The age of cancer
Abstract
A striking link exists between advanced age and increased incidence of cancer. Here I review how several of the age-related molecular and physiological changes might act in concert to promote cancer, and in particular epithelial carcinogenesis. Experimental data indicate that the aged, cancer-prone phenotype might represent the combined pathogenetic effects of mutation load, epigenetic regulation, telomere dysfunction and altered stromal milieu. Further verification of the role of these effects should in turn lead to the design of effective therapeutics for the treatment and prevention of cancer in the aged.
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Both processes would function to impede the accumulation of a greater number of somatic mutations thought to be required for the development of epithelial cancers.
“Both processes would function to impede the accumulation of a greater number of somatic mutations thought to be required for the development of epithelial cancers (50, 51).”
From <i>Ink4a</i> / <i>Arf</i> tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse (2007) · cites this paper as [51]
Age is a significant risk factor for the development of cancer.
“Age is a significant risk factor for the development of cancer.”
From Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis (2016) · cites this paper as [1]
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- Authors
- DePinho, R. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- DePinho, Ronald A.
- ORCID
- DePinho, Ronald A.
- Venue
- Nature
- Published
- 2000-11
- Volume
- 408
- Issue
- 6809
- Pages
- 248-254
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1552282019
- Cited by
- 951
- References
- 96
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 28 · 2023: 28 · 2022: 19 · 2021: 34 · 2020: 19 · 2019: 29 · 2018: 29 · 2017: 35 · 2016: 19 · 2015: 38 · 2014: 41 · 2013: 38 · 2012: 36
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- aging, cancer incidence, epithelial carcinogenesis, mutational burden, epigenetic regulation, telomere dysfunction, tumor microenvironment, cancer prevention
- MeSH terms
- Aging, Animals, Humans, Neoplasms, Incidence, Telomere, Genome, Mice
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