The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The Diagnostic Value of Halo and Reversed Halo Signs for Invasive Mold Infections in Compromised Hosts
Open accessAbstract
The halo sign is a CT finding of ground-glass opacity surrounding a pulmonary nodule or mass. The reversed halo sign is a focal rounded area of ground-glass opacity surrounded by a crescent or complete ring of consolidation. In severely immunocompromised patients, these signs are highly suggestive of early infection by an angioinvasive fungus. The halo sign and reversed halo sign are most commonly associated with invasive pulmonary aspergillosis and pulmonary mucormycosis, respectively. Many other infections and noninfectious conditions, such as neoplastic and inflammatory processes, may also manifest with pulmonary nodules associated with either sign. Although nonspecific, both signs can be useful for preemptive initiation of antifungal therapy in the appropriate clinical setting. This review aims to evaluate the diagnostic value of the halo sign and reversed halo sign in immunocompromised hosts and describes the wide spectrum of diseases associated with them.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, in other studies the appearance of major lesions on high-resolution CT scans almost coincided with or even preceded the detection of the galactomannan antigen in serum (112).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [112]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917
Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Herbrecht, R., Denning, D. W., Patterson, T. F., Bennett, J. E., Greene, R. E., Oestmann, J.-W., Kern, W. V., Marr, K. A., Ribaud, P., Lortholary, O., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020191 · Cited by 3,304
Epidemiology and Outcome of Zygomycosis: A Review of 929 Reported Cases
Roden, M. M., Zaoutis, T. E., Buchanan, W. L., Knudsen, T. A., Sarkisova, T. A., Schaufele, R. L., Sein, M. T., Sein, T., Chiou, C. C., Chu, J. H., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/432579 · Cited by 3,094
Self-citationSmith‐Bindman, R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.427 · Cited by 2,467
Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315
Austin, J. H. M., Müller, N. L., Friedman, P. J., Hansell, D. M., Naidich, D. P., Rémy-Jardin, M., Webb, W. R., & Zerhouni, E. A. (1996) · Radiology · doi:10.1148/radiology.200.2.8685321 · Cited by 836
Cornely, O. A., Maertens, J. A., Bresnik, M., Ebrahimi, R., Ullmann, A. J., Bouza, E., Heußel, C. P., Lortholary, O., Rieger, C. T., Boehme, A., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/514341 · Cited by 744
Caillot, D., Casasnovas, O., Bernard, A., Couaillier, J. F., Durand, C. M., Cuisenier, B., Solary, É., Piard, F., Petrella, T., Bonnin, A., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.1.139 · Cited by 700
Imaging Findings in Acute Invasive Pulmonary Aspergillosis: Clinical Significance of the Halo Sign
Greene, R. E., Schlamm, H. T., Oestmann, J. W., Stark, P., Durand, C. M., Lortholary, O., Wingard, J. R., Herbrecht, R., Ribaud, P., Patterson, T. F., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/509917 · Cited by 589
Caillot, D., Couaillier, J.-F., Bernard, A., Casasnovas, O., Denning, D. W., Mannone, L., López, J. B., Couillault, G., Piard, F., Vagner, O., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.1.253 · Cited by 582
Research works printed but not linked: 7
- Parron, 2008, Archivos de bronconeumolog a, 44, 386
- Kami, 2000, Haematologica, 85, 745
- Bernard, 1995, Annales de chirurgie, 49, 849
- 1996, Acta Radiologica, 1996, 889
- Tzilas, 2010, European review for medical and pharmacological sciences, 14, 481
- Okubo, 2007, Nihon Koky ki Gakkai zasshi = the journal of the Japanese Respiratory Society, 45, 419
- Hata, 2005, Nihon Koky ki Gakkai zasshi = the journal of the Japanese Respiratory Society, 43, 23
Cited by
Sorted by citations
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw326 · Cited by 2,926
Self-citationAspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400
The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries
Hoenigl, M., Seidel, D., Carvalho, A., Rudramurthy, S. M., Arastehfar, A. A., Gangneux, J., Nasir, N., Bonifaz, A., Araiza, J., Klimko, N., et al. (2021) · The Lancet Microbe · doi:10.1016/s2666-5247(21)00237-8 · Cited by 539
The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries
Hoenigl, M., Seidel, D., Carvalho, A., Rudramurthy, S. M., Arastehfar, A. A., Gangneux, J., Nasir, N., Bonifáz, A., Araiza, J., Климко, Н. Н., et al. (2022) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 424
Millon, L., Herbrecht, R., Grenouillet, F., Morio, F., Alanio, A., Letscher‐Bru, V., Cassaing, S., Chouaki, T., Kauffmann‐Lacroix, C., Poirier, P., et al. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.12.006 · Cited by 259
Metadata
- Authors
- Georgiadou, S. P., Sipsas, N. V., Marom, E. M., & Kontoyiannis, D. P.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-04
- Volume
- 52
- Issue
- 9
- Pages
- 1144-1155
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC3106265
- OpenAlex
- W2170108937
- Cited by
- 292
- References
- 117
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 17 · 2020: 22 · 2019: 22 · 2018: 23 · 2017: 23 · 2016: 21 · 2015: 13 · 2014: 27 · 2013: 19 · 2012: 12
- FWCI
- 14.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 016672, P30CA016672)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Medical Imaging and Pathology Studies
- Keywords
- halo sign, reversed halo sign, invasive fungal infections, pulmonary aspergillosis, pulmonary mucormycosis, immunocompromised patients, pulmonary nodules, ground-glass opacities, computed tomography, antifungal therapy, diagnostic value
- MeSH terms
- Adult, Solitary Pulmonary Nodule, Humans, Infections, Lung, Lung Diseases, Fungal, Male, Mucormycosis, Neoplasms, Tomography, X-Ray Computed, Immunocompromised Host, Invasive Pulmonary Aspergillosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
