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Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
Open accessAbstract
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965-2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07-1.60] and in the high (RR = 1.41; 95% CI = 1.16-1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34-3.68). The strongest association was found for stomach cancer [RR(medium) = 1.17 (95% CI = 0.37-3.70), RR(high) = 3.13 (95% CI = 1.17-8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.
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“More recently, we have developed an analogous database to simulate dicentric dose-response in human lymphocytes, which are considered among the best biomarkers of normal tissue damage risk [See, e.g. 2, 8, 18 -20].”
From Radiobiological damage by space radiation: extension of the BIANCA model to heavy ions up to iron, and pilot application to cosmic ray exposure (2022) · cites this paper as [19]
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Cites
Hapeman, D. E., & Agresti, A. (1991) · Technometrics · doi:10.1080/00401706.1991.10484817 · Cited by 9,407
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885 · cited 1×
“the approach suggested by Grambsch and Therneau ( 19 ) ( χ² (2df ) = 1.14; P=0.57).”
MethodInfluentialThe American Journal of Human Genetics
S., J. (1950) · Population · doi:10.2307/1523704 · Cited by 5,124
DNA double-strand breaks: signaling, repair and the cancer connection
Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics · doi:10.1038/85798 · Cited by 2,455
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400
Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3290 · Cited by 1,139
Suárez, E. L., Pérez, C. M., Nogueras, G. M., & Moreno-Gorrín, C. (2016) · CRC Press eBooks · doi:10.1201/b19547-8 · Cited by 1,049
Bonassi, S., Znaor, A., Ceppi, M., Lando, C., Chang, W. P., Holland, N., Kirsch‐Volders, M., Zeiger, E., Ban, S., Barale, R., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl177 · Cited by 1,024
Self-citationBonassi, S., Hagmar, L., Strömberg, U., Montagud, A. H., Tinnerberg, H., Forni, A., Heikkilä, P., Wanders, S., Wilhardt, P., Hansteen, I. L., et al. (2000) · PubMed · Cited by 493
Self-citationHagmar, L., Brögger, A., Hansteen, I. L., Heim, S., Högstedt, B., Knudsen, L. E., Lambert, B., Linnainmaa, K., Mitelman, F., & Nordenson, I. (1994) · PubMed · Cited by 485
Self-citationHagmar, L., Bonassi, S., Strömberg, U., Brögger, A., Knudsen, L. E., Norppa, H., & Reuterwall, C. (1998) · PubMed · Cited by 481
Self-citationClassification and relationships of induced chromosomal structual changes.
Savage, J. R. K. (1976) · Journal of Medical Genetics · doi:10.1136/jmg.13.2.103 · Cited by 461
Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer
Mitelman, F., Johansson, B., & Mertens, F. (2004) · Nature Genetics · doi:10.1038/ng1335 · Cited by 361
Canellos, G. P. (1976) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31845-4 · Cited by 343
Chromosome bands, their chromatin flavors, and their functional features.
Holmquist, G. P. (1992) · Europe PMC (PubMed Central) · Cited by 314
Chromosome Studies in Human Leukemia. II. Chronic Granulocytic Leukemia
Nowell̀, P. C., & Hungerford, D. A. (1961) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/27.5.1013 · Cited by 310
Multilevel Modelling of Health Statistics
Leyland, A. H., & Goldstein, H. (2001) · Cited by 307
Bonassi, S., Abbondandolo, A., Camurri, L., Prá, L. D., Ferrari, M. D., Degrassi, F., Forni, A., Lamberti, L., Lando, C., Padovani, P., et al. (1995) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(94)00131-t · Cited by 299
Self-citationRelationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer
Tsafrir, D., Bacolod, M. D., Selvanayagam, Z., Tsafrir, I., Shia, J., Zeng, Z., Liu, H., Krier, C., Stengel, R. F., Barany, F., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2569 · Cited by 279
Genetic pathways of two types of gastric cancer.
