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Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA
Abstract
Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.
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Citations
Cited by
Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., & Ames, B. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4533 · Cited by 1,106
Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
Shigenaga, M. K., Gimeno, C. J., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9697 · Cited by 732
Carcinogen-mediated oxidant formation and oxidative DNA damage
Frenkel, K. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90047-4 · Cited by 379
Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage
Shigenaga, M. K., & Ames, B. N. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90078-h · Cited by 364
Chronic oxidative stress and radiation‐induced late normal tissue injury: a review
Robbins, M. E. C., & Zhao, W. (2004) · International Journal of Radiation Biology · doi:10.1080/09553000410001692726 · Cited by 349
Metadata
- Authors
- Kasai, H., Nishimura, S., Kurokawa, Y., & Hayashi, Y.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 8
- Issue
- 12
- Pages
- 1959-1961
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W1982605253
- Cited by
- 344
- References
- 0
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. https://app.cochat.ai/papers/10.1093/carcin/8.12.1959
- The paper
- Kasai, H., Nishimura, S., Kurokawa, Y., & Hayashi, Y. (1987). Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis. https://doi.org/10.1093/carcin/8.12.1959
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
