Common polygenic variation enhances risk prediction for Alzheimer’s disease

Cited by (414)

Items 101–200 of 414

  1. Nasal DNA methylation at three CpG sites predicts childhood allergic disease
    Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper‐Emil Tingskov Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Bügel, Orestes A. Carpaij et al. · 2022 · Nature Communications
  2. Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes
    Sang‐Hyuk Jung, Hang‐Rai Kim, Min Young Chun, Hyemin Jang, Minyoung Cho, Beomsu Kim, Soyeon Kim, Jee Hyang Jeong, Soo Jin Yoon, Kyung Won Park et al. · 2022 · JAMA Network Open
  3. Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years
    Hannah R. Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad T. Beyreuther, Klaus Bernhard Gerwert, Ben Schöttker, Hermann Brenner · 2023 · Alzheimer s Research & Therapy
  4. Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease
    Sultan Chaudhury, Tulsi Patel, Imelda Barber, Tamar Guetta‐Baranes, Keeley J. Brookes, Sally Chappell, James C. Turton, Rita João Guerreiro, José Brás, Dena G. Hernandez et al. · 2017 · Neurobiology of Aging
  5. Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review
    Judith Rose Harrison, Sanchita Bhatia, Zhao Xuan Tan, Anastasia Mirza-Davies, Hannah Benkert, Chantal M. W. Tax, Derek Kenton Jones · 2020 · NeuroImage Clinical
  6. Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction
    Gao, Xiaoyi Raymond, Chiariglione, Marion, Qin, Ke, Nuytemans, Karen, Scharre, Douglas W., Li, Yi-Ju, Martin, Eden R. · 2023 · Scientific Reports
  7. Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants
    Heidi Foo, Anbupalam Thalamuthu, Jiyang Jiang, Forrest C. Koch, Karen A. Mather, Wei Xiong Wen, Perminder Singh Sachdev · 2020 · Neurobiology of Aging
  8. Heritability and genetic variance of dementia with Lewy bodies
    Rita João Guerreiro, Valentina Escott‐Price, Dena G. Hernandez, Célia Kun‐Rodrigues, Owen A. Ross, Tatiana Orme, João Luís Neto, Susana Carmona, Nadia Dehghani, John D. Eicher et al. · 2019 · Neurobiology of Disease
  9. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population
    Moeen Riaz, Aamira J. Huq, Joanne L. Ryan, Suzanne Gaye Orchard, Jane M. Tiller, Jessica E. Lockery, Robyn L. Woods, Rory S Wolfe, Alan Edward Renton, Alison Goate et al. · 2021 · Aging Cell
  10. Polygenic Risk Scores in Neurodegenerative Diseases: a Review
    Laura Ibáñez, Fabiana Farias, Umber Dube, Kathie A. Mihindukulasuriya, Oscar Harari · 2019 · Current Genetic Medicine Reports
  11. Assigning function to SNPs: Considerations when interpreting genetic variation
    Tayaza Fadason, Sophie L. Farrow, Sreemol Gokuladhas, Evgeniia Golovina, Denis M. Nyaga, Justin Martin O'Sullivan, William S. Schierding · 2021 · Seminars in Cell and Developmental Biology
  12. Predictive Genetic Counseling for Neurodegenerative Diseases: Past, Present, and Future
    Jill S. Goldman · 2019 · Cold Spring Harbor Perspectives in Medicine
  13. Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA
    Salemi, Michele, Mogavero, Maria Paola, Lanza, Giuseppe, Mongioì, Laura M., Calogero, Aldo E., Ferri, Raffaele · 2022 · Cells
  14. Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention
    Kazuyuki Takata, Florent Ginhoux, Shun Shimohama · 2021 · Biochemical Pharmacology
  15. Influence of genetic and cardiometabolic risk factors in Alzheimer’s disease
    Giuseppe Pasqualetti, Tony Thayanandan, Paul Edison · 2022 · Ageing Research Reviews
  16. A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease
    Tenielle Porter, Samantha C. Burnham, Greg R. Savage, Yen Ying Lim, Paul T. Maruff, Lidija Milicic, Madeline Peretti, David J. Ames, Colin Louis Masters, Ralph Nigel Martins et al. · 2018 · Frontiers in Aging Neuroscience
  17. Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease
