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Genome changes and gene expression in human solid tumors
Abstract
Genome-wide analysis techniques such as chromosome painting, comparative genomic hybridization, representational difference analysis, restriction landmark genome scanning and high-throughput analysis of LOH are now accelerating high-resolution genome aberration localization in human tumors. These techniques are complemented by procedures for detection of differentially expressed genes such as differential display, nucleic acid subtraction, serial analysis of gene expression and expression microarray analysis. These efforts are enabled by work from the human genome program in physical map development, cDNA library production/sequencing and in genome sequencing. This review covers several commonly used large-scale genome and gene expression analysis techniques, outlines genomic approaches to gene discovery and summarizes information that has come from large-scale analyses of human solid tumors.
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Cites
Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
Bunz, F., Hwang, P. M., Torrance, C., Waldman, T., Zhang, Y., Dillehay, L., Williams, J., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6863 · Cited by 1,044
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DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 951
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Rich, T., Allen, R. L., & Wyllie, A. H. (2000) · Nature · doi:10.1038/35037717 · Cited by 724
The genetics and genomics of cancer
Balmain, A., Gray, J., & Ponder, B. (2003) · Nature Genetics · doi:10.1038/ng1107 · Cited by 573
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Maser, R. S., & DePinho, R. A. (2002) · Science · doi:10.1126/science.297.5581.565 · Cited by 561
Cancer and ageing: rival demons?
Campisi, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1073 · Cited by 512
Metadata
- Authors
- Gray, J. W., & Collins, C.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 21
- Issue
- 3
- Pages
- 443-452
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2152365292
- Cited by
- 193
- References
- 1
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gray, J. W., & Collins, C. (2000). Genome changes and gene expression in human solid tumors. Carcinogenesis. https://doi.org/10.1093/carcin/21.3.443
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