Cited by 227Immunotoxicology and immune responsesEffects and risks of endocrine disrupting chemicalsImmune cells in cancer

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Environmental immune disruptors, inflammation and cancer risk

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Thompson, Patricia A., Khatami, Mahin, Baglole, Carolyn J., Sun, Jun, Harris, Shelley A., Moon, Eun-Yi, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Brown, Dustin G., Colacci, Anna Maria, Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A.Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Hamid, Roslida A., Lowe, Leroy, Guarnieri, Tiziana, Bisson, William H.·2015·Carcinogenesis

DOI 10.1093/carcin/bgv038PMC PMC4492068

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Abstract

An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is despite the well-recognized role that innate and adaptive immunity play as essential factors in tumorigenesis. Here, we review the role that the innate immune cells of inflammatory responses play in tumorigenesis. Focus is placed on the molecules and pathways that have been mechanistically linked with tumor-associated inflammation. Within the context of chemically induced disturbances in immune function as co-factors in carcinogenesis, the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed. Reported effects of bisphenol A, atrazine, phthalates and other common toxicants on molecular and cellular targets involved in tumor-associated inflammation (e.g. cyclooxygenase/prostaglandin E2, nuclear factor kappa B, nitric oxide synthesis, cytokines and chemokines) are presented as example chemically mediated target molecule perturbations relevant to cancer. Commentary on areas of additional research including the need for innovation and integration of systems biology approaches to the study of environmental exposures and cancer causation are presented.

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Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
Beatson, R., Tajadura‐Ortega, V., Achkova, D., Picco, G., Tsourouktsoglou, T.-D., Klausing, S., Hillier, M. C. J., Maher, J. F., Noll, T., Crocker, P. R., et al. (2016) · Nature Immunology · doi:10.1038/ni.3552 · Cited by 389
Towards targeting the breast cancer immune microenvironment
Harris, M. A., Savas, P. S., Virassamy, B., O’Malley, M. M. R., Kay, J., Mueller, S. N., Mackay, L. K., Salgado, R., & Loi, S. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00714-6 · Cited by 409
Volatile Organic Compounds in Air: Sources, Distribution, Exposure and Associated Illnesses in Children
Montero-Montoya, R. D., López‐Vargas, R., & Arellano‐Aguilar, O. (2018) · Annals of Global Health · doi:10.29024/aogh.910 · Cited by 364
CCL2/CCR2 signaling in cancer pathogenesis
Hao, Q., Vadgama, J. V., & Wang, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00589-8 · Cited by 324

See all 227

Authors: Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S. A., Moon, E.-Y., Al-Mulla, F., Al-Temaimi, R., Brown, D. G., Colacci, A. M., Mondello, C., Raju, J., Ryan, E. P., Woodrick, J., Scovassi, A. I., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L., Salem, H. K., Amedei, A., Hamid, R. A., Lowe, L., Guarnieri, T., & Bisson, W. H.
Affiliations: Sejong University (KR)
National Institutes of Health (US)
McGill University (CA)
Rush University (US)
Cancer Care Ontario (CA)
Kuwait University (KW)
Colorado School of Public Health (US)
Istituto di Genetica Molecolare (IT)
Health Canada (CA)
Georgetown University Medical Center (US)
King George's Medical University (IN)
Cairo University (EG)
University of Florence (IT)
Universiti Putra Malaysia (MY)
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Oregon State University (US)
ORCID: Thompson, Patricia A.
Khatami, Mahin
Baglole, Carolyn J.
Sun, Jun
Harris, Shelley A.
Moon, Eun-Yi
Al-Temaimi, Rabeah
Brown, Dustin G.
Mondello, Chiara
Raju, Jayadev
Ryan, Elizabeth P.
Scovassi, A.Ivana
Singh, Neetu
Vaccari, Monica
Roy, Rabindra
Forte, Stefano
Memeo, Lorenzo
Salem, Hosni K.
Amedei, Amedeo
Hamid, Roslida A.
Guarnieri, Tiziana
Bisson, William H.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2015-06
Volume: 36
Issue: Suppl 1
Pages: S232-S253
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/bgv038
PMC: PMC4492068
OpenAlex: W1959900099
Cited by: 227
References: 284
Citations by year: 2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 13 · 2021: 13 · 2020: 37 · 2019: 18 · 2018: 16 · 2017: 33 · 2016: 18 · 2015: 4
FWCI: 2.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Carcinogenesis (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
Florence Research (University of Florence) (submittedVersion)
eScholarship@McGill (McGill) (submittedVersion, cc-by)
Funders: National Cancer Institute (R01CA113447, R01CA092306, T32CA009686)
National Institute of Diabetes and Digestive and Kidney Diseases (K01DK075386, R03DK089010)
National Institute of Environmental Health Sciences (R13ES023276, P30ES000210)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: tumor inflammation, innate immunity, bisphenol A, atrazine, phthalates, NF-κB, nitric oxide production, cytokines and chemokines, chemical mixtures, systems biology
MeSH terms: Animals, Carcinogens, Environmental, Environmental Exposure, Humans, Immunity, Innate, Inflammation, Neoplasms, Risk, Carcinogenesis

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Environmental immune disruptors, inflammation and cancer risk

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