    Sebastian Sendel, Björn‐Hergen Laabs, Meike Kasten, Eva‐Juliane Vollstedt, Jos Steffen Becktepe, Norbert Brüggemann, André Franke, Ulrike M. Krämer, Gregor Kuhlenbäumer, Wolfgang Lieb et al. · 2021 · Genes
  18. Blood Derived Amyloid Biomarkers for Alzheimer's Disease Prevention
    Chinedu Theresa Udeh‐Momoh, Bang Zheng, Anna Matton, Gerald Novak, Miia Kivipelto, Linus Jönsson, Lefkos T. Middleton · 2021 · The Journal of Prevention of Alzheimer s Disease
  19. Genome sequencing for early-onset or atypical dementia: high diagnostic yield and frequent observation of multiple contributory alleles
    J. Nicholas Cochran, Emily McKinley, J. Nicholas Cochran, Michelle D. Amaral, Bryan A. Moyers, Brittany N. Lasseigne, David E. Gray, James M.J. Lawlor, Jeremy W. Prokop, Ethan G. Geier et al. · 2019 · Molecular Case Studies
  20. Intrinsic Capacity, Polygenic Risk Score, APOE Genotype, and Risk of Dementia
    Mengtong Sun, Qida He, Na Sun, Qiang Han, Yu Wang, Hanqing Zhao, Guoxian Li, Ze Ma, Zhaolong Feng, Tongxing Li et al. · 2024 · Neurology
  21. Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years
    Shea J. Andrews, Ranmalee Eramudugolla, Jorge Ivan Velez, Nicolas Cherbuin, Simon Easteal, Kaarin Jane Anstey · 2017 · Alzheimer s Research & Therapy
  22. Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics
    Sanjeev Sariya, Daniel Felsky, Dolly Reyes‐Dumeyer, Ricky Lali, Rafael Lantigua, Badri Narayan Vardarajan, Ivonne Z. Jiménez‐Velázquez, Jonathan L. Haines, Gerard D. Shellenberg, Margaret Ann Pericak‐Vance et al. · 2021 · Annals of Neurology
  23. Machine learning for the life-time risk prediction of Alzheimer’s disease: a systematic review
    Thomas W Rowe, Ioanna K. Katzourou, Joshua O Stevenson‐Hoare, Matthew Bracher‐Smith, Dobril K. Ivanov, Valentina Escott‐Price · 2021 · Brain Communications
  24. Branched-chain amino acids and the risks of dementia, Alzheimer’s disease, and Parkinson’s disease
    Yidong Fu, Yue Wang, Huiming Ren, Xu Guo, Liyuan Han · 2024 · Frontiers in Aging Neuroscience
  25. If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
    Lezanne Ooi, Mirella Dottori, Anthony L. Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damián Hernández, Anna Elizabeth King, Simon Maksour, Helena Targa Dias Anastacio et al. · 2020 · The Neuroscientist
  26. Towards Personalized Intervention for Alzheimer’s Disease
    Xing Peng, Peiqi Xing, Xiuhui Li, Ying Qian, Fuhai Song, Zhouxian Bai, Guangchun Han, Hongxing Lei · 2016 · Genomics Proteomics & Bioinformatics
  27. Mitonuclear interactions influence Alzheimer's disease risk
    Shea J. Andrews, Brian Fulton‐Howard, Christopher Patterson, G. Peggy McFall, Alden L. Gross, Elias K. Michaelis, Alison Goate, Russell Howard Swerdlow, Judy Pa, for the Alzheimer’s Disease Neuroimaging Initiative · 2019 · Neurobiology of Aging
  28. Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives
    Jenna Najar, Sven J. van der Lee, Erik Joas, Hanna Wetterberg, John Hardy, Rita João Guerreiro, José Brás, Margda Wærn, Silke Kern, Henrik Zetterberg et al. · 2021 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
  29. Defining functional variants associated with Alzheimer’s disease in the induced immune response
    Janet C Harwood, Ganna Leonenko, Rebecca Sims, Valentina Escott‐Price, Julie H. Williams, Peter Holmans · 2021 · Brain Communications
  30. Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease
    Byron Creese, Ryan Arathimos, Dag Aarsland, Clive G. Ballard, Helen J. Brooker, Adam Hampshire, Anne Corbett, Zahinoor Ismail · 2023 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  31. Genetic Analyses of Alzheimer’s Disease in China: Achievements and Perspectives
    Dengfeng Zhang, Min Xu, Rui Bi, Yong‐Gang Yao · 2019 · ACS Chemical Neuroscience
  32. Alzheimer's disease and related dementias among aging veterans: Examining gene‐by‐environment interactions with post‐traumatic stress disorder and traumatic brain injury
