Cited by 155Alzheimer's disease research and treatmentsEpilepsy research and treatmentDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 133 of the 134 references it cites were found in a registry or an index.

Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.

Open access

Gourmaud, Sarah, Shou, Haochang, Irwin, David J, Sansalone, Kimberly, Jacobs, Leah M, Lucas, Timothy H, Marsh, Eric D, Davis, Kathryn A, Jensen, Frances E, Talos, Delia M·2020·Brain

DOI 10.1093/brain/awz381PMC PMC6935754

Open this paper in CoChat — free account Open PDF

Abstract

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We hypothesized that the cognitive impairment in drug-resistant temporal lobe epilepsy could be due to perturbations of amyloid and tau signalling pathways related to activation of stress kinases, similar to those observed in Alzheimer’s disease. We examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). Post-mortem temporal cortex samples from Alzheimer’s disease patients (n = 9) were used as positive controls to validate many of the neurodegeneration-related antibodies. Western blot and immunohistochemical analysis of tissue from temporal lobe epilepsy cases revealed increased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic cleavage product amyloid-β*56. Pathological phosphorylation of two distinct tau species was also increased in both regions, but increases in amyloid-β1-42 peptide, the main component of amyloid plaques, were restricted to the hippocampus. Furthermore, several major stress kinases involved in the development of Alzheimer’s disease pathology were significantly activated in temporal lobe epilepsy brain samples, including the c-Jun N-terminal kinase and the protein kinase R-like endoplasmic reticulum kinase. In temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impaired preoperative executive function. Our study suggests that neurodegenerative and stress-related processes common to those observed in Alzheimer’s disease may contribute to cognitive impairment in drug-resistant temporal lobe epilepsy. In particular, we identified several stress pathways that may represent potential novel therapeutic targets.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/brain/awz381

