Modification of lung tumor growth by hyperoxia
Abstract
The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibition of tumor development by oxygen, although BHT retained its capability to enhance tumor development in mouse lung. In visible-size tumors, oxygen did not depress DNA synthesis. Oxygen also reduced the number of pulmonary metastatic nodules after i.v. injection of mammary gland-derived carcinoma cells, but failed to inhibit growth of murine lung carcinoma or murine melanoma-derived cell lines. Rats treated with one single intratracheal instillation of 3-methylcholanthrene developed multiple lung lesions; their growth could be prevented by exposure of the animals to 40 or 70% O2. It is concluded that hyperoxia prevents development of transformed cells in vivo in the lung and may affect adversely the growth of selected cell lines metastatic to the lung.
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Lindenschmidt et al. demonstrated that sustained exposure to 70% oxygen in mice inhibited the development of lung tumors.
“The application of early hyperoxia in tumor therapy is controversial, and Lindenschmidt et al. demonstrated that sustained exposure to 70% oxygen in mice inhibited the development of lung tumors.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [288]
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Self-citation
- Authors
- Lindenschmidt, R. C., Margaretten, N., Griesemer, R. A., & Witschi, H. P.
- Affiliations
- Oak Ridge National Laboratory (US)
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 7
- Issue
- 9
- Pages
- 1581-1586
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2040778912
- Cited by
- 22
- References
- 0
- Citations by year
- 2023: 1 · 2017: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carcinogenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-09336)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hyperoxia, lung cancer, tumor growth inhibition, oxygen, 3-methylcholanthrene, urethane, antioxidants, butylated hydroxytoluene, butylated hydroxyanisole, lung metastasis, mammary gland carcinoma, melanoma, DNA synthesis
- MeSH terms
- Animals, Butylated Hydroxyanisole, Butylated Hydroxytoluene, Cell Division, DNA, Dose-Response Relationship, Drug, Lung Neoplasms, Male, Methylcholanthrene, Mice, Inbred BALB C, Mice, Inbred C57BL, Oxygen, Rats, Inbred F344, Mice, Rats
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