Tahara, E. (2004) · PubMed · Cited by 247
Impact of Types of Lymphocyte Chromosomal Aberrations on Human Cancer Risk
Hagmar, L., Strömberg, U., Bonassi, S., Hansteen, I., Knudsen, L. E., Lindholm, C., & Norppa, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3360 · Cited by 224
Self-citationChromosomal aberrations and risk of cancer in humans: an epidemiologic perspective
Bonassi, S., Znaor, A., Norppa, H., & Hagmar, L. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077519 · Cited by 200
Self-citationChromosomal Aberrations in Lymphocytes of Healthy Subjects and Risk of Cancer
Rössner, P., Boffetta, P., Ceppi, M., Bonassi, S., Šmerhovský, Z., Landa, K., Juzova, D., & Šrám, R. J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.6925 · Cited by 189
Self-citationChromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe
Boffetta, P., van der Hel, O., Norppa, H., Fabiánová, E., Fucic, A., Gundy, S., Lazutka, J. R., Cebulska-Wasilewska, A., Puskailerová, D., Znaor, A., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj367 · Cited by 183
Self-citationKimura, M., Umegaki, K., Higuchi, M., Thomas, P., & Fenech, M. F. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.48 · Cited by 170
Modelling Frequency and Count Data
Owen, W. L., & Lindsey, J. K. (1996) · Technometrics · doi:10.2307/1270619 · Cited by 118
An inter-nordic prospective study on cytogenetic endpoints and cancer risk
Brögger, A., Hagmar, L., Hansteen, I., Heim, S., Högstedt, B., Knudsen, L. E., Lambert, B., Linnainmaa, K., Mitelman, F., Nordenson, I., et al. (1990) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(90)90071-h · Cited by 89
Self-citationRisk of Cancer in an Occupationally Exposed Cohort with Increased Level of Chromosomal Aberrations
Šmerhovský, Z., Landa, K., Rössner, P., Brabec, M., Zudova, Z., Holá, N., Pokorna, Z., Mareckova, J., & Hurychova, D. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.0110941 · Cited by 85
Mechanisms of carcinogenesis : contributions of molecular epidemiology
Buffler, P. A. (2004) · International Agency for Research on Cancer eBooks · Cited by 47
Suárez, S., Sueiro, R. A., Araujo, M., Pardo, F., Menéndez, M., Pardiñas, M. C., & Álvarez, A. Á. (2006) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2006.09.012 · Cited by 12
Tinnerberg, H., Heikkilä, P., Montagud, A. H., Bernal, F., FORNI, A., Wanders, S., Welinder, H., Wilhardt, P., Strömberg, U., Norppa, H., et al. (2002) · The Annals of Occupational Hygiene · doi:10.1093/annhyg/mef094 · Cited by 8
Self-citation
Research works printed but not linked: 4
- Nowell, 1961, JNCI Journal of the National Cancer Institute, 27, 1013
- Hagmar, 1994, Cancer Research, 54, 2919
- Hagmar, 1998, Cancer Research, 58, 4117
- Bonassi, 2000, Cancer Research, 60, 1619
Cited by
Sorted by citations
Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles
Magdolénová, Z., Collins, A. R., Kumar, A., Dhawan, A., Stone, V., & Dušinská, M. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.773464 · Cited by 641
Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies
Bonassi, S., El‐Zein, R. A., Bolognesi, C., & Fenech, M. F. (2010) · Mutagenesis · doi:10.1093/mutage/geq075 · Cited by 477
Self-citationNon-targeted effects of ionising radiation—Implications for low dose risk
Kadhim, M. A., Salomaa, S. I., Wright, E. G., Hildebrandt, G., Belyakov, O. V., Prise, K. M., & Little, M. P. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.12.001 · Cited by 226
Assessing cancer risks of low-dose radiation
Mullenders, L. H. F., Atkinson, M., Paretzke, H. G., Sabatier, L., & Bouffler, S. D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2677 · Cited by 223
Ceppi, M., Biasotti, B., Fenech, M. F., & Bonassi, S. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.11.001 · Cited by 189
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Metadata
- Authors
- Bonassi, S., Norppa, H., Ceppi, M., Stromberg, U., Vermeulen, R., Znaor, A., Cebulska-Wasilewska, A., Fabianova, E., Fucic, A., Gundy, S., Hansteen, I.-L., Knudsen, L. E., Lazutka, J., Rossner, P., Sram, R. J., & Boffetta, P.
- Affiliations
- Finnish Institute of Occupational Health (FI)
- Utrecht University (NL)
- Hrvatski zavod za javno zdravstvo (HR)
- Institute of Nuclear Physics, Polish Academy of Sciences (PL)
- Public Health Authority of the Slovak Republic (SK)
- Institute for Medical Research and Occupational Health (HR)
- National Institute of Oncology (HU)
- Telemark Hospital (NO)
- University of Copenhagen (DK)
- Vilnius University (LT)
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Bonassi, S.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-04-15
- Volume
- 29
- Issue
- 6
- Pages
- 1178-1183
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- PMC
- PMC2443275
- OpenAlex
- W2106625186
- Cited by
- 336
- References
- 31
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 5 · 2023: 14 · 2022: 20 · 2021: 15 · 2020: 20 · 2019: 13 · 2018: 16 · 2017: 22 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 25 · 2012: 24
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Carcinogenesis (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Nordic Pharma Group
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- chromosomal abnormalities, peripheral blood lymphocytes, cancer risk prediction, ring chromosomes, chromosome-type aberrations, gastric cancer, carcinogen exposure, biomonitoring, cancer incidence, cancer mortality, pooled cohort analysis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Female, Humans, Lymphocytes, Male, Middle Aged, Neoplasms, Risk Factors, Cohort Studies, Incidence, Risk Assessment, Genetic Predisposition to Disease
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