Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.093 · Cited by 2,732 · see citing works

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Baker, M., Mackenzie, I. R., Pickering-Brown, S. M., Gass, J., Rademakers, R., Lindholm, C., Snowden, J., Adamson, J., Sadovnick, A. D., Rollinson, S., et al. (2006) · Nature · doi:10.1038/nature05016 · Cited by 2,058 · see citing works

The activation of Akt/PKB signaling pathway and cell survival

Song, G., Ouyang, G., & Bao, S. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00337.x · Cited by 1,891 · see citing works

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Säftig, P., & Klumperman, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2745 · Cited by 1,702 · see citing works

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Cruts, M., Gijselinck, I., van der Zee, J., Engelborghs, S., Wils, H., Pirici, D., Rademakers, R., Vandenberghe, R., Dermaut, B., Martin, J.-J., et al. (2006) · Nature · doi:10.1038/nature05017 · Cited by 1,512 · see citing works

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

Watts, G. D. J., Wymer, J., Kovach, M. J., Mehta, S. G., Mumm, S., Darvish, D., Pestronk, A., Whyte, M. P., & Kimonis, V. E. (2004) · Nature Genetics · doi:10.1038/ng1332 · Cited by 1,391 · see citing works

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Roczniak-Ferguson, A., Petit, C. S. V., Froehlich, F., Qian, S., Ky, J., Angarola, B. L., Walther, T. C., & Ferguson, S. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002790 · Cited by 1,358 · see citing works

Genetic compensation induced by deleterious mutations but not gene knockdowns

Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., & Stainier, D. Y. R. (2015) · Nature · doi:10.1038/nature14580 · Cited by 1,249 · see citing works

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Deng, H.-X., Chen, W., Hong, S.-T., Boycott, K. M., Gorrie, G. H., Siddique, N., Yang, Y., Fecto, F., Shi, Y., Zhai, H., et al. (2011) · Nature · doi:10.1038/nature10353 · Cited by 1,174 · see citing works

A harmonized classification system for FTLD-TDP pathology

Mackenzie, I. R., Neumann, M., Baborie, A., Sampathu, D. M., du Plessis, D., Jaros, E., Perry, R. H., Trojanowski, J. Q., Mann, D. M. A., & Lee, V. M. ‐. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0845-8 · Cited by 1,013 · see citing works

Sortilin is essential for proNGF-induced neuronal cell death

Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., et al. (2004) · Nature · doi:10.1038/nature02319 · Cited by 962 · see citing works

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Skibinski, G., Parkinson, N. J., Brown, J. M., Chakrabarti, L., Lloyd, S. L., Hummerich, H., Nielsen, J. E., Hodges, J. R., Spillantini, M. G., Thusgaard, T., et al. (2005) · Nature Genetics · doi:10.1038/ng1609 · Cited by 822 · see citing works

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

Tang, W., Lu, Y., Tian, Q.-Y., Zhang, Y., Guo, F.-J., Liu, G.-Y., Syed, N. M., Lai, Y., Lin, E. A., Kong, L., et al. (2011) · Science · doi:10.1126/science.1199214 · Cited by 761 · see citing works

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729 · see citing works

The overlap of amyotrophic lateral sclerosis and frontotemporal dementia

Lomen, C. E., Anderson, T. T., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.59.7.1077 · Cited by 699 · see citing works

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

Mottamal, M., Zheng, S., Huang, T. L., & Wang, G. (2015) · Molecules · doi:10.3390/molecules20033898 · Cited by 687 · see citing works

Conversion of Proepithelin to Epithelins

Zhu, J. K., Nathan, C., Jin, W., Sim, D., Ashcroft, G. S., Wahl, S. M., Lacomis, L., Erdjument‐Bromage, H., Tempst, P., Wright, C. D., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01141-8 · Cited by 628 · see citing works

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L.-S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.536 · Cited by 579 · see citing works

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

Gass, J. M., Cannon, A. D., Mackenzie, I. R., Boeve, B. F., Baker, M. C., Adamson, J. L., Crook, R., Melquist, S., Kuntz, K., Petersen, R. C., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl241 · Cited by 574 · see citing works

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

Hu, F., Padukkavidana, T., Vægter, C. B., Brady, O. A., Zheng, Y., Mackenzie, I. R., Feldman, H., Nykjær, A., & Strittmatter, S. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.034 · Cited by 545 · see citing works

The epidemiology of frontotemporal dementia

Onyike, C. U., & Diehl-Schmid, J. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776523 · Cited by 543 · see citing works

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

Rohrer, J. D., Nicholas, J. M., Cash, D. M., van Swieten, J., Dopper, E., Jiskoot, L., van Minkelen, R., Rombouts, S. A., Cardoso, M. J., Clegg, S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70324-2 · Cited by 538 · see citing works

Progranulin is a mediator of the wound response

He, Z., Ong, C. H. P., Halper, J., & Bateman, A. (2003) · Nature Medicine · doi:10.1038/nm816 · Cited by 490 · see citing works

Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage

Smith, K. R., Damiano, J., Franceschetti, S., Carpenter, S., Canafoglia, L., Morbin, M., Rossi, G., Pareyson, D., Mole, S. E., Staropoli, J. F., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.04.021 · Cited by 489 · see citing works

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

Yin, F., Banerjee, R., Thomas, B., Zhou, P., Qian, L., Jia, T., Ma, X., Ma, Y., Iadecola, C., Beal, M. F., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091568 · Cited by 480 · see citing works

Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

He, Z., & Bateman, A. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0474-3 · Cited by 470 · see citing works

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Damme, P. V., Hoecke, A. V., Lambrechts, D., Vanacker, P., Bogaert, E., Swieten, J. C. V., Carmeliet, P., Bosch, L. V. D., & Robberecht, W. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712039 · Cited by 421 · see citing works

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

Ashcroft, G. S., Lei, K.-J., Jin, W., Longenecker, G., Kulkarni, A. B., Greenwell‐Wild, T., Hale‐Donze, H., McGrady, G., Song, X.-Y., & Wahl, S. M. (2000) · Nature Medicine · doi:10.1038/80489 · Cited by 417 · see citing works

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

Gowrishankar, S., Yuan, P., Wu, Y., Schrag, M., Paradise, S., Grutzendler, J., De Camilli, P., & Ferguson, S. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510329112 · Cited by 406 · see citing works

Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics

Whitwell, J. L., Weigand, S. D., Boeve, B. F., Senjem, M. L., Gunter, J. L., DeJesus-Hernandez, M., Rutherford, N. J., Baker, M., Knopman, D. S., Wszolek, Z. K., et al. (2012) · Brain · doi:10.1093/brain/aws001 · Cited by 397 · see citing works

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

Finch, N. A., Baker, M., Crook, R., Swanson, K. R., Kuntz, K., Surtees, R., Bisceglio, G. D., Rovelet‐Lecrux, A., Boeve, B. F., Petersen, R. C., et al. (2009) · Brain · doi:10.1093/brain/awn352 · Cited by 382 · see citing works

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

Mackenzie, I. R., & Neumann, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13588 · Cited by 374 · see citing works

Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

Zhang, Y., Xu, Y.-F., Dickey, C. A., Buratti, E., Baralle, F. E., Bailey, R. M., Pickering-Brown, S. M., Dickson, D. W., & Petrucelli, L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3421-07.2007 · Cited by 371 · see citing works

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

Kessenbrock, K., Fröhlich, L. F., Sixt, M., Lämmermann, T., Pfister, H., Bateman, A., Belaaouaj, A., Ring, J., Ollert, M. W., Fässler, R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34694 · Cited by 363 · see citing works

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

Igaz, L. M., Kwong, L. K., Chen‐Plotkin, A. S., Winton, M. J., Unger, T. L., Xu, Y., Neumann, M., Trojanowski, J. Q., & Lee, V. M. ‐. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809462200 · Cited by 357 · see citing works

Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study

Ber, I. L., Camuzat, A., Hannequin, D., Pasquier, F., Guedj, É., Rovelet‐Lecrux, A., Hahn‐Barma, V., van der Zee, J., Clot, F., Bakchine, S., et al. (2008) · Brain · doi:10.1093/brain/awn012 · Cited by 348 · see citing works

Cellular Localization of Gene Expression for Progranulin

DANIEL, R. L., He, Z., Carmichael, K. P., Halper, J. T., & Bateman, A. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800713 · Cited by 346 · see citing works

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

Martens, L. H., Zhang, J., Barmada, S. J., Zhou, P., Kamiya, S., Sun, B., Min, S.-W., Gan, L., Finkbeiner, S. M., Huang, E. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63113 · Cited by 313 · see citing works

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Pottier, C., Bieniek, K. F., Finch, N., van de Vorst, M., Baker, M., Perkersen, R., Brown, P., Ravenscroft, T., van Blitterswijk, M., Nicholson, A. M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1436-x · Cited by 312 · see citing works

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

Ghidoni, R., Benussi, L., Glionna, M., Franzoni, M., & Binetti, G. G. (2008) · Neurology · doi:10.1212/01.wnl.0000325058.10218.fc · Cited by 300 · see citing works

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene

Mackenzie, I. R., Baker, M., Pickering-Brown, S. M., Hsiung, G. R., Lindholm, C., Dwosh, E., Gass, J. M., Cannon, A. D., Rademakers, R., Hutton, M., et al. (2006) · Brain · doi:10.1093/brain/awl271 · Cited by 294 · see citing works

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

Ahmed, Z., Sheng, H., Xu, Y.-F., Lin, W.-L., Innes, A. E., Gass, J. M., Yu, X., Hou, H., Chiba, S., Yamanouchi, K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090915 · Cited by 293 · see citing works

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

Rademakers, R., Eriksen, J. L., Baker, M. C., Robinson, T., Ahmed, Z., Lincoln, S., Finch, N. A., Rutherford, N. J., Crook, R., Josephs, K. A., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn257 · Cited by 290 · see citing works

The genetics and neuropathology of frontotemporal lobar degeneration

Sieben, A., Van Langenhove, T., Engelborghs, S., Martin, J.-J., Boon, P., Cras, P., De Deyn, P.-P., Santens, P., Van Broeckhoven, C., & Cruts, M. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1029-x · Cited by 280 · see citing works

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

Cohen, T. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.004 · Cited by 271 · see citing works

Differential roles of the ubiquitin proteasome system (UPS) and autophagy in the clearance of soluble and aggregated TDP-43 species

Scotter, E. L., Vance, C. A., Nishimura, A. L., Lee, Y., Chen, H.-J., Urwin, H., Sardone, V., Mitchell, J. C., Rogelj, B., Rubinsztein, D. C., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.140087 · Cited by 265 · see citing works

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.

Bhandari, V., Palfree, R. G. E., & Bateman, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1715 · Cited by 244 · see citing works

<i>TMEM106B</i> regulates progranulin levels and the penetrance of FTLD in <i>GRN</i> mutation carriers

Finch, N., Carrasquillo, M. M., Baker, M., Rutherford, N. J., Coppola, G., DeJesus-Hernandez, M., Crook, R., Hunter, T., Ghidoni, R., Benussi, L., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31820a0e3b · Cited by 243 · see citing works

Mutation within TARDBP leads to Frontotemporal Dementia without motor neuron disease

Borroni, B., Bonvicini, C., Alberici, A., Buratti, E., Agosti, C., Archetti, S., Papetti, A., Stuani, C., Luca, M. D., Gennarelli, M., et al. (2009) · Human Mutation · doi:10.1002/humu.21100 · Cited by 241 · see citing works

TMEM106B , the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

Chen‐Plotkin, A. S., Unger, T. L., Gallagher, M. D., Bill, E., Kwong, L. K., Volpicelli‐Daley, L. A., Busch, J. I., Akle, S., Grossman, M., Deerlin, V. M. V., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0521-12.2012 · Cited by 239 · see citing works

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Minami, S. S., Min, S.-W., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L. H., Elia, L. P., Ward, M. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3672 · Cited by 237 · see citing works

Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations

Rohrer, J. D., Ridgway, G. R., Marc Modat, A., Sebastien Ourselin, A., Mead, S., Fox, N. C., Rossor, M. N., & Warren, J. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.088 · Cited by 235 · see citing works

C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis

Rohrer, J. D., Isaacs, A. M., Mizielinska, S., Mead, S., Lashley, T., Wray, S., Sidle, K. C. L., Fratta, P., Orrell, R. W., Hardy, J., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70233-9 · Cited by 234 · see citing works

Insights into the role of progranulin in immunity, infection, and inflammation

Jian, J., Konopka, J., & Liu, C.-J. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0812429 · Cited by 233 · see citing works

Novel Ubiquitin Neuropathology in Frontotemporal Dementia WithValosin-Containing ProteinGene Mutations

Forman, M. S., Mackenzie, I. R., Cairns, N. J., Swanson, E., Boyer, P. J., Drachman, D. A., Jhaveri, B. S., Karlawish, J. H., Pestronk, A., Smith, T. W., et al. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-200606000-00005 · Cited by 226 · see citing works

A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series

Beck, J. A., Rohrer, J. D., Campbell, T., Isaacs, A. M., Morrison, K. E., Goodall, G., Warrington, E. K., Stevens, J., Révész, T., Holton, J. L., et al. (2008) · Brain · doi:10.1093/brain/awm320 · Cited by 226 · see citing works

Genetic contribution of FUS to frontotemporal lobar degeneration

Langenhove, T. V., van der Zee, J., Sleegers, K., Engelborghs, S., Vandenberghe, R. R., Gijselinck, I., den Broeck, M. V., Mattheijssens, M., Peeters, K., Deyn, P. P. D., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ccc732 · Cited by 217 · see citing works

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

Malaspina, A., Kaushik, N. K., & de Belleroche, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00231.x · Cited by 212 · see citing works

Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative

Rademakers, R., Baker, M. C., Gass, J. M., Adamson, J. L., Huey, E. D., Momeni, P., Spina, S., Coppola, G., Karydas, A. M., Stewart, H. G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70221-1 · Cited by 211 · see citing works

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

Moisse, K., Volkening, K., Leystra-Lantz, C., Welch, I., Hill, T., & Strong, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2008.10.021 · Cited by 210 · see citing works

Toward Selective Histone Deacetylase Inhibitor Design: Homology Modeling, Docking Studies, and Molecular Dynamics Simulations of Human Class I Histone Deacetylases

Wang, D., Helquist, P. M., Wiech, N. L., & Wiest, O. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0505011 · Cited by 210 · see citing works

Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

Zhou, J., Gao, G., Crabb, J. W., & Serrero, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82064-6 · Cited by 206 · see citing works

Granulins, a novel class of peptide from leukocytes

Bateman, A., Belcourt, D., Bennett, H. P. J., Lazure, C., & Solomon, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80908-8 · Cited by 206 · see citing works

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

Brady, O. A., Zheng, Y., Murphy, K. A., Huang, M. J., & Hu, F. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds475 · Cited by 205 · see citing works

Serum biomarker for progranulin‐associated frontotemporal lobar degeneration

Sleegers, K., Brouwers, N., Damme, P. V., Engelborghs, S., Gijselinck, I., van der Zee, J., Peeters, K., Mattheijssens, M., Cruts, M., Vandenberghe, R. R., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21621 · Cited by 204 · see citing works

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

Elkabets, M., Gifford, A. M., Scheel, C., Nilsson, B., Reinhardt, F., Bray, M.-A., Carpenter, A. E., Jirström, K., Magnusson, K., Ebert, B. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43757 · Cited by 201 · see citing works

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Zhou, X., Sun, L., de Oliveira, F. M. B., Qi, X., Brown, W. J., Smolka, M. B., Sun, Y., & Hu, F. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201502029 · Cited by 201 · see citing works

The Spectrum of Mutations in Progranulin: A Collaborative Study Screening 545 Cases of Neurodegeneration

Yu, C.-E., Bird, T. D., Bekris, L. M., Montine, T. J., Leverenz, J. B., Steinbart, E., Galloway, N. M., Feldman, H., Woltjer, R., Miller, C. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.328 · Cited by 190 · see citing works

Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene

Kayasuga, Y., Chiba, S., Suzuki, M., Kikusui, T., Matsuwaki, T., Yamanouchi, K., Kotaki, H., Horai, R., Iwakura, Y., & Nishihara, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.020 · Cited by 189 · see citing works

The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.

Plowman, G. D., Green, J. M., Neubauer, M., Buckley, S., McDonald, V. L., Todaro, G. J., & SHOYAB, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42382-4 · Cited by 189 · see citing works

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin‐positive, tau‐negative inclusions caused by a missense mutation in the signal peptide of progranulin

Mukherjee, O., Pástor, P., Cairns, N. J., Chakraverty, S., Kauwe, J. S. K., Shears, S., Behrens, M. I., Budde, J., Hinrichs, A. L., Norton, J. B., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20963 · Cited by 187 · see citing works

Association of TMEM106B Gene Polymorphism With Age at Onset in Granulin Mutation Carriers and Plasma Granulin Protein Levels

Cruchaga, C., Graff, C., Chiang, H., Wang, J., Hinrichs, A. L., Spiegel, N., Bertelsen, S. E., Mayo, K., Norton, J. B., Morris, J. C., et al. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.350 · Cited by 186 · see citing works

SQSTM1Mutations in French Patients With Frontotemporal Dementia or Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

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Biological activities and signaling pathways of the granulin/epithelin precursor.

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PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

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Portuguese family with the co-occurrence of frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis phenotypes due to progranulin gene mutation

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A Novel Interaction between Perlecan Protein Core and Progranulin

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Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption.

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Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma

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Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images

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Cellular Effects of Progranulin in Health and Disease

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A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

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Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

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Frontotemporal lobar degeneration: current perspectives

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Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD

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Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

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Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

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ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor

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Progranulin: A promising therapeutic target for rheumatoid arthritis

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Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

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Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

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Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function

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Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity

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Progranulin protects against renal ischemia/reperfusion injury in mice

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C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking

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Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma

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Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

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Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

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Common Variant in GRN Is a Genetic Risk Factor for Hippocampal Sclerosis in the Elderly

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Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model

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Progranulin Deficiency Promotes Post-Ischemic Blood–Brain Barrier Disruption

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Progranulin locus deletion in frontotemporal dementia

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Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease

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Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS

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Brain Magnetic Resonance Imaging Structural Changes in a Pedigree of Asymptomatic Progranulin Mutation Carriers

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Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

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Prosaposin is a regulator of progranulin levels and oligomerization

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MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

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Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses

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Corticobasal Syndrome Associated With the A9D Progranulin Mutation

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rs5848 polymorphism and serum progranulin level

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Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia

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Progranulin expression correlates with dense‐core amyloid plaque burden in Alzheimer disease mouse models

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Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease

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Pathogenic cysteine mutations affect progranulin function and production of mature granulins

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Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium

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Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

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Extensive White Matter Involvement in Patients With Frontotemporal Lobar Degeneration

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Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia

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Voxel-Based Morphometry in Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions With and Without Progranulin Mutations

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Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

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Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

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Heterogeneity within a large kindred with frontotemporal dementia: A novel progranulin mutation

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Amyloid β and Tau Alzheimer’s disease related pathology is reduced by Toll-like receptor 9 stimulation

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Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

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Delayed inflammatory mRNA and protein expression after spinal cord injury

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The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding

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Can Trehalose Prevent Neurodegeneration? Insights from Experimental Studies

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Structure and chromosomal location of the human granulin gene

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Proepithelin Regulates Prostate Cancer Cell Biology by Promoting Cell Growth, Migration, and Anchorage-Independent Growth

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The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

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Progranulin expression is upregulated after spinal contusion in mice

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Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin–epithelin precursor (GEP), a prosurvival factor for ovarian cancer

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Brain progranulin expression in GRN-associated frontotemporal lobar degeneration

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Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein

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The Evolution of the Secreted Regulatory Protein Progranulin

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Impaired protein degradation in FTLD and related disorders

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Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness

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Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium.

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Increased caspase activation and decreased TDP‐43 solubility in progranulin knockout cortical cultures

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Microglia in neurodegeneration

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Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study

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Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

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Fluid biomarkers in frontotemporal dementia: past, present and future

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Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

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Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle

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An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome

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Targeting the NF-κB Pathway for Therapy of Ischemic Stroke

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TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity.

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Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases

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Frontotemporal Dementia

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Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism

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Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases

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Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results

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Progranulin attenuates liver fibrosis by downregulating the inflammatory response

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Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia

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Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

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Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

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Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer’s disease

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Tracking disease progression in familial and sporadic frontotemporal lobar degeneration: recent findings from ARTFL and LEFFTDS

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Effects of Palmitoylethanolamide Combined with Luteoline on Frontal Lobe Functions, High Frequency Oscillations, and GABAergic Transmission in Patients with Frontotemporal Dementia

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Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses

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Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

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The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation

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N-Acetyl-Cysteine: Modulating the Cysteine Redox Proteome in Neurodegenerative Diseases

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Granulins modulate liquid–liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43

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Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging

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Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia

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Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

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Surf4, cargo trafficking, lipid metabolism, and therapeutic implications

