Developmental changes in brain metabolism in sedated rhesus macaques and vervet monkeys revealed by positron emission tomography
Abstract
The present positron emission tomography study used 2-deoxy-2[18F]fluoro-D-glucose to examine age-related changes in local cerebral metabolic rates for glucose (LCMRglc) in sedated rhesus macaques and vervet monkeys. Nineteen vervet monkeys were scanned in a cross-sectional design, which consisted of three age groups (birth to 59 d, 60-179 d, 180 d to adult) that captured the developmental period of greatest synaptic density within the second group. Two rhesus and two vervet monkeys were also examined longitudinally. Subjects were sedated throughout the procedure with a combination of ketamine and midazolam. Longitudinal and cross-sectional analyses of 20 brain regions indicated lowest LCMRglc in rhesus and vervet monkeys < 2 months of age (about 60% of adult levels). These metabolic rates more than doubled to approximately 155% of adult levels after the second postnatal month, coincident with transient synaptic overproduction and increased sociobehavioral activity. LCMRglc remained high until 6 months postnatally, coincident with continued dendritic growth and the emerging sociobehavioral independence of the young monkey. After 6 months, LCMRglc decreased gradually to adult levels. Thus, the period between 2 and 6 months is a time of peak metabolic activity, which coincides with increased histologic and behavioral activity in the developing monkey.
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Glucose utilization and synaptic density directly correlate, so FDG PET reflects synaptic integrity.
“Glucose utilization and synaptic density directly correlate, so to some extent FDG PET reflects synaptic integrity [194].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [194]
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Self-citation
- Authors
- Jacobs, B., Chugani, H. T., Allada, V., Chen, S., Phelps, M. E., Pollack, D. B., & Raleigh, M. J.
- Affiliations
- Colorado College (US)
- Wayne State University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Jacobs, B.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-05-01
- Volume
- 5
- Issue
- 3
- Pages
- 222-233
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2009064149
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 3 · 2013: 8 · 2012: 5
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2t32ca009092-26)
- National Cancer Institute (5T32-CA-09092-15)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain development, brain glucose metabolism, rhesus monkeys, vervet monkey, postnatal development, dendritic growth, 2-deoxy-2-[18F]fluoro-D-glucose, longitudinal neuroimaging
- MeSH terms
- Age Factors, Animals, Brain, Brain Mapping, Chlorocebus aethiops, Cerebral Cortex, Deoxyglucose, Glucose, Macaca mulatta, Male, Thalamus, Tomography, Emission-Computed, Age Distribution, Fluorodeoxyglucose F18
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