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18F-fluorodeoxyglucose positron emission tomography in dementia with Lewy bodies
Open accessAbstract
Among individuals with dementia with Lewy bodies, pathologic correlates of clinical course include the presence and extent of coexisting Alzheimer’s pathology and the presence of transitional or diffuse Lewy body disease. The objectives of this study are to determine (i) whether 18F-fluorodeoxyglucose PET signature patterns of dementia with Lewy bodies are associated with the extent of coexisting Alzheimer’s pathology and the presence of transitional or diffuse Lewy body disease and (ii) whether these 18F-fluorodeoxyglucose pattern(s) are associated with clinical course in dementia with Lewy bodies. Two groups of participants were included: a pathology-confirmed subset with Lewy body disease (n = 34) and a clinically diagnosed group of dementia with Lewy bodies (n = 87). A subset of the clinically diagnosed group was followed longitudinally (n = 51). We evaluated whether 18F-fluorodeoxyglucose PET features of dementia with Lewy bodies (higher cingulate island sign ratio and greater occipital hypometabolism) varied by Lewy body disease subtype (transitional versus diffuse) and Braak neurofibrillary tangle stage. We investigated whether the PET features were associated with the clinical trajectories by performing regression models predicting Clinical Dementia Rating Scale Sum of Boxes. Among autopsied participants, there was no difference in cingulate island sign or occipital hypometabolism by Lewy body disease type, but those with a lower Braak tangle stage had a higher cingulate island sign ratio compared to those with a higher Braak tangle stage. Among the clinically diagnosed dementia with Lewy bodies participants, a higher cingulate island ratio was associated with better cognitive scores at baseline and longitudinally. A higher 18F-fluorodeoxyglucose PET cingulate island sign ratio was associated with lower Braak tangle stage at autopsy, predicted a better clinical trajectory in dementia with Lewy body patients and may allow for improved prognostication of the clinical course in this disease.
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“Scans from DLB patients with presence of co-existing AD pathology are much less likely to show the cingulate island sign [123].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [123]
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Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Dementia with Lewy bodies: Basis of cingulate island sign
Graff-Radford, J., Murray, M. E., Lowe, V. J., Boeve, B. F., Ferman, T. J., Przybelski, S. A., Lesnick, T. G., Senjem, M. L., Gunter, J. L., Smith, G. E., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000734 · Cited by 163
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Research works printed but not linked: 25
- Avants, 2011, A reproducible evaluation of ANTs similarity metric performance in brain image registration, NeuroImage, 54, 2033, 10.1016/j.neuroimage.2010.09.025 · DOI · Paper page
- Berg, 1988, Mild senile dementia of the Alzheimer type: 2. Longitudinal assessment, Ann Neurol, 23, 477, 10.1002/ana.410230509 · DOI
- Boeve, 2011, Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort, Sleep Med, 12, 445, 10.1016/j.sleep.2010.12.009 · DOI
- Coughlin, 2018, Cognitive and pathological influences of tau pathology in Lewy body disorders, Ann Neurol, 85, 259, 10.1002/ana.25392 · DOI
- Ferman, 2004, DLB fluctuations, Specific features that reliably differentiate DLB from AD and normal aging. Neurology, 62, 181
- Fujishiro, 2008, Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases, J Neuropathol Exp Neurol, 67, 649, 10.1097/NEN.0b013e31817d7a1d · DOI
- Graff-Radford, 2017, Duration and pathologic correlates of Lewy body disease, JAMA Neurol, 74, 310, 10.1001/jamaneurol.2016.4926 · DOI
- Graff-Radford, 2012, Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies, Brain, 135, 2470, 10.1093/brain/aws173 · DOI
