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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition
Abstract
Quercetin (30 mumol/mouse) markedly suppressed the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA, 20 nmol/mouse) on skin tumor formation in the CD-1 mice initiated by 7,12-dimethylbenz[a]anthracene (200 nmol/mouse). TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA. In addition, quercetin potently inhibited lipoxygenase from 105 000 g supernatant of epidermal homogenate of mice. The 50% inhibition of lipoxygenase was observed by quercetin at 1.3 microM. These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity.
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Hertog, M. G. L., Hollman, P. C. H., & Katan, M. B. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00024a011 · Cited by 1,378
The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
Yoshida, M., Sakai, T., Hosokawa, N., Marui, N., Matsumoto, K., Fujioka, A., Nishino, H., & Aoike, A. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80053-l · Cited by 317
Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells
TANIGAWA, S., FUJII, M., & HOU, D.-X. (2008) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.70680 · Cited by 135
Metadata
- Authors
- Kato, R., Nakadate, T., Yamamoto, S., & Sugimura, T.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1983
- Volume
- 4
- Issue
- 10
- Pages
- 1301-1305
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1986735216
- Cited by
- 214
- References
- 0
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. https://app.cochat.ai/papers/10.1093/carcin/4.10.1301
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- Kato, R., Nakadate, T., Yamamoto, S., & Sugimura, T. (1983). Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis. https://doi.org/10.1093/carcin/4.10.1301
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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