The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos
Abstract
Crocidolite asbestos is associated with the development of mesothelioma. Although chromosomal changes have been documented in mesothelial cells, the mechanisms of interaction of crocidolite with DNA remain obscure. Since human mesothelial cells are exquisitely sensitive to asbestos, oxidative DNA damage was measured in an asbestos-exposed human mesothelial cell line (MET5A) by assaying oxidized guanine bases [8-oxo-2'-deoxyguanosine (oxo8dG), 8-oxoguanine (oxo8G), and 8-oxoguanosine (oxo8Gua)] excreted into the spent culture medium after DNA repair or turnover. At growth inhibitory, but not cytolytic concentrations, asbestos caused significant elevation of all bases in the spent medium over a 48-h period. In contrast, riebeckite, a chemically similar, nonfibrous analog of crocidolite did not cause increased adduct release. Results show that oxidative RNA and DNA bases are produced in response to asbestos in target cells of asbestos-induced cancers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Comparison between the biological effects of asbestos and non-fibrous particles of similar chemical composition, such as crocidolite and riebeckite, has demonstrated a greater potency of the fibrous counterparts to produce apoptosis, oxidative DNA damage, DNA breakage and to induce proto-oncogene expression [88-93].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [88]
In the citing paper
“A number of in vitro and in vivo studies have suggested that shape, cristallinity, chemical composition and durability are important factors accounting for the biological activities of fibers, especially their carcinogenic potency.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [88]
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Self-citationAsbestos: Scientific Developments and Implications for Public Policy
Mossman, B. T., Bignon, J., Corn, M., Seaton, A., & Gee, J. B. L. (1990) · Science · doi:10.1126/science.2153315 · Cited by 742
Self-citationUrinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
Shigenaga, M. K., Gimeno, C. J., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9697 · Cited by 732
Self-citationOxidative DNA damage and senescence of human diploid fibroblast cells.
Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720
Self-citationShigenaga, M. K., Aboujaoude, E. N., Chen, Q., & Ames, B. N. (1994) · Methods in Enzymology · doi:10.1016/0076-6879(94)34073-0 · Cited by 298
Self-citationAsbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide
Weitzman, S. A., & Graceffa, P. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90078-x · Cited by 292
Mechanisms of Carcinogenesis and Clinical Features of Asbestos-Associated Cancers
Mossman, B. T., Kamp, D. W., & Weitzman, S. A. (1996) · Cancer Investigation · doi:10.3109/07357909609018904 · Cited by 194
Self-citationYang, K., Reddel, R. R., Gerwin, B. I., Reddel, H. K., Somers, A. N. A., McMenamin, M. G., LaVeck, M. A., Stahel, R. A., Lechner, J. F., & Harris, C. C. (1989) · PubMed Central · Cited by 140
DNA damage induced by asbestos in the presence of hydrogen peroxide.
Kasai, H., & Nishimura, S. (1984) · PubMed · Cited by 103
Cited by
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Reactive oxygen species in human health and disease
Castro, L., & Freeman, B. A. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00570-0 · Cited by 296
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Burmeister, B., Schwerdtle, T., Poser, I., Hoffmann, E., Hartwig, A., Müller, W.-U., Rettenmeier, A. W., Seemayer, N. H., & Dopp, E. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.11.003 · Cited by 52
Wu, J., Liu, W., Koenig, K., Idell, S., & Broaddus, V. C. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.5.l916 · Cited by 40
Metadata
- Authors
- Chen, Q., Marsh, J., Ames, B., & Mossman, B.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 17
- Issue
- 11
- Pages
- 2525-2527
- ISSN
- 0143-3334
- 1460-2180
- Cited by
- 33
- References
- 23
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. https://app.cochat.ai/papers/10.1093/carcin/17.11.2525
- The paper
- Chen, Q., Marsh, J., Ames, B., & Mossman, B. (1996). Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. Carcinogenesis. https://doi.org/10.1093/carcin/17.11.2525
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