- Graff-Radford, 2016, Predicting survival in dementia with Lewy bodies with hippocampal volumetry, Mov Disord, 31, 989, 10.1002/mds.26666 · DOI
- Hyman, 2012, National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease, Alzheimers Dement, 8, 1, 10.1016/j.jalz.2011.10.007 · DOI · Paper page
- Iizuka, 2016, Cingulate island sign on FDG-PET is associated with medial temporal lobe atrophy in dementia with Lewy bodies, Ann Nucl Med, 30, 421, 10.1007/s12149-016-1076-9 · DOI
- Imabayashi, 2017, Validation of the cingulate island sign with optimized ratios for discriminating dementia with Lewy bodies from Alzheimer’s disease using brain perfusion SPECT, Ann Nucl Med, 31, 536, 10.1007/s12149-017-1181-4 · DOI
- Irwin, 2017, Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis, Lancet Neurol, 16, 55, 10.1016/S1474-4422(16)30291-5 · DOI
- Kantarci, 2012, Multimodality imaging characteristics of dementia with Lewy bodies, Neurobiol Aging, 33, 2091, 10.1016/j.neurobiolaging.2011.09.024 · DOI
- Lemstra, 2017, Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies, J Neurol Neurosurg Psychiatry, 88, 113, 10.1136/jnnp-2016-313775 · DOI
- Lim, 2009, The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. Journal of nuclear medicine: official publication, Soc Nucl Med, 50, 1638, 10.2967/jnumed.109.065870 · DOI · Paper page
- McKeith, 2017, Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium, Neurology, 89, 88, 10.1212/WNL.0000000000004058 · DOI · Paper page
- Mirra, 1991, The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Part II standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology, 41, 479
- Morris, 1993, The Clinical Dementia Rating (CDR): current version and scoring rules, Neurology, 43, 2412, 10.1212/WNL.43.11.2412-a · DOI · Paper page
- Olichney, 1998, Cognitive decline is faster in Lewy body variant than in Alzheimer’s disease, Neurology, 51, 351, 10.1212/WNL.51.2.351 · DOI
- Patterson, 2019, Neuropathological changes in dementia with Lewy bodies and the cingulate island sign, J Neuropathol Exp Neurol, 78, 717, 10.1093/jnen/nlz047 · DOI
- Rongve, 2014, Time until nursing home admission in people with mild dementia: comparison of dementia with Lewy bodies and Alzheimer’s dementia, Int J Geriatr Psychiatry, 29, 392, 10.1002/gps.4015 · DOI
- Schwarz, 2017, The mayo clinic adult lifespan template: better quantification across the lifespan, Alzheimers Dement, 13, P792, 10.1016/j.jalz.2017.06.1071 · DOI
- Tzourio-Mazoyer, 2002, Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain, NeuroImage, 15, 273, 10.1006/nimg.2001.0978 · DOI · Paper page
- Williams, 2006, Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease, Neurology, 67, 1935, 10.1212/01.wnl.0000247041.63081.98 · DOI · Paper page
Cited by
Sorted by citations
The use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 221
Metadata
- Authors
- Graff-Radford, J., Lesnick, T. G., Savica, R., Chen, Q., Ferman, T. J., Przybelski, S. A., Jones, D. T., Senjem, M. L., Gunter, J. L., Kremers, W. K., Jack, C. R., Lowe, V. J., Petersen, R. C., Knopman, D. S., Boeve, B. F., Murray, M. E., Dickson, D. W., & Kantarci, K.
- Affiliations
- Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- ORCID
- Venue
- Brain Communications
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-01-01
- Volume
- 2
- Issue
- 1
- Pages
- fcaa040-fcaa040
- ISSN
- 2632-1297 (ISSN-L)
- PMC
- PMC7293797
- OpenAlex
- W3015874802
- Cited by
- 28
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 5
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Communications (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (C06-RR018898)
- National Institute on Aging (R01-AG050603, P50-AG016574, U01-AG006786)
- Mangurian Foundation for Lewy Body Research
- Elsie and Marvin Dekelboum Family Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- dementia with Lewy bodies, 18F-FDG PET, Alzheimer's disease pathology, clinical course, outcome prediction, Clinical Dementia Rating
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