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Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide
Abstract
Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice and rats following i.p. administration of 14C-labeled acrylamide. A major adduct found in both species was N-7-(2-carbamoyl-2-hydroxy-ethyl)guanine, formed by reaction of the DNA with the epoxide metabolite glycidamide. The levels of this adduct were similar in the different organs of the two rodent species, which supports the notion that glycidamide is relatively evenly distributed among tissues and that the organ-specificity in acrylamide carcinogenesis cannot be explained by a selective accumulation of the DNA-reactive metabolite in target organs.
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Citations
Cited by
Scientific Opinion on acrylamide in food
(CONTAM), E. P. O. C. I. T. F. C. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4104 · Cited by 828
Acrylamide: A Cooking Carcinogen?
Tareke, E., Rydberg, P., Karlsson, P., Eriksson, S., & Törnqvist, M. (2000) · Chemical Research in Toxicology · doi:10.1021/tx9901938 · Cited by 543
Human exposure and internal dose assessments of acrylamide in food
Dybing, E., Farmer, P. B., Andersen, M., Fennell, T. R., Lalljie, S. P. D., Müller, D. J. G., Olin, S., Petersen, B. J., Schlatter, J., Scholz, G., et al. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.11.004 · Cited by 395
Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications
Törnqvist, M., Fred, C., Haglund, J., Helleberg, H., Paulsson, B., & Rydberg, P. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00172-1 · Cited by 332
The Carcinogenicity of Acrylamide
Rice, J. M. (2005) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2004.09.008 · Cited by 329
Metadata
- Authors
- Segerbäck, D., Calleman, C. J., Schroeder, J. L., Costa, L. G., & Faustman, E. M.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1995
- Volume
- 16
- Issue
- 5
- Pages
- 1161-1165
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2005740946
- Cited by
- 230
- References
- 0
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. https://app.cochat.ai/papers/10.1093/carcin/16.5.1161
- The paper
- Segerbäck, D., Calleman, C. J., Schroeder, J. L., Costa, L. G., & Faustman, E. M. (1995). Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Carcinogenesis. https://doi.org/10.1093/carcin/16.5.1161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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