    Logue, Mark W., Miller, Mark W., Sherva, Richard, Zhang, Rui, Harrington, Kelly M., Fonda, Jennifer R., Merritt, Victoria C., Panizzon, Matthew S., Hauger, Richard L., Wolf, Erika J. et al. · 2023 · Alzheimer's & Dementia
  33. Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
    Xiaopu Zhou, Yolanda Y. T. Li, Amy K.Y. Fu, Nancy Y. Ip · 2021 · Frontiers in Neuroscience
  34. Inferring the Molecular Mechanisms of Noncoding Alzheimer’s Disease-Associated Genetic Variants
    Alexandre Amlie‐Wolf, Mitchell Tang, Jessica Way, Beth A. Dombroski, Jiang Ming, Nicholas Vrettos, Yi‐Fan Chou, Yi Zhao, Amanda B Kuzma, Elisabeth E. Mlynarski et al. · 2019 · Journal of Alzheimer s Disease
  35. Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer's Disease
    Paula Daunt, Clive G. Ballard, Byron Creese, Greg Davidson, John Hardy, Olusegun Oshota, Richard J. Pither, Alex M. Gibson · 2021 · The Journal of Prevention of Alzheimer s Disease
  36. A Non-APOE Polygenic Risk Score for Alzheimer’s Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds
    Ingmar Gr. Skoog, Silke Kern, Jenna Najar, Rita João Guerreiro, José Brás, Margda Wærn, Henrik Zetterberg, Kaj Blennow, Anna Zettergren · 2021 · The Journals of Gerontology Series A
  37. Genetics of Alzheimer’s Disease in the African American Population
    Mark W. Logue, Shoumita Dasgupta, Lindsay A. Farrer · 2023 · Journal of Clinical Medicine
  38. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach
    Timothy Vivian‐Griffiths, Emily Ann Baker, Karl Michael Schmidt, Matthew Bracher‐Smith, James Walters, Andreas Artemiou, Peter Holmans, Michael C. O’Donovan, Michael John Owen, Andrew J. Pocklington et al. · 2018 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
  39. Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals
    Hannah Louise Chandler, Richard G. Wise, Kevin Murphy, Katherine E. Tansey, David E.J. Linden, Thomas Matthew Lancaster · 2019 · Scientific Reports
  40. Genetic Stratification to Identify Risk Groups for Alzheimer’s Disease
    Riccardo Emilio Marioni, Archie I Campbell, Saskia P. Hagenaars, Réka Nagy, Carmen Amador, Caroline Hayward, David John Porteous, Peter M. Visscher, Ian J. Deary · 2017 · Journal of Alzheimer s Disease
  41. The MUC6/AP2A2 Locus and Its Relevance to Alzheimer’s Disease: A Review
    Peter T. Nelson, David W. Fardo, Yuriko Katsumata · 2020 · Journal of Neuropathology & Experimental Neurology
  42. Polygenic risk scores for genetic counseling in psychiatry: Lessons learned from other fields of medicine
    E. Eeltink, Marte Z. van der Horst, Janneke Zinkstok, Cora M. Aalfs, Jurjen Justin Luykx · 2020 · Neuroscience & Biobehavioral Reviews
  43. Functional variants identify sex-specific genes and pathways in Alzheimer’s Disease
    Thomas Bourquard, Kwanghyuk Danny Lee, Ismael Al‐Ramahi, Minh Pham, Dillon Shapiro, Yashwanth Lagisetty, Shirin Soleimani, Samantha Mota, Kevin O. Wilhelm, Maryam Samieinasab et al. · 2023 · Nature Communications
  44. Microglial dysfunction in Alzheimer's disease: Mechanisms, emerging therapies, and future directions
    Mahir Azmal, Jibon Kumar Paul, Fatema Sultana Prima, A.N.M. Shah Newaz Been Haque, Meghla Meem, Ajit Ghosh · 2025 · Experimental Neurology
  45. Neurobiological substrates underlying the effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment
    Jiayuan Xu, Qiaojun Li, Wen Qin, Mulin Jun Li, Chuanjun Zhuo, Huaigui Liu, Feng Liu, Junping Wang, Günter Schumann, Chunshui Yu · 2018 · Brain
  46. Genes, pathways and risk prediction in Alzheimer’s disease
    Hardy, John, Escott-Price, Valentina · 2019 · Human Molecular Genetics
  47. Beyond the amyloid cascade: An update of Alzheimer's disease pathophysiology
    Dominique Gouilly, Marie Rafiq, Léonor Nogueira, Anne‐Sophie Salabert, Pierre Payoux, Patrice Péran, Jérémie Pariente · 2023 · Revue Neurologique
  48. Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a “gray zone”?