Cites

133 of 133 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1×
“The amyloidogenic APP cleavage product amyloid-b 56 accumulates before amyloid-b42 dimers and is associated with memory impairment (Lesne et al., 2006).”
Background
Retracted
RETRACTED: The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
Amar, F., Sherman, M. A., Rush, T., Larson, M. E., Boyle, G. E., Liu, C., Götz, J., Buisson, A., & Lesné, S. (2017) · Science Signaling · doi:10.1126/scisignal.aal2021 · Cited by 114
Retracted
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856
The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1
Blümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Vinters, H. V., Palmini, A., Jacques, T. S., AVANZINI, G., Barkovich, A. J., Battaglia, G. S., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02777.x · Cited by 1,746
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,722
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
The distribution of tau in the mammalian central nervous system.
Binder, L. I., Frankfurter, A., & Rebhun, L. I. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1371 · Cited by 1,588
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
Patrick, G. N., Zukerberg, L. R., Nikolić, M., de la Monte, S. M., Dikkes, P., & Tsai, L. (1999) · Nature · doi:10.1038/45159 · Cited by 1,541
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
Tau pathology in Alzheimer disease and other tauopathies
Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods
Blümcke, I., Thom, M., Aronica, E., Armstrong, D. D., Bartoloméi, F., Bernasconi, A., Bernasconi, N., Bien, C. G., Cendes, F., Coras, R., et al. (2013) · Epilepsia · doi:10.1111/epi.12220 · Cited by 1,010
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
Augustinack, J. C., Schneider, A., Mandelkow, E.-M., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s004010100423 · Cited by 998
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Blümcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C. G., Pfäfflin, M., Elger, C. E., Widman, G., Schramm, J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1703784 · Cited by 935
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881
Alzheimer's disease drug development pipeline: 2018
Cummings, J., Lee, G., Ritter, A., & Zhong, K. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.03.009 · Cited by 697
Epilepsy and Cognitive Impairments in Alzheimer Disease
Palop, J. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.15 · Cited by 684
Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain
Moechars, D., Dewachter, I., Lorent, K., Reversé, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V. D., Checler, F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6483 · Cited by 668
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
Roberson, E. D., Halabisky, B., Yoo, J. W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4152-10.2011 · Cited by 654
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
Moreno, J. A., Radford, H. E., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., Halliday, M., Morgan, J., Dinsdale, D. D., Ortori, C. A., et al. (2012) · Nature · doi:10.1038/nature11058 · Cited by 616
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601
Epileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590
Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease.
Vossel, K. A., Ranasinghe, K. G., Beagle, A. J., Mizuiri, D., Honma, S. M., Dowling, A. F., Darwish, S. M., Van Berlo, V., Barnes, D. E., Mantle, M., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24794 · Cited by 557
Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration
Wang, J., Xia, Y., Grundke, I., & Iqbal, K. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129031 · Cited by 547
A Review of the Epidemiology of Temporal Lobe Epilepsy
Téllez‐Zenteno, J. F., & Hernández‐Ronquillo, L. (2011) · Epilepsy Research and Treatment · doi:10.1155/2012/630853 · Cited by 526
The Mammalian Target of Rapamycin (mTOR) Signaling Pathway Mediates Epileptogenesis in A Model of Temporal Lobe Epilepsy
Zeng, L.-H., Rensing, N., & Wong, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-09.2009 · Cited by 505
APP processing is regulated by cytoplasmic phosphorylation
Lee, M.-S., Kao, S.-C., Lemere, C. A., Xia, W., Tseng, H.-C., Zhou, Y., Neve, R. L., Ahlijanian, M. K., & Tsai, L. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301115 · Cited by 457
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 429
Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration
Bhat, R. V., Shanley, J. R., Correll, M. P., Fieles, W. E., Keith, R. A., Scott, C. W., & Lee, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190297597 · Cited by 379
Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease
Lam, A. D., Deck, G. M., Goldman, A. M., Eskandar, E. N., Noebels, J. L., & Cole, A. J. (2017) · Nature Medicine · doi:10.1038/nm.4330 · Cited by 369
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
Caccamo, A., Magrì, A., Medina, D. X., Wisely, E. V., López‐Aranda, M. F., Silva, A. J., & Oddo, S. (2013) · Aging Cell · doi:10.1111/acel.12057 · Cited by 362
Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy
Gelinas, J. N., Khodagholy, D., Thesen, T., Devinsky, O., & Buzsáki, G. (2016) · Nature Medicine · doi:10.1038/nm.4084 · Cited by 348
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Appenzeller‐Herzog, C., & Hall, M. N. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.02.006 · Cited by 324
