Cited by 130Carcinogens and Genotoxicity AssessmentArsenic contamination and mitigationEpigenetics and DNA Methylation

Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells

Open access
Sciandrello, G.·2003·Carcinogenesis

Abstract

Early genetic instability induced in dividing V79-Cl3 Chinese hamster cells by inorganic arsenic, as demonstrated in our previous investigation, was evidenced by aneuploidy and nuclear abnormalities, but not by chromosomal rearrangements. Here we report the results of cytogenetic and morphological analyses performed on the progeny of cells dividing at the end of sodium arsenite treatment after they had been expanded through 120 generations (ASO cells) and then cloned. The acquired genetic instability persisted and was increased by highly unstable chromosomal rearrangements, namely dicentric chromosomes and telomeric associations, which were not seen following acute exposure. A peculiar finding was the preferential involvement of a particular chromosome in dicentric rearrangements observed in some isolated ASO clones. Interestingly, by immunostaining with anti-5-methylcytosine antibodies the genome-wide DNA hypomethylation, induced by arsenic immediately after the acute treatment, was found to affect those ASO clones characterized by aneuploidy and chromosomal rearrangements. These findings demonstrate that short-term exposure to arsenic has long-term effects and suggest that genome-wide DNA hypomethylation enhances genetic instability.

Integrity signals

Registry

Crossref · 10.1093/carcin/bgh029

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sciandrello, G.
Affiliations
University of Palermo (IT)
Corresponding author
Sciandrello, G.
Venue
Carcinogenesis
Published
2003-12-04
Volume
25
Issue
3
Pages
413-417
ISSN
  • 0143-3334 (ISSN-L)
  • 1460-2180
OpenAlex
W2116476764
Cited by
130
References
25
Citations by year
2026: 1 · 2025: 2 · 2023: 4 · 2022: 6 · 2021: 5 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 15 · 2013: 11 · 2012: 10
FWCI
1.12
Type
journal article
Language
en
Open access
Locations
  • Carcinogenesis (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
inorganic arsenic, sodium arsenite, DNA hypomethylation, chromosomal instability, genomic instability, dicentric chromosomes, chromosomal rearrangements, aneuploidy, telomeric associations, 5-methylcytosine, long-term exposure effects
MeSH terms
Animals, Antineoplastic Agents, Arsenic, Carcinogens, Chromosome Aberrations, Cricetinae, DNA Methylation, Cytogenetic Analysis, Chromosomal Instability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review