    Kevin McRae‐McKee, Chinedu Theresa Udeh‐Momoh, Geraint J. Price, Sumali Bajaj, Celeste A. de Jager, David Scott, Christoforos Hadjichrysanthou, Emily McNaughton, Luc Bracoud, Sara Ahmadi‐Abhari et al. · 2019 · Alzheimer s & Dementia
  49. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers
    Brian Fulton‐Howard, Alison Goate, Robert P. Adelson, Jeremy L. Koppel, Marc L. Gordon, Nir Barzilai, Gil Atzmon, Peter Davies, Yun Freudenberg‐Hua · 2020 · Neurobiology of Aging
  50. POLARIS: Polygenic LD‐adjusted risk score approach for set‐based analysis of GWAS data
    Emily Ann Baker, Karl Michael Schmidt, Rebecca Sims, Michael C. O’Donovan, Julie H. Williams, Peter Holmans, Valentina Escott‐Price · 2018 · Genetic Epidemiology
  51. Integration of Machine Learning Methods to Dissect Genetically Imputed Transcriptomic Profiles in Alzheimer’s Disease
    Carlo Maj, Tiago Azevedo, Valentina Giansanti, Oleg Borisov, Giovanna Maria Dimitri, Simeon Spasov, Alzheimer’s Disease Neuroimaging Initiative, Píetro Lió, Ivan Merelli · 2019 · Frontiers in Genetics
  52. Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease
    Amy N. Murray, Hannah Louise Chandler, Thomas Matthew Lancaster · 2020 · Neurobiology of Aging
  53. Polygenic resilience scores capture protective genetic effects for Alzheimer’s disease
    Jiahui Hou, Jonathan Hess, Nicola J. Armstrong, Joshua C. Bis, Benjamin Grenier‐Boley, Ida Karlsson, Ganna Leonenko, Katya T. Numbers, Eleanor K. O’Brien, Alexey A. Shadrin et al. · 2022 · Translational Psychiatry
  54. Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score
    Ebenau, Jarith L., van der Lee, Sven J., Hulsman, Marc, Tesi, Niccolò, Jansen, Iris E., Verberk, Inge M.W., van Leeuwenstijn, Mardou, Teunissen, Charlotte E., Barkhof, Frederik, Prins, Niels D. et al. · 2021 · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  55. Toward attention-based learning to predict the risk of brain degeneration with multimodal medical data
    Xiaofei Sun, Weiwei Guo, Jing Shen · 2023 · Frontiers in Neuroscience
  56. Cumulative Genetic Risk and APOE ε4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort
    Bakulski, Kelly M., Vadari, Harita S., Faul, Jessica D., Heeringa, Steven G., Kardia, Sharon L.R., Langa, Kenneth M., Smith, Jennifer A., Manly, Jennifer J., Mitchell, Colter M., Benke, Kelly S. et al. · 2021 · Neurology Genetics
  57. The Role of Polygenic Score and Cognitive Activity in Cognitive Functioning Among Older Adults
    Su Hyun Shin, Soohyun Park, Cheryl Wright, Valerie D’Astous, Giyeon Kim · 2020 · The Gerontologist
  58. Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol
    Neil Graham, Karl A. Zimmerman, Guido Bertolini, Sandra Magnoni, Mauro Oddo, Henrik Zetterberg, Federico Moro, Deborah Novelli, Amanda Heslegrave, Arturo Chieregato et al. · 2020 · BMJ Open
  59. Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer’s Disease
    Efthalia Angelopoulou, Christos Koros, Alexandros Hatzimanolis, Leonidas Stefanis, Nikolaos Scarmeas, Sokratis G. Papageorgiou · 2024 · International Journal of Molecular Sciences
  60. Pathway-specific polygenic scores for Alzheimer’s disease are associated with changes in brain structure in younger and older adults
    Judith Rose Harrison, Sonya F. Foley, Emily Ann Baker, Matthew Bracher‐Smith, Peter Holmans, Evie Stergiakouli, David E.J. Linden, Xavier Caseras, Derek Kenton Jones, Valentina Escott‐Price · 2023 · Brain Communications