Antisense Reduction of Tau in Adult Mice Protects against Seizures
DeVos, S. L., Goncharoff, D. K., Chen, G., Kebodeaux, C. S., Yamada, K., Stewart, F. R., Schuler, D. R., Maloney, S. E., Wozniak, D. F., Rigo, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-13.2013 · Cited by 311
Cognitive prognosis in chronic temporal lobe epilepsy
Hermann, B. P., Seidenberg, M., Dow, C., Jones, J. E., Rutecki, P. A., Bhattacharya, A., & Bell, B. D. (2006) · Annals of Neurology · doi:10.1002/ana.20872 · Cited by 299
FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Westmark, C. J., & Malter, J. S. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050052 · Cited by 296
Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections.
Tai, X. Y., Koepp, M., Duncan, J. S., Fox, N., Thompson, P., Baxendale, S., Liu, J. Y. W., Reeves, C., Michalak, Z., & Thom, M. (2016) · Brain · doi:10.1093/brain/aww187 · Cited by 291
Hippocampal interictal epileptiform activity disrupts cognition in humans
Kleen, J. K., Scott, R. C., Holmes, G. L., Roberts, D. W., Rundle, M. M., Testorf, M. E., Lenck‐Santini, P., & Jobst, B. C. (2013) · Neurology · doi:10.1212/wnl.0b013e318297ee50 · Cited by 276
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., & Terro, F. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.008 · Cited by 265
A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation
Noebels, J. L. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02909.x · Cited by 261
Both total and phosphorylated tau are increased in Alzheimer's disease
Sjögren, M. J. C. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.5.624 · Cited by 253
Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes
Berg, A. T., Zelko, F. A. J., Levy, S. R., & Testa, F. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826c1b55 · Cited by 249
Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy
Buckmaster, P., Ingram, E. A., & Wen, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4179-08.2009 · Cited by 239
Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy
Holth, J. K., Bomben, V. C., Reed, J. G., Inoue, T., Younkin, L., Younkin, S. G., Pautler, R. G., Botas, J., & Noebels, J. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3191-12.2013 · Cited by 238
Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5
Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Kirino, Y., Nairn, A. C., & Suzuki, T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751085.x · Cited by 234
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
Huang, X., Zhang, H., Yang, J., Wu, J., McMahon, J. J., Lin, Y., Cao, Z., Gruenthal, M., & Huang, Y. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.024 · Cited by 231
Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease
Kirouac, L., Rajic, A. J., Cribbs, D. H., & Padmanabhan, J. (2017) · eneuro · doi:10.1523/eneuro.0149-16.2017 · Cited by 207
Activation of the Unfolded Protein Response Is an Early Event in Alzheimer’s and Parkinson’s Disease
Hoozemans, J. J. M., van Haastert, E. S., Nijholt, D. A. T., Rozemüller, A. J. M., & Scheper, W. (2012) · Neurodegenerative Diseases · doi:10.1159/000334536 · Cited by 202
Patients with epilepsy: Cognitively compromised before the start of antiepileptic drug treatment?
Taylor, J., Kolamunnage‐Dona, R., Marson, A. G., Smith, P. E. M., Aldenkamp, A. P., Baker, G. A., & on behalf of the SANAD study group (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02195.x · Cited by 202
In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase‐3β
Aplin, A. E., Gibb, G. M., Jacobsen, J. S., Gallo, J., & Anderton, B. H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020699.x · Cited by 201
Increased Neuronal β‐Amyloid Precursor Protein Expression in Human Temporal Lobe Epilepsy: Association with Interleukin‐1α Immunoreactivity
Sheng, J. G., Boop, F. A., Mrak, R. E., & Griffin, W. S. T. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63051872.x · Cited by 201
Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States
Asadi‐Pooya, A. A., Stewart, G. R., Abrams, D. J., & Sharan, A. D. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.12.074 · Cited by 199
Caspase-2 cleavage of tau reversibly impairs memory
Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. H. (2016) · Nature Medicine · doi:10.1038/nm.4199 · Cited by 187
Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures
Rakhade, S. N., Zhou, C., Aujla, P. K., Fishman, R. E., Sucher, N. J., & Jensen, F. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1734-08.2008 · Cited by 182
Self-citation
The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway
Talos, D. M., Sun, H., Zhou, X., Fitzgerald, E. C., Jackson, M. C., Klein, P., Lan, V. J., Joseph, A., & Jensen, F. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035885 · Cited by 182
Self-citation
Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
Born, H. A., Kim, J.-Y., Savjani, R. R., Das, P., Dabaghian, Y. A., Guo, Q., Yoo, J. W., Schuler, D. R., Cirrito, J. R., Zheng, H., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5171-13.2014 · Cited by 178
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
Goto, J., Talos, D. M., Klein, P., Qin, W., Chekaluk, Y. I., Anderl, S., Malinowska, I. A., Nardo, A. D., Bronson, R. T., Chan, J. A.-W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106454108 · Cited by 176
Self-citation
Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood–brain barrier leakage but not microglia activation
