The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
Abstract
Breast carcinogenesis is a multistep process involving both genetic and epigenetic changes. Since epigenetic changes like histone modifications are potentially reversible processes, much effort has been directed toward understanding this mechanism with the goal of finding novel therapies as well as more refined diagnostic and prognostic tools in breast cancer. Lysine-specific demethylase 1 (LSD1) plays a key role in the regulation of gene expression by removing the methyl groups from methylated lysine 4 of histone H3 and lysine 9 of histone H3. LSD1 is essential for mammalian development and involved in many biological processes. Considering recent evidence that LSD1 is involved in carcinogenesis, we investigated the role of LSD1 in breast cancer. Therefore, we developed an enzyme-linked immunosorbent assay to determine LSD1 protein levels in tissue specimens of breast cancer and measured very high LSD1 levels in estrogen receptor (ER)-negative tumors. Pharmacological LSD1 inhibition resulted in growth inhibition of breast cancer cells. Knockdown of LSD1 using small interfering RNA approach induced regulation of several proliferation-associated genes like p21, ERBB2 and CCNA2. Additionally, we found that LSD1 is recruited to the promoters of these genes. In summary, our data indicate that LSD1 may provide a predictive marker for aggressive biology and a novel attractive therapeutic target for treatment of ER-negative breast cancers.
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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p21 in cancer: Intricate networks and multiple activities
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Histone demethylation by a family of JmjC domain-containing proteins
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
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Self-citationReversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
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Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors
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Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487
The epigenetics of epithelial-mesenchymal plasticity in cancer
Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,163
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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
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Sprüssel, A., Schulte, J. H., Weber, S., Necke, M., Händschke, K., Thor, T., Pajtler, K. W., Schramm, A., König, K., Diehl, L., et al. (2012) · Leukemia · doi:10.1038/leu.2012.157 · Cited by 203
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Metadata
- Authors
- Lim, S., Janzer, A., Becker, A., Zimmer, A., Schüle, R., Buettner, R., & Kirfel, J.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-30
- Volume
- 31
- Issue
- 3
- Pages
- 512-520
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2137678309
- Cited by
- 470
- References
- 42
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. https://app.cochat.ai/papers/10.1093/carcin/bgp324
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- Lim, S., Janzer, A., Becker, A., Zimmer, A., Schüle, R., Buettner, R., & Kirfel, J. (2010). Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis. https://doi.org/10.1093/carcin/bgp324
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