Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways
Open accessAbstract
Here we define the expression of approximately 100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most gamma-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A regulatory network of Dlx1, Dlx2, Ascl1, Gsx1, and Gsx2 is required for specification of all GABAergic neurons in the subpallium.
“A regulatory network of genes encoding the transcription factors Dlx1, Dlx2, Ascl1, Gsx1 and Gsx2 is required for the specification of all GABAergic neurons in the subpallium”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Long et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 40 · Cited by 178
- Authors
- Long, J. E., Cobos, I., Potter, G. B., & Rubenstein, J. L. R.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-22
- Volume
- 19
- Issue
- suppl_1
- Pages
- i96-i106
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2693539
- OpenAlex
- W2160026138
- Cited by
- 178
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 14 · 2013: 16 · 2012: 14
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH4942801, F32MH070211, K05MH065670, R01MH049428, R37MH049428)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- DLX1, Dlx2, ASCL1, transcription factors, medial ganglionic eminence, caudal ganglionic eminence, basal ganglia, globus pallidus, basal telencephalon, GABAergic projection neurons, neuronal differentiation, transcriptional hierarchy, bHLH transcription factors, homeodomain genes, mouse brain development
- MeSH terms
- Animals, Brain, Cell Differentiation, Mice, Inbred C57BL, Transcription Factors, Signal Transduction, Homeodomain Proteins, Body Patterning, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