van Vliet, E. A., Forte, G., Holtman, L., den Burger, J. C. G., Sinjewel, A., de Vries, H. E., Aronica, E., & Gorter, J. A. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03513.x · Cited by 176
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model
Schoch, K. M., DeVos, S. L., Miller, R. L., Chun, S. J., Norrbom, M., Wozniak, D. F., Dawson, H. N., Bennett, C. F., Rigo, F., & Miller, T. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.042 · Cited by 175
Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
Hamani, C., Florence, G., Heinsen, H., Plantinga, B. R., Temel, Y., Uludaǧ, K., Alho, E. J. L., Teixeira, M. J., Amaro, E., & Fonoff, E. T. (2017) · eNeuro · doi:10.1523/eneuro.0140-17.2017 · Cited by 173
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
Devi, L., & Ohno, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.031 · Cited by 169
Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients
Witt, J., & Helmstaedter, C. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6526-2 · Cited by 168
Senile plaques in temporal lobe epilepsy
Mackenzie, I. R. A., & Miller, L. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00294177 · Cited by 168
Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study.
Thom, M., Liu, J. Y. W., Thompson, P., Phadke, R., Narkiewicz, M., Martinian, L., Marsdon, D., Koepp, M., Caboclo, L., Catarino, C. B., et al. (2011) · Brain · doi:10.1093/brain/awr209 · Cited by 167
Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner
Di Nardo, A., Kramvis, I., Cho, N., Sadowski, A., Meikle, L., Kwiatkowski, D. J., & Sahin, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0778-09.2009 · Cited by 165
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Youmans, K. L., Tai, L. M., Kanekiyo, T., Stine Jr, W. B., Michon, S.-C., Nwabuisi-Heath, E., Manelli, A. M., Fu, Y., Riordan, S., Eimer, W. A., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-8 · Cited by 164
Decreased Expression and Activity of Neprilysin in Alzheimer Disease Are Associated With Cerebral Amyloid Angiopathy
Miners, J. S., Helmond, Z. V., Chalmers, K. A., Wilcock, G. K., Love, S., & Kehoe, P. G. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240463.87886.9a · Cited by 156
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
Braak, H., Zetterberg, H., Tredici, K. D., & Blennow, K. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1139-0 · Cited by 148
Interictal epileptiform activity outside the seizure onset zone impacts cognition
Ung, H., Cazares, C., Nanivadekar, A. C., Kini, L. G., Wagenaar, J., Becker, D. A., Krieger, A. Μ., Lucas, T. H., Litt, B., & Davis, K. A. (2017) · Brain · doi:10.1093/brain/awx143 · Cited by 148
Self-citation
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy
Puvenna, V., Engeler, M., Banjara, M., Brennan, C., Schreiber, P., Dadas, A., Bahrami, A., Solanki, J., Bandyopadhyay, A., Morris, J. K., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.007 · Cited by 144
Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience
Jensen, F. E. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2010.02904.x · Cited by 142
Self-citation
Seizures in Alzheimer’s disease
Born, H. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.051 · Cited by 139
Tau reduction prevents disease in a mouse model of Dravet syndrome
Gheyara, A. L., Ponnusamy, R., Djukic, B., Craft, R. J., Ho, K., Guo, W., Finucane, M. M., Sanchez, P. E., & Mucke, L. (2014) · Annals of Neurology · doi:10.1002/ana.24230 · Cited by 138
Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11.
Hilbich, C., Mönning, U., Grund, C., Masters, C. L., & Beyreuther, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74350-6 · Cited by 137
Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines
Lee, K. J., Moussa, C., Lee, Y. J., Sung, Y., Howell, B. W., Turner, R. S., Pak, D. T. S., & Hoe, H.-S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.078 · Cited by 133
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Liu, S.-J., Zheng, P., Wright, D. K., Dezsi, G., Braine, E., Nguyen, T., Corcoran, N. M., Johnston, L. A., Hovens, C. M., Mayo, J. N., et al. (2016) · Brain · doi:10.1093/brain/aww116 · Cited by 127
Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms
Chin, J., & Scharfman, H. E. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.11.040 · Cited by 126
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 121
Phosphorylation of thr668in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress‐activated protein kinase 1b (Jun N‐terminal kinase‐3)
Standen, C. L., Brownlees, J., Grierson, A. J., Kesavapany, S., Lau, K., McLoughlin, D. M., & Miller, C. C. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00102.x · Cited by 121
Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss
Di, J., Cohen, L. S., Corbo, C. P., Phillips, G. R., Idrissi, A. E., & Alonso, A. D. C. (2016) · Scientific Reports · doi:10.1038/srep20833 · Cited by 120
Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease
Sun, Y.-X., Ji, X., Mao, X., Xie, L., Jia, J., Galván, V., Greenberg, D. A., & Jin, K. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131124 · Cited by 119
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen
Lalonde, R., Dumont, M., Staufenbiel, M., & Strazielle, C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.020 · Cited by 118
Seizure susceptibility and mortality in mice that over-express amyloid precursor protein.
