Bisson, William H.

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Sun, L., Xie, C., Wang, G., Wu, Y., Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., et al. (2018) · Nature Medicine

Gut microbiota and healthMetabolism, Diabetes, and Cancer

Cited by 1,011

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., et al. (2015) · Nature Communications

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 559

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D., & Perdew, G. H. (2015) · Scientific Reports

Gut microbiota and healthToxic Organic Pollutants Impact

Cited by 377

Environmental immune disruptors, inflammation and cancer risk

Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S. A., Moon, E.-Y., Al-Mulla, F., Al-Temaimi, R., Brown, D. G., Colacci, A. M., et al. (2015) · Carcinogenesis

Immunotoxicology and immune responsesEffects and risks of endocrine disrupting chemicals

Cited by 227

Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands

Bisson, W. H., Koch, D. C., O’Donnell, E. F., Khalil, S. M., Kerkvliet, N. I., Tanguay, R. L., Abagyan, R., & Kolluri, S. K. (2009) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsToxic Organic Pollutants Impact

Cited by 149

The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon Receptor

O'Donnell, E. F., Saili, K. S., Koch, D. C., Kopparapu, P. R., Farrer, D., Bisson, W. H., Mathew, L. K., Sengupta, S., Kerkvliet, N. I., Tanguay, R. L., et al. (2010) · PLoS ONE

Toxic Organic Pollutants ImpactImmunotoxicology and immune responses

Cited by 124

AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish

Goodale, B. C., La Du, J. K., Bisson, W. H., Janszen, D. B., Waters, K. M., & Tanguay, R. L. (2012) · PLoS ONE

Toxic Organic Pollutants ImpactZebrafish Biomedical Research Applications

Cited by 89

Suppression of Cytokine-Mediated Complement Factor Gene Expression through Selective Activation of the Ah Receptor with 3′,4′-Dimethoxy-α-naphthoflavone

Murray, I. A., Flaveny, C. A., Chiaro, C. R., Sharma, A. K., Tanos, R. S., Schroeder, J. C., Amin, S. G., Bisson, W. H., Kolluri, S. K., & Perdew, G. H. (2011) · Molecular Pharmacology

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 53

A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain

Perkins, A., Phillips, J., Kerkvliet, N., Tanguay, R., Perdew, G., Kolluri, S., & Bisson, W. (2014) · Biology

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 52