  61. Late-Onset Alzheimer’s Disease Polygenic Risk Profile Score Predicts Hippocampal Function
    Ena Xiao, Qiang Chen, Aaron L. Goldman, Hao Yang Tan, K. Zachary Healy, Brad J. Zoltick, Saumitra Das, Bhaskar S. Kolachana, Joseph H. Callicott, Dwight Dickinson et al. · 2017 · Biological Psychiatry Cognitive Neuroscience and Neuroimaging
  62. PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
    Karin Lopatko Lindman, Caroline Jonsson, Bodil Weidung, Jan Olsson, Janardan P. Pandey, Dmitry Prokopenko, Rudolph E. Tanzi, Göran Hallmans, Sture Eriksson, Fredrik Elgh et al. · 2022 · Scientific Reports
  63. Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies
    Adam R. Smith, Jonathan S. Mill, Rebecca G. Smith, Katie Lunnon · 2016 · Neuroepigenetics
  64. Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls
    Escott-Price, Valentina, Baker, Emily, Shoai, Maryam, Leonenko, Ganna, Myers, Amanda J., Huentelman, Matt, Hardy, John · 2019 · Neurobiology of Aging
  65. Use of Deep-Learning Genomics to Discriminate Healthy Individuals from Those with Alzheimer’s Disease or Mild Cognitive Impairment
    Lanlan Li, Yeying Yang, Qi Zhang, Jiao Wang, Jiehui Jiang, Alzheimer’s Disease Neuroimaging Initiative · 2021 · Behavioural Neurology
  66. Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease
    Devashi Paliwal, Tim W. McInerney, Judy Pa, Russell Howard Swerdlow, Simon Easteal, Shea J. Andrews, for the Alzheimer’s Disease Neuroimaging Initiative · 2020 · Neurobiology of Aging
  67. A Blood Test for Alzheimer’s Disease: Progress, Challenges, and Recommendations
    Steven J. Kiddle, Nicola Voyle, Richard Dobson · 2018 · Journal of Alzheimer s Disease
  68. Exploring Beyond the DNA Sequence: A Review of Epigenomic Studies of DNA and Histone Modifications in Dementia
    Lachlan Ford MacBean, Adam R. Smith, Katie Lunnon · 2020 · Current Genetic Medicine Reports
  69. Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE‐ε4/TOMM40 long poly‐T repeat allele variants
    Inga Prokopenko, Gentaro Miyakawa, Bang Zheng, Jani Heikkinen, Daniela Petrova, Chinedu Theresa Udeh‐Momoh, Annique Claringbould, Juliane Neumann, Hazal Haytural, Marika Kaakinen et al. · 2019 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  70. Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness
    Vincenzo Muto, Ekaterina Koshmanova, Pouya Ghaemmaghami, Mathieu Jaspar, Christelle Meyer, Mahmoud Elansary, Maxime Van Egroo, Daphné Chylinski, Christian Berthomier, Marie Brandewinder et al. · 2020 · SLEEP
  71. Associations of risk genes with onset age and plasma biomarkers of Alzheimer’s disease: a large case–control study in mainland China
    Bin Jiao, Xuewen Xiao, Zhenhua Yuan, Lina Guo, Xinxin Liao, Yafang Zhou, Lu Zhou, Xin Wang, Xixi Liu, Hui Liu et al. · 2022 · Neuropsychopharmacology
  72. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer’s disease through polygenic risk and RNA sequencing
    Karen Crawford, Ganna Leonenko, Emily Ann Baker, Detelina Grozeva, Benoît Lan-Leung, Peter Holmans, Julie H. Williams, Michael C. O’Donovan, Valentina Escott‐Price, Dobril K. Ivanov · 2022 · Molecular Psychiatry
  73. Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers
    Nicholas J. Schork, Jeremy A. Elman, Alzheimer’s Disease Neuroimaging Initiative · 2023 · Journal of Alzheimer s Disease