Westmark, C. J., Westmark, P. R., Beard, A. M., Hildebrandt, S. M., & Malter, J. S. (2008) · PubMed Central · Cited by 116
Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
Yan, R. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00097 · Cited by 115
The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity
Hoe, H., Fu, Z., Makarova, A., Lee, J.-Y., Lu, C., Feng, L., Pajoohesh‐Ganji, A., Matsuoka, Y., Hyman, B. T., Ehlers, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900141200 · Cited by 114
Structural brain changes in medically refractory focal epilepsy resemble premature brain aging
Pardoe, H., Cole, J. H., Blackmon, K., Thesen, T., & Kuzniecky, R. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.03.007 · Cited by 114
mTor mediates tau localization and secretion: implication for Alzheimer’s disease
Tang, Z., Ioja, E., Bereczki, E., Hultenby, K., Li, C., Guan, Z., Winblad, B., & Pei, J.-J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.003 · Cited by 112
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova, S., Gurevicius, K., Kutchiashvili, N., Bolkvadze, T., Nissinen, J., Tanila, H., & Pitkänen, A. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.01.003 · Cited by 106
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
Caccamo, A., Branca, C., Talboom, J. S., Shaw, D. M., Turner, D., Ma, L., Messina, A. A., Huang, Z., Wu, J., & Oddo, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-15.2015 · Cited by 105
Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline
Gourmaud, S., Paquet, C., Dumurgier, J., Pace, C., Bouras, C., Gray, F., Laplanche, J., MEURS, E. F., Mouton‐Liger, F., & Hugon, J. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140062 · Cited by 95
Self-citation
Enfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2015) · Neurología · doi:10.1016/j.nrl.2015.08.002 · Cited by 86
Amyloid Clearance as a Treatment Target Against Alzheimer's Disease
Kurz, A., & Perneczky, R. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102139 · Cited by 84
Endoplasmic Reticulum Stress and Apoptosis Signaling in Human Temporal Lobe Epilepsy
Yamamoto, A., Murphy, N., Schindler, C. K., So, N. K., Stöhr, S., Taki, W., Prehn, J. H. M., & Henshall, D. C. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000202886.22082.2a · Cited by 82
Kainate induces AKT, ERK and cdk5/GSK3β pathway deregulation, phosphorylates tau protein in mouse hippocampus
Crespo‐Biel, N., Canudas, A. M., Camins, A., & Pallàs, M. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.10.002 · Cited by 82
Early- and late-onset Alzheimer disease: Are they the same entity?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.08.009 · Cited by 81
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Jones, N. C., Nguyen, T., Corcoran, N. M., Velakoulis, D., Chen, T., Grundy, R., O'Brien, T. J., & Hovens, C. M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.005 · Cited by 81
AMPA Receptor antagonist NBQX attenuates later‐life epileptic seizures and autistic‐like social deficits following neonatal seizures
Bell, J. J. L., Rakhade, S. N., Klein, P., Obeid, M., Jackson, M. C., Joseph, A., & Jensen, F. E. (2013) · Epilepsia · doi:10.1111/epi.12378 · Cited by 79
Self-citation
Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later
Joutsa, J., Rinne, J. O., Hermann, B. P., Karrasch, M., Anttinen, A., Shinnar, S., & Sillanpää, M. L. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6091 · Cited by 79
Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy
Talos, D. M., Jacobs, L., Gourmaud, S., Coto, C. A., Sun, H., Lim, K., Lucas, T. H., Davis, K. A., Martinez‐Lage, M., & Jensen, F. E. (2018) · Annals of Neurology · doi:10.1002/ana.25149 · Cited by 76
Self-citation
Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage.
Liang, Z., Liu, F., Iqbal, K., Grundke-Iqbal, I., & Gong, C.-X. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1069 · Cited by 73
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome
Pasciuto, E., Ahmed, T., Wahle, T., Gardoni, F., D’Andrea, L., Pacini, L., Jacquemont, S., Tassone, F., Balschun, D., Dotti, C. G., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.032 · Cited by 71
Seizure resistance without parkinsonism in aged mice after tau reduction
Li, Z., Hall, A. M., Kelinske, M., & Roberson, E. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.001 · Cited by 71
Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy
Espíndola, S. L., Damianich, A., Alvarez, R. J., Sartor, M., Belforte, J. E., Ferrario, J. E., Gallo, J.-M., & Avale, M. E. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.079 · Cited by 65
Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice
Yan, X.-X., Cai, Y., Shelton, J., Deng, S.-H., Luo, X.-G., Oddo, S., LaFerla, F. M., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048782 · Cited by 64
Temporal lobe epilepsy is associated with distinct cognitive phenotypes
Elverman, K. H., Resch, Z. J., Quasney, E. E., Sabsevitz, D. S., Binder, J. R., & Swanson, S. J. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.015 · Cited by 64
What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders
Westmark, C. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.122 · Cited by 63
mTOR is the rapamycin‐sensitive kinase that confers mechanically‐induced phosphorylation of the hydrophobic motif site Thr(389) in p70S6k
Hornberger, T. A., Sukhija, K. B., Wang, X.-R., & Chien, S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.045 · Cited by 63
