Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease

Cites (300)

Items 201–300 of 300

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9. Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures
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10. Oncogenic Property of Acrogranin in Human Uterine Leiomyosarcoma: Direct Evidence of Genetic Contribution in In vivo Tumorigenesis
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12. Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1
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13. Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis
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14. Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test
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15. Progranulin Reduction Is Associated With Increased Tau Phosphorylation in P301L Tau Transgenic Mice
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16. The zebrafish progranulin gene family and antisense transcripts
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17. Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis
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18. Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis‐like skin inflammation
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19. Progranulin does not inhibit TNF and lymphotoxin‐α signalling through TNF receptor 1
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20. Recent Advances in the Genetics of the ALS-FTLD Complex
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21. PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway
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22. Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: a longitudinal arterial spin labeling study
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23. Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways
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24. Neuroprotective effects of progranulin in ischemic mice
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25. Progranulin overexpression predicts overall survival in patients with glioblastoma
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26. Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study
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27. Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation
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28. The EGF-like Homeotic Protein dlk Affects Cell Growth and Interacts with Growth-Modulating Molecules in the Yeast Two-Hybrid System
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29. Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers
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30. Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins
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31. Loss of exosomes in progranulin-associated frontotemporal dementia
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32. Progranulin Resolves Inflammation
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33. Promoter DNA methylation regulates progranulin expression and is altered in FTLD
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34. The Emerging Roles of MicroRNAs in the Pathogenesis of Frontotemporal Dementia–Amyotrophic Lateral Sclerosis (FTD-ALS) Spectrum Disorders
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35. Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy
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36. Update on Frontotemporal Dementia
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37. Expression of Progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in Benign and Malignant Ovarian Tumors and Activation of MAPK Signaling in Ovarian Cancer Cell Line
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38. Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency
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39. Roles of Progranulin in Sexual Differentiation of the Developing Brain and Adult Neurogenesis
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40. Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy
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41. Age-Dependent Changes in Progranulin Expression in the Mouse Brain
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42. Progranulin (GRN)in two siblings of a Latino family and in other patients with Schizophrenia
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43. Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs
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44. Distinct pathways leading to TDP-43-induced cellular dysfunctions
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45. Progranulin (PGRN) expression in ALS: An immunohistochemical study
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46. Pilot Trial of Memantine in Primary Progressive Aphasia
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47. The Granulin–Epithelin Precursor: A Putative New Growth Factor for Ovarian Cancer
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48. Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models
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49. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration
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50. Towards the next generation of anti-TNF drugs
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51. Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?
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52. Inhibition of Toll-like Receptor Signaling in Primary Murine Microglia
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53. Clinical variability and female penetrance in X-linked familial FTD/ALS caused by a P506S mutation in UBQLN2
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54. Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2
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55. Progranulin A-mediated MET Signaling Is Essential for Liver Morphogenesis in Zebrafish
    Yen-Hsing Li, Mark Hung‐Chih Chen, Hong‐Yi Gong, Shao‐Yang Hu, Ya‐Wen Li, Gen-Hwa Lin, Ching-Chun Lin, Wangta Liu, Jen‐Leih Wu · 2010 · Journal of Biological Chemistry
56. Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs
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57. Clinicopathological description of two cases with SQSTM1 gene mutation associated with frontotemporal dementia
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58. Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation
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59. Serum Progranulin Levels in Patients with Frontotemporal Lobar Degeneration and Alzheimer's Disease: Detection of GRN Mutations in a Spanish Cohort
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60. Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells
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61. TDP‐43 toxicity is mediated by the unfolded protein response‐unrelated induction of C/EBP homologous protein expression
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62. Progranulin Peripheral Levels as a Screening Tool for the Identification of Subjects with Progranulin Mutations in a Portuguese Cohort
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63. GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil
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64. In vivo and Postmortem Clinicoanatomical Correlations in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17
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65. Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis
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66. In Silico Comparison of the Transcriptome Derived from Purified Normal Breast Cells and Breast Tumor Cell Lines Reveals Candidate Upregulated Genes in Breast Tumor Cells
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67. Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression
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68. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus
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69. PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers
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70. Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation
    Hyun-Kyong Kim, Mi-Seon Shin, Byung‐Soo Youn, Cherl NamKoong, So Young Gil, Gil Myoung Kang, Ji Hee Yu, Min‐Seon Kim · 2011 · Endocrinology
71. Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice
    Hee‐Young Lim, Boris Albuquerque, Annett Häußler, Thekla Myrczek, Aihao H. Ding, Irmgard Tegeder · 2011 · Journal of Cellular and Molecular Medicine
72. Progranulin and short‐term outcome in patients with acute ischaemic stroke
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73. Progranulin variability has no major role in Parkinson disease genetic etiology
    Karen Nuytemans, Ph. Pals, Kristel Sleegers, Sebastiaan Engelborghs, Ellen Corsmit, Karin Peeters, Barbara Anne Pickut, Maria Mattheijssens, Patrick P Cras, Peter P. De Deyn et al. · 2008 · Neurology
74. Progranulin and β-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation Carrier
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75. The Granulin-Epithelin Precursor Is a Steroid-Regulated Growth Factor in Endometrical Cancer
    Monica B. Jones, Aletta P. I. Houwink, Brandi Kaye Freeman, Tammy M. Greenwood, Jacqueline M. Lafky, Wilma L. Lingle, Andrew Berchuck, George L. Maxwell, Karl C. Podratz, Nita J. Maihle · 2006 · Journal of the Society for Gynecologic Investigation
76. Alzheimer neuropathology without frontotemporal lobar degeneration hallmarks ( TAR DNA ‐binding protein 43 inclusions) in missense progranulin mutation C ys139 A rg
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77. Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology
    Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid · 2015 · PLoS ONE
78. Progranulin Mutations are a Common Cause of FTLD in Northern Italy
    Luisa Benussi, Roberta Ghidoni, Giuliano Gb. Binetti · 2010 · Alzheimer Disease & Associated Disorders
79. Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder
    Daniela Galimberti, Cecilia Prunas, Riccardo Augusto Paoli, Bernardo Maria Dell’Osso, Chiara Fenoglio, Chiara Villa, Carlotta Palazzo, Michela Cigliobianco, G. Camuri, María Serpente et al. · 2014 · Bipolar Disorders
80. A thorough assessment of benign genetic variability inGRNandMAPT
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81. Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS
    Babykumari P. Chitramuthu, Denis George Kay, Andrew Bateman, H.P.J. Bennett · 2017 · PLoS ONE
82. Frontotemporal Lobar Degeneration
    Enrico Premi, Alessandro Padovani, Barbara Borroni · 2012 · Advances in experimental medicine and biology
83. Amyotrophic lateral sclerosis‐linked mutant VAPB enhances TDP‐43‐induced motor neuronal toxicity
    Hiroaki Suzuki, Masaaki Matsuoka · 2011 · Journal of Neurochemistry
84. Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
    Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf‐Strathmann, Lubina Dillen et al. · 2015 · Acta Neuropathologica Communications
85. C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
    Marc Cruts, Sebastiaan Engelborghs, Julie van der Zee, Christine Van Broeckhoven · 2015 · VUBIR (Vrije Universiteit Brussel)
86. Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males
    Chiara Fenoglio, Diego Scalabrini, Federica Esposito, Cristoforo Comi, Paola Cavalla, Milena Alessandra De Riz, Vittorio Martinelli, Laura M. Piccio, Eliana Venturelli, Giorgio Fumagalli et al. · 2010 · Genes and Immunity
87. Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration
    Ana de la Encarnación, Carolina Alquézar, Ángeles Martín‐Requero · 2015 · Molecular Neurobiology
88. Association Between Progranulin and β-Amyloid in Dementia With Lewy Bodies
    Gonzalo J. Revuelta, Andrea L. Rosso, Carol Frances Lippa · 2008 · American Journal of Alzheimer s Disease & Other Dementias®
89. No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort
    Roberto Del Bo, Stefania Paola Corti, Domenico Santoro, Isabella Ghione, Chiara Fenoglio, Serena Ghezzi, Michela Ranieri, Daniela Galimberti, Michelangelo Mancuso, Gabriele Siciliano et al. · 2009 · Neurobiology of Aging
90. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
    Sakura Minami, Vivian Shen, David Le, Grietje Krabbe, Rustam Asgarov, Liberty Perez-Celajes, Chih‐Hung Lee, Jinhe Li, Diana L. Donnelly‐Roberts, Li Gan · 2015 · Biochemical Pharmacology
91. Progranulin expression in neural stem cells and their differentiated cell lineages: An immunocytochemical study
    Lanhai Lü, Li Luo, Yinghong Lu, Lizhi Chen, JIE XU, Kaihua Guo · 2013 · Molecular Medicine Reports
92. The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels
    Amanda R. Mason, Lisa P. Elia, Steven M. Finkbeiner · 2017 · Journal of Biological Chemistry
93. The Neuroimaging Signature of Frontotemporal Lobar Degeneration Associated with Granulin Mutations: An Effective Connectivity Study
    Enrico Premi, Mario Grassi, Stefano Gazzina, Barbara Paghera, Daniele Pepe, Silvana Archetti, Alessandro Padovani, Barbara Borroni · 2013 · Journal of Nuclear Medicine
94. Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
    Babykumari P. Chitramuthu, Andrew Bateman · 2016 · The Journal of Cell Biology
95. GRN-Related Frontotemporal Dementia
    Ging‐Yuek Robin Hsiung, Howard Feldman · 2013
96. Progranulin protects against the tissue damage of acute ischaemic stroke: Figure 1
    Chunyu Zhao, Andrew Bateman · 2015 · Brain
97. Novel progranulin variants do not disrupt progranulin secretion and cleavage
    Celeste M M. Karch, Amanda T. Jeng, Tara Skorupa, Carlos Cruchaga, Alison Goate · 2013 · Neurobiology of Aging
98. A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation.
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99. Correlation of granulin expression in intracranial meningiomas to clinical parameters
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100. Cortical degeneration in frontotemporal lobar degeneration with TDP-43 proteinopathy caused byprogranulingene mutation
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