The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study
Open accessAbstract
Background: Evidence is conflicting about how human immunodeficiency virus (HIV) modulates coronavirus disease 2019 (COVID-19). We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) World Health Organization (WHO) Clinical Characterization Protocol (CCP) study. Methods: We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, 10 individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy). Results: Among 47 592 patients, 122 (0.26%) had confirmed HIV infection, and 112/122 (91.8%) had a record of antiretroviral therapy. At presentation, HIV-positive people were younger (median 56 vs 74 years; P < .001) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. The cumulative day-28 mortality was similar in the HIV-positive versus HIV-negative groups (26.7% vs. 32.1%; P = .16), but in those under 60 years of age HIV-positive status was associated with increased mortality (21.3% vs. 9.6%; P < .001 [log-rank test]). Mortality was higher among people with HIV after adjusting for age (adjusted hazard ratio [aHR] 1.47, 95% confidence interval [CI] 1.01–2.14; P = .05), and the association persisted after adjusting for the other variables (aHR 1.69; 95% CI 1.15–2.48; P = .008) and when restricting the analysis to people aged <60 years (aHR 2.87; 95% CI 1.70–4.84; P < .001). Conclusions: HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19.
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“It is also noteworthy that mortality in the overall ISARIC CCP-UK population was higher than that reported in the New York study [21] and other countries [1].”
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Self-citationCOVID-19 in patients with HIV: clinical case series
Blanco, J. L., Ambrosioni, J., Garcia, F., Martínez, E., Soriano, A., Mallolas, J., & Miro, J. M. (2020) · The Lancet HIV · doi:10.1016/s2352-3018(20)30111-9 · Cited by 414
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Vizcarra, P., Pérez-Elías, M. J., Quereda, C., Moreno, A., Vivancos, M. J., Dronda, F., Casado, J. L., Moreno, S., Pérez-Elías, M. J., Fortún, J., et al. (2020) · The Lancet HIV · doi:10.1016/s2352-3018(20)30164-8 · Cited by 373
Cited by
Bhaskaran, K., Rentsch, C. T., MacKenna, B., Schultze, A., Mehrkar, A., Bates, C. J., Eggo, R. M., Morton, C. E., Bacon, S. C. J., Inglesby, P., et al. (2021) · The Lancet HIV · doi:10.1016/s2352-3018(20)30305-2 · Cited by 470
Ssentongo, P., Heilbrunn, E. S., Ssentongo, A. E., Advani, S., Chinchilli, V. M., Nunez, J. J., & Du, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-85359-3 · Cited by 325
Kent, S. J., Khoury, D. S., Reynaldi, A., Juno, J. A., Wheatley, A. K., Stadler, E., John Wherry, E., Triccas, J., Sasson, S. C., Cromer, D., et al. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00716-1 · Cited by 139
Nachega, J. B., Kapata, N., Sam-Agudu, N. A., Decloedt, E. H., Katoto, P. D. M. C., Nagu, T., Mwaba, P., Yeboah-Manu, D., Chanda-Kapata, P., Ntoumi, F., et al. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.03.038 · Cited by 80
Gates, M., Pillay, J., Wingert, A., Guitard, S., Rahman, S., Zakher, B., Gates, A., & Hartling, L. (2021) · doi:10.1101/2021.04.23.21256014 · Cited by 5
Metadata
- Authors
- Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., Villa, G., Docherty, A., Harrison, E. M., Turtle, L., Openshaw, P. J. M., Baillie, J. K., Sabin, C. A., & Semple, M. G.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-10-23
- Volume
- 73
- Issue
- 7
- Pages
- e2095-e2106
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W3048765898
- Cited by
- 283
- References
- 28
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Geretti, A. M., Stockdale, A. J., Kelly, S. H., Cevik, M., Collins, S., Waters, L., Villa, G., Docherty, A., Harrison, E. M., Turtle, L., Openshaw, P. J. M., Baillie, J. K., Sabin, C. A., & Semple, M. G. (2021). Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1605
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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