c‐Jun N‐terminal kinase signaling pathway in excitotoxic cell death following kainic acid‐induced status epilepticus
Spigolon, G., Veronesi, C., Bonny, C., & Vercelli, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07158.x · Cited by 62
Brain structure and aging in chronic temporal lobe epilepsy
Dabbs, K., Becker, T., Jones, J. E., Rutecki, P. A., Seidenberg, M., & Hermann, B. P. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03447.x · Cited by 62
In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice
Morales‐Corraliza, J., Mazzella, M. J., Berger, J. D., Diaz, N. S., Choi, J. H. K., Levy, E., Matsuoka, Y., Planel, E., & Mathews, P. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007134 · Cited by 60
Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus
Torres-Peraza, J. F., Engel, T., Martín‐Ibáñez, R., Sanz‐Rodriguez, A., Fernández-Fernández, M. R., Esgleas, M., Canals, J. M., Henshall, D. C., & Lucas, J. J. (2013) · Brain · doi:10.1093/brain/awt044 · Cited by 58
Effect of epileptic seizures on the cerebrospinal fluid–A systematic retrospective analysis.
Tumani, H., Jobs, C., Brettschneider, J., Hoppner, A. C., Kerling, F., & Fauser, S. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.04.004 · Cited by 57
Cell injury and Premature Neurodegeneration in Focal Malformations of Cortical Development
Iyer, A. M., Prabowo, A. S., Anink, J. J., Spliet, W. G. M., van Rijen, P. C., & Aronica, E. (2013) · Brain Pathology · doi:10.1111/bpa.12060 · Cited by 56
Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology
Hara, M., Hirokawa, K., Kamei, S., & Uchihara, T. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1097-6 · Cited by 55
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia
Perez, S. E., Miguel, J. C., He, B., Malek‐Ahmadi, M. H., Abrahamson, E. E., Ikonomović, M. D., Lott, I. T., Doran, E. W., Alldred, M. J., Ginsberg, S. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01965-6 · Cited by 48
Transcriptional and post‐transcriptional regulation of β‐secretase
Tamagno, E., Guglielmotto, M., Monteleone, D., Vercelli, A., & Tabaton, M. (2012) · IUBMB Life · doi:10.1002/iub.1099 · Cited by 40
Expression of β-amyloid precursor protein in refractory epilepsy
Sima, X., Xu, J., Li, J., Zhong, W., & You, C. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1977 · Cited by 37
Expression of neurodegenerative disease‐related proteins and caspase‐3 in glioneuronal tumours
Prabowo, A. S., Iyer, A. M., Veersema, T. J., Anink, J. J., Meeteren, A. Y. N. S., Spliet, W. G. M., van Rijen, P. C., Ferrier, C. H., Thom, M., & Aronica, E. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12143 · Cited by 36
Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy
Liu, G., Guo, H., Guo, C., Zhao, S., Gong, D., & Zhao, Y. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.10.004 · Cited by 35
Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy
Tai, T. Y., Warner, L. N., Jones, T. D., Jung, S., Concepcion, F. A., Skyrud, D. W., Fender, J. S., Liu, Y. K., Williams, A. D., Neumaier, J. F., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.024 · Cited by 35
Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model.
Tian, F., Zeng, C., Ma, Y., Guo, T.-H., Chen, J.-M., Chen, Y., Cai, X., Li, F.-R., Wang, X., Huang, W., et al. (2010) · PubMed · Cited by 34
Phosphorylation of the α subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus
Carnevalli, L. S., Pereira, M. G., Jaqueta, C. B., Alves, V. S., Paiva, V. N., Vattem, K. M., Wek, R. C., Mello, L. E., & Castilho, B. A. (2006) · Biochemical Journal · doi:10.1042/bj20051643 · Cited by 30
A role for astrocyte‐derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy
Kodam, A., Ourdev, D., Maulik, M., Hariharakrishnan, J., Banerjee, M., Yu⁃xiang, W. A. N. G., & Kar, S. (2018) · Brain Pathology · doi:10.1111/bpa.12617 · Cited by 27
APP Causes Hyperexcitability in Fragile X Mice
Westmark, C. J., Chuang, S.-C., Hays, S. A., Filon, M. J., Ray, B. C., Westmark, P. R., Gibson, J. R., Huber, K. M., & Wong, R. K. S. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00147 · Cited by 24
How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery?
Hernández‐Ronquillo, L., Buckley, S., Ladino, L. D., Wu, A., Moien‐Afshari, F., Rizvi, S., & Tellez-Zenteno, J. F. (2016) · Epileptic Disorders · doi:10.1684/epd.2016.0822 · Cited by 22
Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61Substrates Involved in Hippocampal Synaptic Plasticity
Jang, S.-S., Royston, S. E., Lee, G., Wang, S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/2123748 · Cited by 21
The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats
Chen, X., Wu, J., Hua, D., Shu, K., Wang, J., Li, L., & Lei, T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.082 · Cited by 17
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
Croft, C. L., Moore, B. D., Ran, Y., Chakrabarty, P., Levites, Y., Golde, T. E., & Giasson, B. I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195211 · Cited by 16
A bidirectional association between cognitive ability in young adulthood and epilepsy: a population-based cohort study
Osler, M., Mortensen, E. L., Christensen, K., & Christensen, G. T. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy018 · Cited by 15
Role of Endoplasmic Reticulum Stress via the PERK Signaling Pathway in Brain Injury from Status Epilepticus
Chen, J., Zheng, G., Guo, H., & Shi, Z.-N. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0236-4 · Cited by 13