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AZP2006, a new promising treatment for Alzheimer’s and related diseases

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Progranulin promotes hippocampal neurogenesis and alleviates anxiety‐like behavior and cognitive impairment in adult mice subjected to cerebral ischemia

Sun, S., Zhou, J., Li, Z., Wu, Y., Wang, H., Zheng, Q., Adu‐Nti, F., Fan, J., & Tian, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13810 · Cited by 33 · see citing works

Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase

Takahashi, H., Bhagwagar, S. Z., Nies, S. H., Ye, H., Han, X., Chiasseu, M., Wang, G., Mackenzie, I. R., & Strittmatter, S. M. (2024) · Nature Communications · doi:10.1038/s41467-024-45692-3 · Cited by 32 · see citing works

Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system

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CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?

Körtvélyessy, P., Heinze, H. J., Prudlo, J., & Bittner, D. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00504 · Cited by 31 · see citing works

A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation

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The Microglial Response to Neurodegenerative Disease

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Unravelling Genetic Factors Underlying Corticobasal Syndrome: A Systematic Review

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Modeling Lysosomal Storage Diseases in the Zebrafish

Zhang, T., & Peterson, R. T. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00082 · Cited by 26 · see citing works

Progranulin released from microglial lysosomes reduces neuronal ferroptosis after cerebral ischemia in mice

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Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Thomas, R., Moloney, E. B., Macbain, Z. K., Hallett, P. J., & Ole Isacson, A. (2021) · Molecular Brain · doi:10.1186/s13041-020-00712-3 · Cited by 25 · see citing works

Progranulin Oncogenic Network in Solid Tumors

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Progranulin as a therapeutic target for dementia

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Charge and redox states modulate granulin—TDP-43 coacervation toward phase separation or aggregation

Bhopatkar, A. A., Dhakal, S., Abernathy, H. G., Morgan, S. E., & Rangachari, V. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.04.034 · Cited by 23 · see citing works

Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells

Gawęda-Walerych, K., Aragona, V., Lodato, S., Sitek, E. J., Narożańska, E., & Buratti, E. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00475-8 · Cited by 22 · see citing works

Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides

Kuang, L., Hashimoto, K., Huang, E. J., Gentry, M. S., & Zhu, H. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz280 · Cited by 21 · see citing works

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β

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A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Swift, I. J., Rademakers, R., Finch, N. A., Baker, M. C., Ghidoni, R., Benussi, L., Binetti, G. G., Rossi, G., Synofzik, M., Wilke, C., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01420-z · Cited by 22 · see citing works

Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology

Zhou, X., Kukar, T. L., & Rademakers, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_14 · Cited by 21 · see citing works

Correction: Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling

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Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease

Zhao, X., Liberti, R., Jian, J., Fu, W., Hettinghouse, A., Sun, Y., & Liu, C.-J. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02127-6 · Cited by 21 · see citing works

GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium – potential biomarkers in the detection of endometriosis – a pilot study

Holzer, I., Weber, A. M., Marshall, A., Freis, A., Jauckus, J., Strowitzki, T., & Germeyer, A. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01905-4 · Cited by 20 · see citing works

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases

Zhao, X., Lin, Y., Liou, B., Fu, W., Jian, J., Fannin, V., Zhang, W., Setchell, K. D. R., Grabowski, G. A., Sun, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210442120 · Cited by 20 · see citing works

PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance

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Elevated serum and urine levels of progranulin (PGRN) as a predictor of microglia activation in the early phase of traumatic brain injury: a further link with the development of neurodegenerative diseases

Olczak, M., Poniatowski, Ł. A., Siwińska, A., Kwiatkowska, M., Chutorański, D., & Wierzba‐Bobrowicz, T. (2021) · Folia Neuropathologica · doi:10.5114/fn.2021.105137 · Cited by 20 · see citing works

Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances

Huang, G., Jian, J., & Liu, C.-J. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.11.001 · Cited by 19 · see citing works

CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia

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Emerging roles of leptin in Parkinson’s disease: Chronic inflammation, neuroprotection and more?

Regensburger, M., Rasul Chaudhry, S., Yasin, H., Zhao, Y., Stadlbauer, A., Buchfelder, M., & Kinfe, T. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.09.010 · Cited by 17 · see citing works

Progranulin and Its Receptor Predict Kidney Function Decline in Patients With Type 2 Diabetes

Murakoshi, M., Gohda, T., Sakuma, H., Shibata, T., Adachi, E., Kishida, C., Ichikawa, S., Koshida, T., Kamei, N., & Suzuki, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.849457 · Cited by 17 · see citing works

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis

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Peroxisomal defects in microglial cells induce a disease-associated microglial signature

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Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study

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SorCS2 binds progranulin to regulate motor neuron development

Thomasen, P. B., Salašová, A., Kjær-Sørensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S. A. D. O., Beel, S., Kavková, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113333 · Cited by 18 · see citing works

Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy

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Single intracerebroventricular progranulin injection adversely affects the blood–brain barrier in experimental traumatic brain injury

Hummel, R., Lang, M., Walderbach, S., Wang, Y., Tegeder, I., Gölz, C., & Schäfer, M. K. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15375 · Cited by 16 · see citing works

Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon

Zambusi, A., Burhan, Ö. P., Giaimo, R. D., Schmid, B., & Ninkovic, J. (2020) · Cells · doi:10.3390/cells9020350 · Cited by 15 · see citing works

Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration

Guha, R., Yue, B., Dong, J., Banerjee, A., & Serrero, G. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06120-y · Cited by 15 · see citing works

Recent advances in the study of progranulin and its role in sepsis

Tian, G., Jin, X., Wang, Q., Ye, T., Li, G., & Liu, J. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106090 · Cited by 14 · see citing works

Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection

Wang, X., Yuan, J., Wang, H., Gan, N., Zhang, Q., Liu, B., Wang, J., Shu, Z., Rao, L., Gou, X., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900248 · Cited by 14 · see citing works

FTD-PSP is an Unusual Clinical Phenotype in A Frontotemporal Dementia Patient with A Novel Progranulin Mutation

Deng, B., Zheng, Z., Zheng, J., Yang, W., Huang, Y., Luo, Y., Jin, D., Shen, L. H., Jin, K., & Wang, Q. (2021) · Aging and Disease · doi:10.14336/ad.2021.0309 · Cited by 13 · see citing works

Association between progranulin serum levels and dietary intake

Nicoletto, B. B., Sarmento, R. A., Pedrollo, E. F., Krolikowski, T. C., & Canani, L. H. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202149 · Cited by 13 · see citing works

Harnessing nerve–muscle cell interactions for biomaterials‐based skeletal muscle regeneration

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The Interplay Between Autophagy and RNA Homeostasis: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Houghton, O. H., Mizielinska, S., & Gómez‐Suaga, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.838402 · Cited by 12 · see citing works

Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases

Kapaki, E. N., Vakrakou, A. G., & Boufidou, F. (2022) · Diagnostics · doi:10.3390/diagnostics13010073 · Cited by 11 · see citing works

Progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders: A preliminary study

Klemm, P., Assmann, G., Preuss, K., Fadle, N., Regitz, E., Martin, T., Pfreundschuh, M., & Thurner, L. (2019) · Immunity Inflammation and Disease · doi:10.1002/iid3.270 · Cited by 11 · see citing works

Fluid Biomarkers of Frontotemporal Lobar Degeneration

van der Ende, E. L., & Swieten, J. C. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_9 · Cited by 10 · see citing works

Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies

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Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study

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Inter-Species Differences in Regulation of the Progranulin–Sortilin Axis in TDP-43 Cell Models of Neurodegeneration

Gumina, V., Onesto, E., Colombrita, C., Maraschi, A., Silani, V., & Ratti, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235866 · Cited by 9 · see citing works

Peripheral immune cell-specific genes in Parkinson’s disease uncovered by multi-omics with therapeutic implications

Hong, Y., Zhou, J., Wang, Y., Song, S., Chen, H., Mi, Y., & Li, X. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01148-z · Cited by 8 · see citing works

Multiple Molecular Pathways Are Influenced by Progranulin in a Neuronal Cell Model–A Parallel Omics Approach

Chitramuthu, B. P., Campos‐García, V. R., & Bateman, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.775391 · Cited by 8 · see citing works

Complexity of progranulin mechanisms of action in mesothelioma

Ventura, E., Xie, C., Buraschi, S., Belfiore, A., Iozzo, R. V., Giordano, A., & Morrione, A. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02546-4 · Cited by 8 · see citing works

Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression

Do, I., Jung, K. U., Koo, D., Lee, Y., Oh, S., Kim, K., Kim, D., Sohn, J. H., Son, B. H., Lee, S. R., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245153 · Cited by 8 · see citing works

Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial

de Souza, J. T., Minicucci, M. F., Ferreira, N. C., Polegato, B. F., Okoshi, M. P., Módolo, G. P., Leal-Pereira, F. W., Phillips, B. E., Atherton, P. J., Smith, K., et al. (2024) · Nutrients · doi:10.3390/nu16234148 · Cited by 7 · see citing works

LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP

Shahidehpour, R. K., Katsumata, Y., Dickson, D. W., Ghayal, N. B., Aung, K. Z., Wu, X., Phe, P., Jicha, G. A., Neltner, A. M., Archer, J. R. C., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02876-5 · Cited by 7 · see citing works

Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children

Wang, F., Chen, T., Sun, L., Lv, H., Li, X., Shen, J., Chen, L., Chu, Z., & Hou, M. (2018) · Disease Markers · doi:10.1155/2018/3729402 · Cited by 7 · see citing works

Development of an In-House EphA2 ELISA for Human Serum and Measurement of Circulating Levels of EphA2 in Hypertensive Patients with Renal Dysfunction

Murakoshi, M., Iwasawa, T., Koshida, T., Suzuki, Y., Gohda, T., & Kato, K. (2022) · Diagnostics · doi:10.3390/diagnostics12123023 · Cited by 7 · see citing works

One novel GRN null mutation, two different aphasia phenotypes

Coppola, C., Oliva, M., Saracino, D., Pappatà, S., Zampella, E., Cimini, S., Ricci, M., Giaccone, G., Iorio, G. D., & Rossi, G. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.008 · Cited by 7 · see citing works

Thymus-Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch

Winkels, H., Ghosheh, Y., Kobiyama, K., Kiosses, W. B., Orecchioni, M., Ehinger, E., Suryawanshi, V., de la Mata, S. H., Marcovecchio, P., Riffelmacher, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100208 · Cited by 6 · see citing works

Progranulin and EGFR modulate receptor-like tyrosine kinase sorting and stability in mesothelioma cells

Ventura, E., Belfiore, A., Iozzo, R. V., Giordano, A., & Morrione, A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00248.2023 · Cited by 6 · see citing works

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

Lin, Y., Zhao, X., Liou, B., Fannin, V., Zhang, W., Setchell, K. D. R., Wang, X., Pan, D., Grabowski, G. A., Liu, C.-J., et al. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae113 · Cited by 6 · see citing works

Folding of Truncated Granulin Peptides

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NEK1 and GRN mutations coexist in a sporadic Chinese Hui descent ALS patient

Zhang, K., Lu, Y., Chen, J., Li, J., Yadav, K. K., Yin, J., & Yang, X. Y. (2020) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1779301 · Cited by 6 · see citing works

Characterization of novel progranulin gene variants in Italian patients with neurodegenerative diseases

Bartoletti‐Stella, A., Pasqua, S. D., Baiardi, S., Bartolomei, I., Mengozzi, G., Orio, G., Pastorelli, F., Piras, S., Poda, R., Raggi, A., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.004 · Cited by 6 · see citing works

Clinical and Molecular Characterization of a Novel Progranulin Deletion Associated with Different Phenotypes

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Potential Fluid Biomarkers and a Prediction Model for Better Recognition Between Multiple System Atrophy-Cerebellar Type and Spinocerebellar Ataxia

Guo, S., Zhao, B., An, Y., Zhang, Y., Meng, Z., Zhou, Y., Zheng, M., Yang, D., Wang, M., & Ying, B. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.644699 · Cited by 5 · see citing works

Structure dissection of zebrafish progranulins identifies a well‐folded granulin/epithelin module protein with pro‐cell survival activities

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Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice

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Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer’s disease

Budda, B., Mitra, A., Park, L., Long, H., Kurnellas, M., Bien‐Ly, N., Estacio, W. F., Burgess, B., Chao, G., Schwabe, T., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01817-4 · Cited by 4 · see citing works

Progranulin: normal function and role in neurodegeneration

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Progranulin

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Progranulin as a therapeutic target in neurodegenerative diseases

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Progranulin in neurodegenerative disease

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