, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.580599 · Cited by 28 · see citing works

Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline

Jena, P. K., Setayesh, T., Sheng, L., Lucente, J. D., Jin, L. W., & Wan, Y. Y. (2022) · Cells · doi:10.3390/cells11030504 · Cited by 26 · see citing works

Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, V. K., Lal, N., Awasthi, S. K., & Kalani, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103547 · Cited by 28 · see citing works

Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline

Anderson, T., Sharma, S. K., Kelberman, M. A., Ware, C. B., Guo, N., Qin, Z. S., Weinshenker, D., & Parent, M. B. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15900 · Cited by 26 · see citing works

The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson’s disease

Dai, L., Wang, J., Meng, L., Zhang, X., Xiao, T., Deng, M., Chen, G., Xiong, J., Ke, W., Hong, Z., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3002974 · Cited by 26 · see citing works

The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

Vuu, Y. M., Shahib, A. K., & Rastegar, M. (2023) · Pharmaceuticals · doi:10.3390/ph16070914 · Cited by 29 · see citing works

The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms

Alavi, M. S., Karimi, G., Ghanimi, H. A., & Roohbakhsh, A. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175726 · Cited by 25 · see citing works

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus

Romano, S., Mitro, N., Diviccaro, S., Spezzano, R., Audano, M., García‐Segura, L. M., Caruso, D., & Melcangi, R. C. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.11.019 · Cited by 25 · see citing works

Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances

Sheng, Y., Yang, H., Wu, T., Zhu, L., Liu, L., & Liu, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.650027 · Cited by 25 · see citing works

Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease

Onyango, I. G., Bennett, J. P., & Stokin, G. B. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211208125855 · Cited by 21 · see citing works

Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases

Zhan, N., Wang, B., Martens, N., Liu, Y., Zhao, S., Voortman, G. J., van Rooij, J., Leijten, F. P. J., Vanmierlo, T., Kuipers, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021290 · Cited by 22 · see citing works

Disturbances of brain cholesterol metabolism: A new excitotoxic process associated with status epilepticus

Hanin, A., Baudin, P., Demeret, S., Roussel, D., Lecas, S., Teyssou, E., Damiano, M. G., Luís, D., Lambrecq, V., Frazzini, V., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105346 · Cited by 22 · see citing works

Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia

Sun, Z., Zhao, L., Bo, Q., Mao, Z., He, Y., Jiang, T., Li, Y., Wang, C., & Li, R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711734 · Cited by 20 · see citing works

Tau Spread, Apolipoprotein E, Inflammation, and More

Gonzalez, B. L., Abud, E. M., Abud, A. M., Poon, W. W., & Gylys, K. H. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.001 · Cited by 20 · see citing works

Lipid markers and related transcripts during excitotoxic neurodegeneration in kainate‐treated mice

Chali, F., Milior, G., Marty, S., Morin‐Brureau, M., Duigou, C. L., Savary, E., Blugeon, C., Jourdren, L., & Miles, R. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14375 · Cited by 20 · see citing works

Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases

Pikuleva, I. A. (2021) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2021.00013 · Cited by 19 · see citing works

Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson’s disease

Kim, J.-B., Kim, S., So, M., Kim, D., Noh, H. R., Kim, B. J., Choi, Y. R., Kim, D., Koo, H., Kim, T. Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116442 · Cited by 19 · see citing works

The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Wang, C., Zhao, F., Shen, K., Wang, W., Siedlak, S. L., Lee, H., Phelix, C. F., Perry, G., Shen, L., Tang, B., et al. (2019) · Brain Pathology · doi:10.1111/bpa.12691 · Cited by 18 · see citing works

High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis

Leclerc, D., Jelı́nek, J., Christensen, K. E., Issa, J. J., & Rozen, R. R. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108554 · Cited by 18 · see citing works

Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells

Piccarducci, R., Giacomelli, C., Bertilacchi, M. S., Benito-Martínez, A., Giorgi, N. D., Daniele, S., Signore, G., Rocchiccioli, S., Vilar, M., Marchetti, L., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166793 · Cited by 18 · see citing works

Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia

Lee, J. Y., Marian, O. C., & Don, A. (2021) · Neuromolecular medicine · doi:10.1007/s12017-021-08644-4 · Cited by 13 · see citing works

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Maioli, S., Nalvarte, I., Ankarcrona, M., Schultzberg, M., Zuloaga, K. L., Goikolea, J., Visser, P. J., Strooper, B. D., Winblad, B., Pizzo, P., et al. (2025) · Journal of Internal Medicine · doi:10.1111/joim.70036 · Cited by 18 · see citing works

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease

Nóbrega, C., Conceição, A., da Costa, R. G., Koppenol, R., Sequeira, R. L., Nunes, R., Carmo‐Silva, S., Marcelo, A., Matos, C. A., Bétuing, S., et al. (2020) · BMC Research Notes · doi:10.1186/s13104-020-05053-x · Cited by 16 · see citing works

Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects

Ghosh, S., Ghzaiel, I., Véjux, A., Meaney, S., Nag, S., Lizard, G., Tripathi, G., Naez, F., & Paul, S. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_9 · Cited by 16 · see citing works

P3‐317: Hippocampal CYP46A1 overexpression is beneficial in rodent models of Alzheimer's disease

Alves, S., Lamazière, A., Audrain, M., Braudeau, J., Fouquet, F., Aubourg, P. R., & Cartier, N. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.06.1691

O3‐06‐04: Enhanced conversion of cholesterol to 24s‐hydroxycholesterol decreases amyloid‐ß and prevents alzheimer phenotype of app23 mouse model

Cartier, N., Hudry, E., Dam, D. V., Kulik, W., Deyn, P. P. D., Delacourte, A., & Aubourg, P. R. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.469

P3‐425: AAV gene therapy with cholesterol 24‐hydroxylase improves Alzheimer's phenotype of tau mouse model

Cartier, N., Gautier, B., Burlot, M., Troquier, L., Pradier, L., Aubourg, P. R., Blum, D. L., & Buée, L. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1869

O3‐14‐03: CHOLESTEROL AND TAU PATHOLOGY: CONSEQUENCES OF AAV‐MEDIATED CHOLESTEROL‐24‐HYDROXYLASE OVEREXPRESSION IN THE THY‐TAU22 MOUSE

Braudeau, J., Burlot, M., Ayciriex, S., Varin, J., Gautier, B., Djelti, F., Dauphinot, L., Zommer, N., Caillierez, R., Pradier, L., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.349 · Cited by 1 · see citing works

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

Burlot, M., Braudeau, J., Michaelsen‐Preusse, K., Potier, B., Ayciriex, S., Varin, J., Gautier, B., Djelti, F., Audrain, M., Dauphinot, L., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv268 · Cited by 122 · see citing works