Flagged first, then by citations

1 of the 134 references couldn’t be matched to a known paper.

Sorted by citations

Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy
Hermann, B. P., Struck, A. F., Busch, R. M., Reyes, A., Kaestner, E. J., & McDonald, C. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00555-z · Cited by 153
Amyloid-β: a potential link between epilepsy and cognitive decline
Romoli, M., Sen, A., Parnetti, L., Calabresi, P., & Costa, C. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00505-9 · Cited by 133
The aetiologies of epilepsy
Balestrini, S., Arzimanoglou, A. A., Blümcke, I., Scheffer, I. E., Wiebe, S., Zelano, J., & Walker, M. C. (2021) · Epileptic Disorders · doi:10.1684/epd.2021.1255 · Cited by 131
Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
Kamondi, A., Grigg-Damberger, M. M., Löscher, W., Tanila, H., & Horvath, A. A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00932-4 · Cited by 104
Neurovascular unit dysfunction as a mechanism of seizures and epilepsy during aging
van Vliet, E. A., & Marchi, N. (2022) · Epilepsia · doi:10.1111/epi.17210 · Cited by 69

See all 155

Authors: Gourmaud, S., Shou, H., Irwin, D. J., Sansalone, K., Jacobs, L. M., Lucas, T. H., Marsh, E. D., Davis, K. A., Jensen, F. E., & Talos, D. M.
Affiliations: University of Pennsylvania (US)
Children's Hospital of Philadelphia (US)
Corresponding author: Jensen, Frances E
Talos, Delia M
ORCID: Gourmaud, Sarah
Shou, Haochang
Irwin, David J
Marsh, Eric D
Davis, Kathryn A
Jensen, Frances E
Talos, Delia M
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2019-12-13
Volume: 143
Issue: 1
Pages: 191-209
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awz381
PMC: PMC6935754
OpenAlex: W2996580238
Cited by: 155
References: 134
Citations by year: 2026: 20 · 2025: 33 · 2024: 30 · 2023: 28 · 2022: 18 · 2021: 21 · 2020: 4
FWCI: 7.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Brain (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS101156, R21NS105437, R01NS080565, K23NS088341, K23NS092973)
University Research Foundation
Brightfocus Foundation (A2016244S)
Penn Institute on Aging
Repository Core for Neurological Disorders, Department of Neurology
Boston Children’s Hospital
NIH (P30HD018655)
Center for Neurodegenerative Disease Research (CNDR) at the University of Pennsylvania
NIH/National Institute (AG010124)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: temporal lobe epilepsy, drug-resistant epilepsy, cognitive impairment, Alzheimer's disease, tau hyperphosphorylation, stress kinases, c-Jun N-terminal kinase, PERK, BACE1, executive function, hippocampus, temporal cortex, temporal lobectomy, neurodegeneration
MeSH terms: Drug Resistant Epilepsy, Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Child, Child, Preschool, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Male, Middle Aged, Peptide Fragments, Temporal Lobe, Case-Control Studies, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Neurosurgical Procedures, eIF-2 Kinase, JNK Mitogen-Activated Protein Kinases, Young Adult, Plaque, Amyloid, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks