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Cited by 678

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection

Open access
Hung, Ivan FN, To, Kelvin KW, Lee, Cheuk-Kwong, Lee, Kar-Lung, Chan, Kenny, Yan, Wing-Wah, Liu, Raymond, Watt, Chi-Leung, Chan, Wai-Ming, Lai, Kang-Yiu, Koo, Chi-Kwan, Buckley, Tom, Chow, Fu-Loi, Wong, Kwan-Keung, Chan, Hok-Sum, Ching, Chi-Keung, Tang, Bone SF, Lau, Candy CY, Li, Iris WS, Liu, Shao-Haei, Chan, Kwok-Hung, Lin, Che-Kit, Yuen, Kwok-Yung·2011·Clinical Infectious Diseases
DOI 10.1093/cid/ciq106
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Abstract

Background. Experience from treating patients with Spanish influenza and influenza A(H5N1) suggested that convalescent plasma therapy might be beneficial. However, its efficacy in patients with severe pandemic influenza A(H1N1) 2009 virus (H1N1 2009) infection remained unknown. Methods. During the period from 1 September 2009 through 30 June 2010, we conducted a prospective cohort study by recruiting patients aged ≥18 years with severe H1N1 2009 infection requiring intensive care. Patients were offered treatment with convalescent plasma with a neutralizing antibody titer of ≥1:160, harvested by apheresis from patients recovering from H1N1 2009 infection. Clinical outcome was compared with that of patients who declined plasma treatment as the untreated controls. Results. Ninety-three patients with severe H1N1 2009 infection requiring intensive care were recruited. Twenty patients (21.5%) received plasma treatment. The treatment and control groups were matched by age, sex, and disease severity scores. Mortality in the treatment group was significantly lower than in the nontreatment group (20.0% vs 54.8%; P = .01). Multivariate analysis showed that plasma treatment reduced mortality (odds ratio [OR], .20; 95% confidence interval [CI], .06-.69; P = .011), whereas complication of acute renal failure was independently associated with death (OR, 3.79; 95% CI, 1.15-12.4; P = .028). Subgroup analysis of 44 patients with serial respiratory tract viral load and cytokine level demonstrated that plasma treatment was associated with significantly lower day 3, 5, and 7 viral load, compared with the control group (P < .05). The corresponding temporal levels of interleukin 6, interleukin 10, and tumor necrosis factor α (P < .05) were also lower in the treatment group. Conclusions. Treatment of severe H1N1 2009 infection with convalescent plasma reduced respiratory tract viral load, serum cytokine response, and mortality.

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Metadata

Authors
Hung, I. F., To, K. K., Lee, C.-K., Lee, K.-L., Chan, K., Yan, W.-W., Liu, R., Watt, C.-L., Chan, W.-M., Lai, K.-Y., Koo, C.-K., Buckley, T., Chow, F.-L., Wong, K.-K., Chan, H.-S., Ching, C.-K., Tang, B. S., Lau, C. C., Li, I. W., Liu, S.-H., Chan, K.-H., Lin, C.-K., & Yuen, K.-Y.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2011-02-15
Volume
52
Issue
4
Pages
447-456
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1093/cid/ciq106
OpenAlex
W2096238447
Cited by
678
References
30
FWCI
11.45
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection. https://app.cochat.ai/papers/10.1093/cid/ciq106
The paper
Hung, I. F., To, K. K., Lee, C.-K., Lee, K.-L., Chan, K., Yan, W.-W., Liu, R., Watt, C.-L., Chan, W.-M., Lai, K.-Y., Koo, C.-K., Buckley, T., Chow, F.-L., Wong, K.-K., Chan, H.-S., Ching, C.-K., Tang, B. S., Lau, C. C., Li, I. W., . . . Yuen, K.-Y. (2011). Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciq106

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.