The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Aging Effects on Whole-Brain Functional Connectivity in Adults Free of Cognitive and Psychiatric Disorders
Abstract
Aging is associated with decreased resting-state functional connectivity (RSFC) within the default mode network (DMN), but most functional imaging studies have restricted the analysis to specific brain regions or networks, a strategy not appropriate to describe system-wide changes. Moreover, few investigations have employed operational psychiatric interviewing procedures to select participants; this is an important limitation since mental disorders are prevalent and underdiagnosed and can be associated with RSFC abnormalities. In this study, resting-state fMRI was acquired from 59 adults free of cognitive and psychiatric disorders according to standardized criteria and based on extensive neuropsychological and clinical assessments. We tested for associations between age and whole-brain RSFC using Partial Least Squares, a multivariate technique. We found that normal aging is not only characterized by decreased RSFC within the DMN but also by ubiquitous increases in internetwork positive correlations and focal internetwork losses of anticorrelations (involving mainly connections between the DMN and the attentional networks). Our results reinforce the notion that the aging brain undergoes a dedifferentiation processes with loss of functional diversity. These findings advance the characterization of healthy aging effects on RSFC and highlight the importance of adopting a broad, system-wide perspective to analyze brain connectivity.
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Cites
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
The organization of the human cerebellum estimated by intrinsic functional connectivity
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The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
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“This is clearly relevant because cognitive and psychiatric disorders are highly prevalent in the general population (Ferri et al. 2005; Steel et al. 2014) and are associated with abnormalities in RSFC (Greicius 2008; Seeley et al. 2009).”
BackgroundThe adaptive brain: aging and neurocognitive scaffolding
Park, D. C., & Reuter-Lorenz, P. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093656 · Cited by 2,790
Emerging concepts for the dynamical organization of resting-state activity in the brain
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Self-citationResources for mental health: scarcity, inequity, and inefficiency
Saxena, S., Thornicroft, G., Knapp, M., & Whiteford, H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61239-2 · Cited by 1,789 · cited 2×
“…free of psychiatric disorders to minimize the confounding effects that these conditions have on RSFC. Scarcity of resources for mental health and stigma about mental disorders are widespread, and this restrains very significantly access to adequate diagnosis and treatment (Saxena et al. 2007).”
BackgroundDisruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592
Default Mode Network Activity and Connectivity in Psychopathology
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The cognitive neuroscience of ageing
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Reduced resting-state brain activity in the “default network” in normal aging
Damoiseaux, J. S., Beckmann, C. F., Arigita, E. J. S., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Rombouts, S. A. R. B. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm207 · Cited by 1,187 · cited 2×
“A number of previous fMRI investigations that focused on specific brain regions have found that age-related changes in functional connectivity remain significant after controlling for brain atrophy (Damoiseaux et al. 2008; Onoda et al. 2012; Langner et al. 2015).”
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Cited by
Cabral, J., Vidaurre, D., Marques, P., Magalhães, R., Silva Moreira, P., Miguel Soares, J., Deco, G., Sousa, N., & Kringelbach, M. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-05425-7 · Cited by 386
Segregated Systems of Human Brain Networks
Wig, G. S. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.09.006 · Cited by 357
Functional brain connectivity changes across the human life span: From fetal development to old age
Edde, M., Leroux, G., Altena, E., & Chanraud, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24669 · Cited by 143
Roestorf, A., Bowler, D. M., Deserno, M. K., Howlin, P., Klinger, L., McConachie, H., Parr, J. R., Powell, P., Van Heijst, B. F. C., & Geurts, H. M. (2019) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2018.08.007 · Cited by 87
Metadata
- Authors
- Ferreira, L. K., Regina, A. C. B., Kovacevic, N., Martin, M. D. G. M., Santos, P. P., Carneiro, C. D. G., Kerr, D. S., Amaro, E., McIntosh, A. R., & Busatto, G. F.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-08-26
- Volume
- 26
- Issue
- 9
- Pages
- 3851-3865
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2298073589
- Cited by
- 191
- References
- 19
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ferreira, L. K., Regina, A. C. B., Kovacevic, N., Martin, M. D. G. M., Santos, P. P., Carneiro, C. D. G., Kerr, D. S., Amaro, E., McIntosh, A. R., & Busatto, G. F. (2016). Aging Effects on Whole-Brain Functional Connectivity in Adults Free of Cognitive and Psychiatric Disorders. Cerebral Cortex. https://doi.org/10.1093/cercor/bhv190
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