  74. Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
    Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida et al. · 2024 · Alzheimer s Research & Therapy
  75. Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains
    Michael John Keogh, Wei Wei, Juvid Aryaman, Ian Wilson, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith et al. · 2018 · Journal of Neurology Neurosurgery & Psychiatry
  76. Key biomarkers in Alzheimer’s disease: Insights for diagnosis and treatment strategies
    Ruqaiya Jamal, Mohammad Abuzar Shaikh, Mohamad Taleuzzaman, Ziyaul Haque, Mohammed Albratty, Md Shamsher Alam, Hafiz Antar Makeen, Khalid A. Zoghebi, Safaa Fathy Saleh · 2025 · Journal of Alzheimer s Disease
  77. Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults
    Emma Susanne Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien M. Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick J. Dupont, Isabelle Cleynen et al. · 2022 · Alzheimer s Research & Therapy
  78. Cardiometabolic diseases, polygenic risk score, APOE genotype, and risk of incident dementia: A population-based prospective cohort study
    Yanchun Chen, Yuan Zhang, Shu Li, Lihui Zhou, Huiping Li, Dun Li, Yaogang Wang, Hongxi Yang · 2022 · Archives of Gerontology and Geriatrics
  79. Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
    Neelakshi Soni, Lindsay A. Hohsfield, Kristine M. Tran, Shimako Kawauchi, Amber Walker, Dominic I. Javonillo, Jimmy Phan, Dina P. Matheos, Celia Da Cunha, Asli Uyar et al. · 2024 · Alzheimer s & Dementia
  80. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid
    Nicola Voyle, the EDAR and DESCRIPA study groups and the Alzheimer’s Disease Neuroimaging Initiative, Hamel Patel, Amos Folarin, Stephen Newhouse, Caroline Johnston, Pieter Jelle Visser, Richard Dobson, Steven John Kiddle · 2016 · Journal of Alzheimer s Disease
  81. A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer’s Genetic Risk ( CLU + CR1 + PICALM ) Intensifies Cognitive Aging Genetic Risk ( COMT + BDNF ) Selectively for APOE ɛ 4 Carriers
    Shraddha Sapkota, Roger A. Dixon · 2018 · Journal of Alzheimer s Disease
  82. The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer’s Disease
    Grazia Daniela Femminella, Alzheimer’s Disease Neuroimaging Initiative, Denise H. Harold, James Scott, Julie H. Williams, Paul Edison · 2020 · Journal of Alzheimer s Disease
  83. Advances in Genetic and Molecular Understanding of Alzheimer’s Disease
    Laura Ibáñez, Carlos Cruchaga, María Victoria Fernández · 2021 · Genes
  84. Genome-Wide Meta-Analysis of Late-Onset Alzheimer’s Disease Using Rare Variant Imputation in 65,602 Subjects Identifies Novel Rare Variant Locus NCK2 : The International Genomics of Alzheimer’s Project (IGAP)
    Adam Christian Naj, Ganna Leonenko, Xueqiu Jian, Benjamin Grenier‐Boley, Maria Carolina Dalmasso, Céline Bellenguez, Sha Jin, Yi Zhao, Sven J. van der Lee, Rebecca Sims et al. · 2021 · medRxiv
  85. Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies
    Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao, Emily Simmonds, Ying Wu, Niklas Mattsson, Oskar Hansson, Michael W. Nagle, Valentina Escott‐Price et al. · 2025 · Alzheimer s Research & Therapy
  86. Functional co-activation of the default mode network in APOE ε4-carriers: A replication study
