Cited by 39Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA regulation and disease

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

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Salemi, Michele, Mogavero, Maria Paola, Lanza, Giuseppe, Mongioì, Laura M., Calogero, Aldo E., Ferri, Raffaele·2022·Cells

Abstract

Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.

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Crossref · 10.3390/cells11121930

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  • Aberrant miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders.

    “aberrant miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders, etc.230,231”

    From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [231]

    Section 7 (Conclusions; page not available) describes miRNA deregulation in cancer, and Section 5 links altered miRNA expression to Alzheimer’s disease. Section 6.3 mentions an association with lipid metabolism, but does not establish a contribution to metabolic disease. The cited paper does not support the additional claims about cardiovascular or immune-mediated disorders. (LLM, conf=0.86)

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Authors
Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R.
Affiliations
  • Istituti di Ricovero e Cura a Carattere Scientifico (IT)
  • Istituti Clinici Scientifici Maugeri (IT)
  • University of Catania (IT)
Corresponding author
Salemi, Michele
Venue
Cells
Publisher
MDPI AG
Published
2022-06-15
Volume
11
Issue
12
Pages
1930
ISSN
2073-4409 (ISSN-L)
OpenAlex
W4282972028
Cited by
39
References
237
Citations by year
2026: 3 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Italian Ministry of Health (2773804)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
cancer, neurodegenerative diseases, non-coding RNA, Alzheimer's disease, Parkinson's disease, PARP1
MeSH terms
Alzheimer Disease, Humans, Neoplasms, Parkinson Disease, Comorbidity, Neurodegenerative Diseases, RNA, Untranslated

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