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Representing Spatial Information for Limb Movement: Role of Area 5 in the Monkey
Abstract
How is spatial information for limb movement encoded in the brain? Computational and psychophysical studies suggest that beginning hand position, via-points, and target are specified relative to the body to afford a comparison between the sensory (e.g., kinesthetic) reafferences and the commands that generate limb movement. Here we propose that the superior parietal lobule (Brodmann area 5) might represent a substrate for a body-centered positional code. Monkeys made arm movements in different parts of 3D space in a reaction-time task. We found that the activity of area 5 neurons can be related to either the starting point, or the final point, or combinations of the two. Neural activity is monotonically tuned in a body-centered frame of reference, whose coordinates define the azimuth, elevation, and distance of the hand. Each spatial coordinate tends to be encoded in a different subpopulation of neurons. This parcellation could be a neural correlate of the psychophysical observation that these spatial parameters are processed in parallel and largely independent of each other in man.
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“More specifically, the dorsal component of the SLF (SLF I) connects the dorsal and medial part of the frontal lobe (i.e., right middle frontal gyrus in Table 2) with the cingulate (Table 3) and cingulum (Table 5) of the superior and medial parietal cortex [56, 57].”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [56]
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Metadata
- Authors
- Lacquaniti, F., Guigon, E., Bianchi, L., Ferraina, S., & Caminiti, R.
- Affiliations
- University of Cagliari (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Lacquaniti, F.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 1995
- Volume
- 5
- Issue
- 5
- Pages
- 391-409
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2075717557
- Cited by
- 398
- References
- 0
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 18 · 2012: 10
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- superior parietal lobule, limb movement, arm reaching, hand position, altitude, distance, population coding, reaction time task
- MeSH terms
- Animals, Arm, Electrophysiology, Macaca nemestrina, Microelectrodes, Models, Neurological, Movement, Neurons, Orientation, Parietal Lobe, Reaction Time, Space Perception
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