The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Apigenin inhibits tumor angiogenesis through decreasing HIF-1 and VEGF expression
Abstract
Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin in angiogenesis remains to be elucidated. Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis. In this study, we showed that apigenin-inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions. We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays. The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.
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Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Targeting HIF-1 for cancer therapy
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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Self-citationLoss of PTEN facilitates HIF-1-mediated gene expression
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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
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Cited by
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158
Flavonoids as prospective compounds for anti-cancer therapy
Ravishankar, D., Rajora, A. K., Greco, F., & Osborn, H. M. I. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.10.004 · Cited by 572
Lokman, N. A., Elder, A. S. F., Ricciardelli, C., & Oehler, M. K. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13089959 · Cited by 358
A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer
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Dietary chalcones with chemopreventive and chemotherapeutic potential
Orlikova, B., Tasdemir, D., Golais, F., Dicato, M., & Diederich, M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0210-5 · Cited by 273
Metadata
- Authors
- Fang, J., Zhou, Q., Liu, L.-Z., Xia, C., Hu, X., Shi, X., & Jiang, B.-H.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-09
- Volume
- 28
- Issue
- 4
- Pages
- 858-864
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2082384599
- Cited by
- 216
- References
- 10
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fang, J., Zhou, Q., Liu, L.-Z., Xia, C., Hu, X., Shi, X., & Jiang, B.-H. (2006). Apigenin inhibits tumor angiogenesis through decreasing HIF-1 and VEGF expression. Carcinogenesis. https://doi.org/10.1093/carcin/bgl205
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