The DOI matches its Crossref record; 95 of the 97 references it cites were found in a registry or an index.
Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents.
Open accessAbstract
Whole-brain diffusion tensor tractography (DTT) at high signal-to-noise ratio and angular and spatial resolutions were utilized to study the effects of age, sex differences, and lateral asymmetries of 6 white matter pathways (arcuate fasciculus [AF], inferior longitudinal fasciculus, inferior fronto-occipital fasciculus [IFOF], uncinate fasciculus [UF], corticospinal tract [CST], and somatosensory pathway [SS]) in 31 right-handed children (6-17 years). Fractional anisotropy (FA), a measure of the orientational variance in water molecular diffusivity, and the magnitude of water diffusivity (parallel, perpendicular, and mean diffusivity) along the pathways were quantified. Three major patterns of maturation were observed: 1) significant increase in FA with age, accompanied by significant decreases in all 3 diffusivities (e.g., left IFOF); 2) significant decreases in all three diffusivities with age without significant changes in FA (e.g., left CST); and 3) no significant age-related changes in FA or diffusivity (e.g., SS). Sex differences were minimal. Many pathways showed lateral asymmetries. In the right hemisphere, the frontotemporal (FT) segment of AF was not visualized in a substantial (29%) number of participants. FA was higher in the left hemisphere in the FT segment of AF, UF, and CST, whereas it was lower in the frontoparietal segment of AF. This study provides normative data essential for the interpretation of pediatric brain DTT measurements in both health and disease.
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“Age-related change in microstructure of white matter during childhood and adolescence is measurable using diffusion tensor imaging (DTI) (Lebel, Walker, Leemans, Phillips, & Beaulieu, 2008;Eluvathingal, Hasan, Kramer, Fletcher, & Ewing-Cobbs, 2007;Snook, Paulson, Roy, Phillips, & Beaulieu, 2005).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Eluvathingal et al., 2007
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Metadata
- Authors
- Eluvathingal, T. J., Hasan, K. M., Kramer, L., Fletcher, J. M., & Ewing-Cobbs, L.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- University of Houston (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-16
- Volume
- 17
- Issue
- 12
- Pages
- 2760-2768
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2084482
- OpenAlex
- W2166746511
- Cited by
- 288
- References
- 97
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 13 · 2019: 16 · 2018: 16 · 2017: 11 · 2016: 18 · 2015: 20 · 2014: 13 · 2013: 32 · 2012: 19
- FWCI
- 17.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS046308, R01NS052505)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035946, P01 HD 35946)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- diffusion tensor tractography, white matter maturation, association fibers, projection fibers, arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal tract, somatosensory pathways, fractional anisotropy, diffusion anisotropy, age-related changes, sex differences, lateral asymmetry, children and adolescents, reference values
- MeSH terms
- Adolescent, Adult, Aging, Brain, Child, Female, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Male, Nerve Fibers, Myelinated, Reference Values, Sex Factors, Diffusion Magnetic Resonance Imaging
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