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In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids
Abstract
Recent in vivo studies in humans have shown a dramatic effect of grapefruit juice in blocking the oxidation of dihydropyridine calcium channel blockers. The flavonoid naringin is the most abundant natural product specific for grapefruit and related citrus--the aglycone naringenin, known to be readily formed from naringin in humans, was found to inhibit the oxidation of the dihydropyridines nifedipine and felodipine in human liver microsomal preparations. These observations were of interest in light of the knowledge that the same human liver cytochrome P450 (IIIA4) appears to be a major catalyst in both nifedipine oxidation and aflatoxin B1 activation. Several flavones inhibited the in vitro activation of aflatoxin B1 in a system employing umuC gene activation due to DNA damage in Salmonella typhimurium TA1535/pSK1002, with naringenin being as effective as any. The high concentration of derivatives of naringenin in certain citrus fruits may be of relevance to cancer chemoprevention involving those carcinogens that are activated by cytochrome P-450IIIA4.
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Cited by
Mechanism of the Cardiotoxic Actions of Terfenadine
Woosley, R. L. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500120070028 · Cited by 646
Flavonoids: Dietary occurrence and biochemical activity
Peterson, J., & Dwyer, J. (1998) · Nutrition Research · doi:10.1016/s0271-5317(98)00169-9 · Cited by 608
Cavia‐Saiz, M., Busto, M. D., Pilar‐Izquierdo, M. C., Ortega, N., Perez‐Mateos, M., & Muñiz, P. (2010) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3959 · Cited by 441
Qi, W., Qi, W., Xiong, D., & Long, M. (2022) · Molecules · doi:10.3390/molecules27196545 · Cited by 365
Effects of Food on Clinical Pharmacokinetics
Singh, B. N. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199937030-00003 · Cited by 364
Metadata
- Authors
- Peter, F., & Kim, D.-H.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1990
- Volume
- 11
- Issue
- 12
- Pages
- 2275-2279
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2130124282
- Cited by
- 245
- References
- 0
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. https://app.cochat.ai/papers/10.1093/carcin/11.12.2275
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- Peter, F., & Kim, D.-H. (1990). In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis. https://doi.org/10.1093/carcin/11.12.2275
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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