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Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
Open accessAbstract
Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We hypothesized that the cognitive impairment in drug-resistant temporal lobe epilepsy could be due to perturbations of amyloid and tau signalling pathways related to activation of stress kinases, similar to those observed in Alzheimer’s disease. We examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). Post-mortem temporal cortex samples from Alzheimer’s disease patients (n = 9) were used as positive controls to validate many of the neurodegeneration-related antibodies. Western blot and immunohistochemical analysis of tissue from temporal lobe epilepsy cases revealed increased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic cleavage product amyloid-β*56. Pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-β1-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. Furthermore, several major stress kinases involved in the development of Alzheimer’s disease pathology were significantly activated in temporal lobe epilepsy brain samples, including the c-Jun N-terminal kinase and the protein kinase R-like endoplasmic reticulum kinase. In temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. Our study suggests that neurodegenerative and stress-related processes common to those observed in Alzheimer’s disease may contribute to cognitive impairment in drug-resistant temporal lobe epilepsy. In particular, we identified several stress pathways that may represent potential novel therapeutic targets.
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“However, the presence of tau pathology in childhood or adolescent-onset epilepsies, such as Dravet syndrome, Nodding syndrome, Lafora disease, NPC, TSC, and ASD, and in relatively younger TLE patient cohorts (Puvenna et al., 2016; Smith et al., 2019; Gourmaud et al., 2020) suggest a causal link between seizure activity and p-tau accumulation.”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Gourmaud et al., 2020
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“and increased total and p-tau levels measured in surgically resected tissue from TLE patients are inversely correlated with cognitive scores (Kandratavicius et al., 2013; Tai et al., 2016; Gourmaud et al., 2020).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Gourmaud et al., 2020
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Metadata
- Authors
- Gourmaud, S., Shou, H., Irwin, D. J., Sansalone, K., Jacobs, L. M., Lucas, T. H., Marsh, E. D., Davis, K. A., Jensen, F. E., & Talos, D. M.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Jensen, Frances E
- Talos, Delia M
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-12-13
- Volume
- 143
- Issue
- 1
- Pages
- 191-209
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC6935754
- OpenAlex
- W2996580238
- Cited by
- 155
- References
- 134
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 30 · 2023: 28 · 2022: 18 · 2021: 21 · 2020: 4
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS101156, R21NS105437, R01NS080565, K23NS088341, K23NS092973)
- University Research Foundation
- Brightfocus Foundation (A2016244S)
- Penn Institute on Aging
- Repository Core for Neurological Disorders, Department of Neurology
- Boston Children’s Hospital
- NIH (P30HD018655)
- Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania
- NIH/National Institute (AG010124)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- temporal lobe epilepsy, drug-resistant epilepsy, cognitive impairment, Alzheimer's disease, tau hyperphosphorylation, stress kinases, c-Jun N-terminal kinase, PERK, BACE1, executive function, hippocampus, temporal cortex, temporal lobectomy, neurodegeneration
- MeSH terms
- Drug Resistant Epilepsy, Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Child, Child, Preschool, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Male, Middle Aged, Peptide Fragments, Temporal Lobe, Case-Control Studies, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Neurosurgical Procedures, eIF-2 Kinase, JNK Mitogen-Activated Protein Kinases, Young Adult, Plaque, Amyloid, Cognitive Dysfunction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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