The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Open accessAbstract
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer’s disease, atypical neurodegenerative dementias and Parkinson’s disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.
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1 retracted
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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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Locus coeruleus: a new look at the blue spot
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Blesa, J., Foffani, G., Dehay, B., Bezard, E., & Obeso, J. A. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00542-9 · Cited by 232
Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan
Dahl, M. J., Mather, M., Sander, M. C., & Werkle-Bergner, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0398-19.2020 · Cited by 72
Self-citationAntidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance
Costello, H., Roiser, J. P., & Howard, R. (2023) · Psychological Medicine · doi:10.1017/s003329172200397x · Cited by 60
Self-citationAssociations among locus coeruleus catecholamines, tau pathology, and memory in aging
Ciampa, C. J., Parent, J. H., Harrison, T. M., Fain, R. M., Betts, M. J., Maass, A., Winer, J. R., Baker, S. L., Janabi, M., Furman, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01269-6 · Cited by 54
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Metadata
- Authors
- Betts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., Lambert, C., Cardenas-Blanco, A., Pine, K., Passamonti, L., Loane, C., Keuken, M. C., Trujillo, P., Lüsebrink, F., Mattern, H., Liu, K. Y., Priovoulos, N., Fliessbach, K., Dahl, M. J., Maaß, A., Madelung, C. F., Meder, D., Ehrenberg, A. J., Speck, O., Weiskopf, N., Dolan, R., Inglis, B., Tosun, D., Morawski, M., Zucca, F. A., Siebner, H. R., Mather, M., Uludag, K., Heinsen, H., Poser, B. A., Howard, R., Zecca, L., Rowe, J. B., Grinberg, L. T., Jacobs, H. I. L., Düzel, E., & Hämmerer, D.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07-20
- Volume
- 142
- Issue
- 9
- Pages
- 2558-2571
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2964104722
- Cited by
- 365
- References
- 136
- FWCI
- 28.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Betts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., Lambert, C., Cardenas-Blanco, A., Pine, K., Passamonti, L., Loane, C., Keuken, M. C., Trujillo, P., Lüsebrink, F., Mattern, H., Liu, K. Y., Priovoulos, N., Fliessbach, K., Dahl, M. J., . . . Hämmerer, D. (2019). Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain. https://doi.org/10.1093/brain/awz193
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