    Lara J. Mentink, Joao Guimaraes, Myrthe Faber, Emma Sprooten, Marcel G. M. Olde Rikkert, Koen V. Haak, Christian F. Beckmann · 2021 · NeuroImage
  87. Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
    Huq, Aamira J., Fulton‐Howard, Brian, Riaz, Moeen, Laws, Simon, Sebra, Robert, Ryan, Joanne, Alzheimer's Disease Genetics Consortium, Renton, Alan E., Goate, Alison M., Masters, Colin L. et al. · 2021 · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  88. A Pathway-Specific Polygenic Risk Score Is Associated with Tau Pathology and Cognitive Decline
    Yuqing Sun, Meng Wang, Yuxin Zhao, Ke Hu, Yong Liu, Bing Liu, Alzheimer’s Disease Neuroimaging Initiative · 2021 · Journal of Alzheimer s Disease
  89. Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes
    Nathaniel B. Gunter, Robel K Gebre, Jonathan Graff‐Radford, Michael G. Heckman, Clifford R. Jack, Val J. Lowe, David S. Knopman, Ronald Carl Petersen, Owen A. Ross, Prashanthi Vemuri et al. · 2024 · Neurology Genetics
  90. Searching the Dark Genome for Alzheimer’s Disease Risk Variants
    Rachel Raybould, Rebecca Sims · 2021 · Brain Sciences
  91. The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer’s disease
    Gongbu Pan, Anna Elizabeth King, Feitong Wu, Steve Simpson, Adele Woodhouse, Andrew Phipps, James Clement Vickers · 2021 · Ageing Research Reviews
  92. Pitfalls of predicting age‐related traits by polygenic risk scores
    Valentina Escott‐Price, Karl Michael Schmidt · 2023 · Annals of Human Genetics
  93. The PANoptosis-related hippocampal molecular subtypes and key biomarkers in Alzheimer’s disease patients
    Chen‐Long Li, Qi Wang, Li Wu, Jing-Yi Hu, Qi-Chao Gao, Xin-long Jiao, Yuxiang Zhang, Shan Tang, Yu Ming Qi, P. F. He · 2024 · Scientific Reports
  94. A Machine Learning Method to Identify Genetic Variants Potentially Associated With Alzheimer’s Disease
    Bradley Monk, Andrei Rajkovic, Semar Petrus, Aleks Rajkovic, Terry Gaasterland, Roberto Malinow · 2021 · Frontiers in Genetics
  95. Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer’s Disease
    Hongliang Liu, Alzheimer’s Disease Neuroimaging Initiative, Michael William Lutz, Sheng Luo · 2021 · Journal of Alzheimer s Disease
  96. DNA Modifications and Alzheimer’s Disease
    Rebecca G. Smith, Katie Lunnon · 2017 · Advances in experimental medicine and biology
  97. Genetic variants in glutamate-, Aβ−, and tau-related pathways determine polygenic risk for Alzheimer's disease
    Ted Lawingco, Sultan Raja Chaudhury, Keeley J. Brookes, Tamar Guetta‐Baranes, Rita João Guerreiro, José Brás, John Hardy, Paul T. Francis, Alan J. Thomas, Olivia Belbin et al. · 2020 · Neurobiology of Aging
  98. Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores
    de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolò, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris, Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel et al. · 2019
  99. Alzheimer's disease
    Alberto Serrano‐Pozo, Valentina Escott‐Price, Lea T. Grinberg, Tharick Ali Pascoal, Marc Suárez‐Calvet, Bruno Dubois, Reisa Anne Sperling · 2026 · The Lancet
  100. Polygenic risk scores for Alzheimer’s disease, and academic achievement, cognitive and behavioural measures in children from the general population
    Roxanna Korologou‐Linden, Emma L. Anderson, Hannah J Jones, George Davey Smith, Laura D Howe, Evie Stergiakouli · 2019 · International Journal of Epidemiology